The CNS houses a number of glial and non-glial cell types that work cooperatively to counteract immune threats and maintain homeostasis. Innate immune responses in the CNS can be initiated locally through the function of these CNS resident cells. Sustained inflammation can lead to a hyperactive immune response, disruption of the blood-brain barrier (BBB), and recruitment of peripheral immune cells. Depending on the nature and duration of the neurotoxic insult, these events can dampen or amplify the inflammatory signals leading to cell death or resolution of inflammation.
Check out our additional webpages below for more information on each of these CNS-related cells: