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Novel Reagents for Apoptosis Detection

Revolutionize Apoptosis Detection with Apotracker™

 

Apotracker™ is a family of fluorogenic probes that detects externalized phosphatidylserine (PS) residues on apoptotic cells in a calcium-independent manner. Traditional apoptosis detection probes, such as Annexin V, require the presence of calcium, which can affect cell viability and marker expression. Apotracker exhibits a linear relationship with Annexin V staining and does not require a specialized buffer. It can also be useful for microscopy assays where it presents less background staining than traditional probes.

 

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Annexin V

 

Annexin V is a protein that binds to PS, and is commonly used as a probe to identify apoptotic cells. Annexin V binding occurs in a calcium-dependent manner, and its usage requires a binding buffer.

 

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Unstimulated (left) and Fas-stimulated (right) Jurkat cells stained with Annexin V-APC and Helix NP™ Green in Annexin V binding buffer.

Annexin A1

 

Annexin A1 (ANXA1) is another member of the annexin superfamily. ANXA1 has various functions, including inhibition of cytosolic phospholipase A2 (PLA2), regulation of inflammation, and induction of apoptosis. Annexin A1 is expressed on the cell surface during early apoptotic stages.

 

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Western blot with purified anti-Annexin A1 antibody (clone BL28553). Lane 1: Molecular weight marker; Lane 2: HeLa cell lysate; Lane 3: NIH3T3 cell lysate; Lane 4: human spleen lysate.

Antibody Detection of Cell Death and Survival

 

Looking for more ways to study cell death and survival? Explore our library of antibodies for detecting tumor suppressors like PTEN, or transcription factors like NF-κB.

 

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