A synapse, where an axon terminal (presynapse) meets a dendrite (postsynapse), is the functional unit of the brain, and the site of connection between neurons or neuro-glial cells. Structural and functional alterations to the presynaptic terminals, and synapse loss are a common feature of many neurodegenerative disorders and are associated with sensory, motor, and cognitive impairments. In order to study synapses and how they are affected in disease, highly specific antibodies are needed that allow visualization of these structures, assessment of protein subcellular localization, protein co-localization, and expression within the pre- and postsynaptic compartments by microscopy or biochemical assays, namely western blotting (WB). Our Presynaptic Vesicle Antibody Sampler Kit contains antibodies for proteins involved in glutamate transport (VGlut1, SVOP), synaptic vesicle membrane fusion, and neurotransmitter release (Syntaxin, Synapsin, SNAP-25).
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