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PE/Cyanine7 anti-human CD56 (NCAM) Antibody

Pricing & Availability
Clone
HCD56 (See other available formats)
Regulatory Status
RUO
Other Names
Leu-19, NKH1
Isotype
Mouse IgG1, κ
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Product Citations
publications
HCD56_PECy7_070207
Human peripheral blood lymphocytes stained with HCD56 PE/Cyanine7
  • HCD56_PECy7_070207
    Human peripheral blood lymphocytes stained with HCD56 PE/Cyanine7
See PE/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
318317 25 tests 123€
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318318 100 tests 249€
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Description

CD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.

Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
Product Citations
  1. Liu Y, et al. 2017. Oncogene. 10.1038/onc.2017.209. PubMed
  2. Agelidis A, et al. 2017. Cell Rep. 10.1016/j.celrep.2017.06.041. PubMed
  3. Felices M, et al. 2018. JCI Insight. 3. PubMed
  4. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  5. Singh N, et al. 2017. J Endocrinol. 235:69. PubMed
  6. Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed
  7. Hakimi AA, et al. 2019. Cancer Discov. 9:510. PubMed
  8. Cooper GE, et al. 2018. Front Immunol. 9:1671. PubMed
  9. Kwant-Mitchell A, et al. 2009. PLoS One. 4:e8379. PubMed
  10. Gleason M, et al. 2012. Mol Cancer Ther. 11:2674. PubMed
  11. Romee R, et al. 2013. Blood. 121:3599. PubMed
  12. Wiernik A, et al. 2013. Clin Cancer Res. 19:3844. PubMed
  13. Cheent K, et al. 2013. Proc Natl Acad Sci U S A. 110:16981. PubMed
  14. Gleason M, et al. 2014. Blood. 123:3016. PubMed
  15. Terszowski G, et al. 2014. J Immunol. 192:5618. PubMed
  16. Madhavi V, et al. 2015. J Infect Dis. 211:529. PubMed
  17. Laroni A, et al. 2016. J Autoimmun. 72:8-18. PubMed
  18. Vallera D, et al. 2016. Clin Cancer Res. 22: 3440 - 3450. PubMed
  19. Mao Y, et al. 2016. Blood. 128: 1475 - 1489. PubMed
  20. Sadallah S, et al. 2016. J Immunol. 197: 1663 - 1671. PubMed
  21. Hansen A, et al. 2016. Sci Rep. 6:35406. PubMed
  22. Chen YP, et al. 2020. Cell Res. 30:1024. PubMed
  23. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  24. Nabet BY, et al. 2020. Cell. 183(2):363-376.e13. PubMed
  25. Parent AV, et al. 2021. Cell Reports. 36(7):109538. PubMed
  26. Van der Meer JM, et al. 2020. Cancer Immunol Immunother. . PubMed
  27. Calabrese DR, et al. 2020. J Clin Invest. . PubMed
  28. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  29. Wurzer H, et al. 2021. Front Immunol. 12:619069. PubMed
  30. Murdock BJ, et al. 2021. JCI Insight. 6:. PubMed
  31. Andreano E, et al. 2021. Nature. Online ahead of print. PubMed
  32. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  33. Arvindam US, et al. 2021. Leukemia. 35:1586. PubMed
  34. Pi J, et al. 2022. J Nanobiotechnology. 20:36. PubMed
  35. Izmirly AM, et al. 2022. PLoS Pathog. 18:e1009903. PubMed
  36. Figueroa-Romero C, et al. 2022. Front Immunol. 13:773288. PubMed
  37. Kim JT, et al. 2022. Nat Commun. 13:121. PubMed
  38. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  39. Zhao NQ, et al. 2020. PLoS One. 15:e0238347. PubMed
  40. Mishra HK, et al. 2021. Front Immunol. 12:711621. PubMed
  41. Zhang C, et al. 2021. Cancer Biol Med. :. PubMed
  42. Woods E, et al. 2021. NPJ Vaccines. 6:117. PubMed
  43. Wang H, et al. 2022. Front Immunol. 13:852436. PubMed
  44. Kucykowicz S, et al. 2022. STAR Protoc. 3:101356. PubMed
  45. Zhu S, et al. 2022. J Oncol. 2022:8724933. PubMed
  46. Fisher JG, et al. 2021. Front Oncol. 11:785635. PubMed
  47. Bernareggi D, et al. 2022. Nat Commun. 13:1899. PubMed
  48. Park SY, et al. 2022. NPJ Vaccines. 7:123. PubMed
  49. Wang S, et al. 2022. Cancer Immunol Immunother. Online ahead of print. PubMed
  50. Hagel J, et al. 2021. J Immunol. 206:3073. PubMed
  51. Andreano E, et al. 2023. Nat Commun. 14:53. PubMed
  52. Tunali G, et al. 2023. J Clin Invest. :. PubMed
RRID
AB_604099 (BioLegend Cat. No. 318317)
AB_604107 (BioLegend Cat. No. 318318)

Antigen Details

Structure
Ig superfamily, single transmembrane or GPI-anchored glycoprotein
Distribution

NK cells, T subset, neural tissue, some LGL and myeloid leukemias

Function
Adhesion
Ligand/Receptor
Heparin sulfate
Cell Type
B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Lanier L, et al. 1991. J. Immunol. 146:4421.
2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71.
3. Cremer H, et al. 1994. Nature 367:455.

Gene ID
4684 View all products for this Gene ID
UniProt
View information about CD56 on UniProt.org

Related FAQs

There are no FAQs for this product.

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Go To Top Version: 1    Revision Date: 11.30.2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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