LEGEND MAX™ Human IL-31 ELISA Kit with Pre-coated Plates

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Other Names
Interleukin-31, IL-31 Pre-coated ELISA Kit
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LEGENDMAX_Human_IL-31_ELISA
  • LEGENDMAX_Human_IL-31_ELISA
Description

Interleukin-31 (IL-31) is a newly identified member of the gp130/IL-6 cytokine family.It is composed of 144 amino acid and has molecular mass of 16 kD. IL-31 is produced mainly by type 2 T helper cells. The mature form of IL-31 contains a four helix structure. Human IL-31 shares 31% amino acid sequence identity with mouse IL-31.

IL-31 is a pleiotropic cytokine which is associated with immune response, hematopoiesis, and cytokine induction. IL-31 signals through a heterodimer receptor which consists of unique gp130-like receptor chain IL-31RA, and the receptor subunit OSMRβ that is shared with another family member oncostatin M (OSM). When IL-31 binds to the receptor, the complex is able to activate different signaling pathways including JAK/STAT, PI3K/AKT, and MAPK.

Studies on a mouse model show that high levels of IL-31 is associated with developing severe atopic dermatitis. IL-31 receptor expression is also increased in diseased tissues derived from an animal model of airway hypersensitivity. In addition, this cytokine plays a key role in the pathogenesis of inflammatory bowel disease.

The BioLegend LEGEND MAX™ Human IL-31 Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) kit includes a 96-well strip plate that is pre-coated with a goat polyclonal anti-human IL-31 capture antibody. The detection antibody is a biotinylated goat polyclonal anti-human IL-31 antibody. This kit is specifically designed for the accurate quantitation of human IL-31 from cell culture supernatant, serum, and plasma. It is analytically validated with ready-to-use reagents.

Product Details
Cat # Size Price Quantity Avail. Save
445707 1 Pre-coated Plate $395.00
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445708 5 Pre-coated Plates $1,395.00
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Technical data sheet

Kit Contents

Kit Contents
  • Anti-Human IL-31 Pre-coated 96-well Strip Microplate
  • Human IL-31 Dectection Antibody
  • Human IL-31 Standard
  • Avidin-HRP
  • Assay Buffer A
  • Wash Buffer (20X)
  • Substrate Solution F
  • Stop Solution
  • Plate Sealers

Antigen Details

Cell Sources
Helper T Cell
Materials Not Included
  • Microplate reader able to measure absorbance at 450 nm
  • Adjustable pipettes to measure volumes ranging from 1 µL to 1,000 µL
  • Deionized water
  • Wash bottle or automated microplate washer
  • Log-Log graph paper or software for data analysis
  • Tubes to prepare standard dilutions
  • Timer
  • Plate Shaker
  • Polypropylene vials
Sensitivity
1.1 pg/mL ± 0.4 pg/mL pg/mL
Standard Range
7.8-500 pg/mL
Gene ID
386653 View all products for this Gene ID
UniProt
View information about IL-31 on UniProt.org

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Go To Top Version: 0    Revision Date: 12/28/2016

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