Purified anti-mouse CD309 (VEGFR2, Flk-1) Antibody

Pricing & Availability
Clone
89B3A5 (See other available formats)
Other Names
Vascular endothelial growth factor receptor 2, VEGFR2, KDR, protein tyrosine kinase receptor flk-1, fetal liver kinase-1
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
89B3A5_Pure_021808
Mouse FLK-1 transfected cells stained with purified 89B3A5, followed by biotinylated anti-rat IgG and Sav-PE
  • 89B3A5_Pure_021808
    Mouse FLK-1 transfected cells stained with purified 89B3A5, followed by biotinylated anti-rat IgG and Sav-PE
Cat # Size Price Quantity Avail. Save
121902 100 µg $95
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Description

The 89B3A5 antibody recognizes mouse CD309 also known as vascular endothelial growth factor receptor 2, VEGFR2, KDR, protein tyrosine kinase receptor flk-1, and fetal liver kinase-1. Flk-1 is a member of the tyrosine protein kinase family, sub-family CSF-1/PDGF, that contains a single pass transmembrane receptor with a protein kinase domain and seven immunoglobulin-like domains in the extracellular region. Flk-1 is expressed at high levels in adult heart, lung, kidney, brain, and skeletal muscle; other tissues express at lower levels. Flk-1 is a receptor for VEGF or VEGFC; ligand binding plays a key role in vascular development and vascular permeability. The 89B3A5 antibody has been shown to be useful for flow cytometry.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Rat-1 cells transfected with full-length mouse Flk
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Kaburn N, et al. 1997. Development 124:2039.
Product Citations
  1. Dineen S, et al. 2008. Cancer Res. 68:4340. PubMed
RRID
AB_756162 (BioLegend Cat. No. 121902)

Antigen Details

Structure
Member of the tyrosine protein kinase family, sub-family CSF-1/PDGF. Single pass transmembrane receptor containing a protein kinase domain and seven immunoglobulin-like domains.
Distribution

Expressed at high levels in adult heart, lung, kidney, brain, and skeletal muscle; other tissues express at lower levels.

Function
Receptor for VEGF or VEGFC. Ligand binding plays a key role in vascular development and vascular permeability.
Ligand/Receptor
VEGF, VEGFC
Biology Area
Angiogenesis, Cell Biology, Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Patterson C, et al. 1995. J. Biol. Chem. 270:23111.
2. Quinn TP, et al. 1993. Proc. Natl. Acad. Sci. USA 90:7533.

Gene ID
16542 View all products for this Gene ID
UniProt
View information about CD309 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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