- Clone
- 5-369 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- ACE, kininase II, dipeptidyl dipeptidase 1, peptidase P, carboxycathepsin
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![5-369_PE_091509 5-369_PE_091509](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/5-369_PE_091509.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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GM-CSF-stimulated human monocytes (day-3) stained with the 5-369 PE (gated in CD14+ cell population)
CD143 (ACE, kininase II, peptidyl dipeptidase 1, peptidase P, carboxycathepsin) is a 171 kD, type I, single chain transmembranal metallopeptidase, whose cofactor is zinc. Its main targets are angiotensin I and bradykinin, acting as a blood pressure regulator. CD143 is expressed in endothelial cells; varying amounts of CD143 have been reported in different epithelial cells. The activation of macrophages and histiocytes induces the expression of this molecule.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
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AB_2222983 (BioLegend Cat. No. 344202)
Antigen Details
- Structure
- Single chain, type I transmembranal zinc metallopeptidase, 170 kD.
- Distribution
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Endothelial cells, some types of epithelial cells, activated macrophages and histiocytes.
- Function
- Regulates blood pressure by promoting vasoconstriction by the conversion of angiotensin I to angiotensin II and by the degradation of bradykinin, a vasodilator.
- Ligand/Receptor
- Angiotensin I, bradykinin.
- Bioactivity
- Blood pressure regulator.
- Cell Type
- Endothelial cells, Epithelial cells, Macrophages
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
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1. Nakamura T, et al. 2009. Int Heart J. 50:501.
2. Jayasooriya AP, et al. 2008. P. Natl. Acad. Sci. USA 105:6531.
3. Jokubaitis VJ, et al. 2008. Blood 111:4055.
4. Arndt PG, et al. 2006. J. Immunol. 177:7233.
5. Balyasnikova IV, et al. 2002. Biochem J. 362:585. - Gene ID
- 1636 View all products for this Gene ID
- UniProt
- View information about CD143 on UniProt.org
Related FAQs
Other Formats
View All CD143 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD143 (Angiotensin-converting enzyme) | 5-369 | FC |
PE anti-human CD143 (Angiotensin-converting enzyme) | 5-369 | FC |
APC anti-human CD143 (Angiotensin-converting enzyme) | 5-369 | FC |
PE/Cyanine7 anti-human CD143 (Angiotensin-converting enzyme) | 5-369 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD143 (Angiotensin-converting enzyme)
GM-CSF-stimulated human monocytes (day-3) stained with the 5... -
PE anti-human CD143 (Angiotensin-converting enzyme)
GM-CSF-stimulated human peripheral blood mononuclear cells (... -
APC anti-human CD143 (Angiotensin-converting enzyme)
GM-CSF-stimulated human peripheral blood mononuclear cells (... -
PE/Cyanine7 anti-human CD143 (Angiotensin-converting enzyme)
GM-CSF-stimulated human peripheral blood mononuclear cells (...
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