Loading...

PerCP/Cyanine5.5 anti-mouse CD8a Antibody

Pricing & Availability
Clone
53-6.7 (See other available formats)
Regulatory Status
RUO
Other Names
T8, Lyt2, Ly-2
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
53-6dot7_PerCPCyanine55_CD8a_Antibody_102318
C57BL/6 mouse splenocytes were stained with CD3ε FITC and CD8a (clone 53-6.7) PerCP/Cyanine5.5, or Rat IgG2a, κ PerCP/Cyanine5.5 isotype control (bottom).
  • 53-6dot7_PerCPCyanine55_CD8a_Antibody_102318
    C57BL/6 mouse splenocytes were stained with CD3ε FITC and CD8a (clone 53-6.7) PerCP/Cyanine5.5, or Rat IgG2a, κ PerCP/Cyanine5.5 isotype control (bottom).
See PerCP/Cyanine5.5 spectral data
Cat # Size Price Quantity Check Availability Save
100733 25 µg 70€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
100734 100 µg 190€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse thymus or spleen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PerCP/Cyanine5.5 under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The CD8a antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is < 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone 53-6.7 antibody competes with clone 5H10-1 antibody for binding to thymocytes3. The 53-6.7 antibody has been reported to block antigen presentation via MHC class I and inhibit T cell responses to IL-2. This antibody has also been used for depletion of CD8a+ cells. Additional reported applications (for the relevant formats) include: immunoprecipitation1,3, in vivo and in vitro cell depletion2,10,15, inhibition of CD8 T cell proliferation3, blocking of cytotoxicity3,4, immunohistochemical staining5,6 of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, and spatial biology (IBEX)29,30. Clone 53-6.7 is not recommended for immunohistochemistry of formalin-fixed paraffin sections. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays or in vivo studies (Cat No. 100746).

Additional Product Notes

BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.

Application References

(PubMed link indicates BioLegend citation)
  1. Ledbetter JA, et al. 1979. Immunol. Rev. 47:63. (IHC, IP)
  2. Hathcock KS. 1991. Current Protocols in Immunology. 3.4.1. (Deplete)
  3. Takahashi K, et al. 1992. P. Natl. Acad. Sci. USA 89:5557. (Block, IP)
  4. Ledbetter JA, et al. 1981. J. Exp. Med. 153:1503. (Block)
  5. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  6. Fan WY, et al. 2001. Exp. Biol. Med. 226:1045. (IHC)
  7. Shih FF, et al. 2006. J. Immunol. 176:3438. (FC)
  8. Kamimura D, et al. 2006. J. Immunol. 177:306.
  9. Bouwer HGA, et al. 2006. P. Natl. Acad. Sci. USA 103:5102. (FC, Deplete)
  10. Kao C, et al. 2005. Int. Immunol. 17:1607. PubMed
  11. Ko SY, et al. 2005. J. Immunol. 175:3309. (FC) PubMed
  12. Rasmussen JW, et al. 2006. Infect. Immun. 74:6590. PubMed
  13. Lee CH, et al. 2009. Clin. Cancer Res. PubMed
  14. Geiben-Lynn R, et al. 2008. Blood 112:4585. (Deplete) PubMed
  15. Kingeter LM, et al. 2008. J. Immunol. 181:6244. PubMed
  16. Guo Y, et al. 2008. Blood 112:480. PubMed
  17. Andrews DM, et al. 2008. J. Virol. 82:4931. PubMed
  18. Britschqui MR, et al. 2008. J. Immunol. 181:7681. PubMed
  19. Kenna TJ, et al. 2008. Blood 111:2091. PubMed
  20. Jordan JM, et al. 2008. Infect. Immun. 76:3717. PubMed
  21. Todd DJ, et al. 2009. J. Exp. Med. 206:2151. PubMed
  22. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  23. Medyouf H, et al. 2010. Blood 115:1175. PubMed
  24. Riedl P, et al. 2009. J. Immunol. 183:370. PubMed
  25. Apte SH, et al. 2010. J. Immunol. 185:998. PubMed
  26. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  27. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  28. Cui L, et al. 2015. J Control Release. 206:220. PubMed
  29. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  30. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Borkner L, et al. 2017. J Immunol. 10.4049/jimmunol.1602115. PubMed
  2. Hönes J, et al. 2017. Sci Rep. . 10.1038/s41598-017-15866-9. PubMed
  3. Place D, et al. 2017. PLoS One. 10.1371/journal.pone.0190384. PubMed
  4. Chung L et al. 2018. Cell host & microbe. 23(2):203-214 . PubMed
  5. Solanki A, et al. 2018. Development. 145. PubMed
  6. Zhao N, et al. 2018. J Clin Invest. 26:84. PubMed
  7. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  8. Xu J et al. 2018. Cell. 173(3):762-775 . PubMed
  9. Lee SC et al. 2018. Cancer cell. 34(2):225-241 . PubMed
  10. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  11. White JP et al. 2018. Cell. 175(5):1198-1212 . PubMed
  12. Wang Z et al. 2018. Immunity. 49(1):80-92 . PubMed
  13. Kooreman NG et al. 2018. Cell stem cell. 22(4):501-513 . PubMed
  14. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  15. Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
  16. Shi R, et al. 2019. J Cancer. 10:367. PubMed
  17. Novince CM, et al. 2017. Sci Rep. 7:5747. PubMed
  18. Sultan H, et al. 2018. Cancer Immunol Res. 6:617. PubMed
  19. Niknam S, et al. 2018. Clin Cancer Res. 24:5735. PubMed
  20. Stivala S, et al. 2019. J Clin Invest. 130:1596. PubMed
  21. Karandikar SH, et al. 2019. Anal Chem. 91:3405. PubMed
  22. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  23. Barry KC, et al. 2018. Nat Med. 24:1178. PubMed
  24. Karandikar SH, et al. 2019. JCI Insight. 5. PubMed
  25. Contreras NA, et al. 2019. PLoS Pathog. 15:e1007890. PubMed
  26. Tan DQ, et al. 2019. Cell Rep. 26:2316. PubMed
  27. Bennion BG, et al. 2019. J Virol. 93. PubMed
  28. Schuster M, et al. 2017. J Immunol. 199:920. PubMed
  29. Schuster M, et al. 2019. Front Immunol. 10:1583. PubMed
  30. Highton AJ, et al. 2019. Wellcome Open Res. 4:78. PubMed
  31. Li A, et al. 2018. Cancer Lett. 431:54. PubMed
  32. Zhang P et al. 2019. Cell Rep. 27(11):3117-3123 . PubMed
  33. Zhang R, et al. 2019. Cell Rep. 28:2647. PubMed
  34. Kemp V, et al. 2018. Cancer Gene Ther. 26:268. PubMed
  35. Tang Y, et al. 2019. Nat Commun. 10:4157. PubMed
  36. Wu J et al. 2019. Immunity. 50(5):1218-1231 . PubMed
  37. Green DP, et al. 2019. Neuron. 101:412. PubMed
  38. Hendrikx S et al. 2019. Cell reports. 26(5):1227-1241 . PubMed
  39. Zhou J, et al. 2019. Immunity. 50:403. PubMed
  40. Chow MT et al. 2019. Immunity. 50(6):1498-1512 . PubMed
  41. Kim CJ, et al. 2018. Immunity. 49:1034. PubMed
  42. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  43. Yoon J et al. 2018. J Vis Exp. -141 . PubMed
  44. Ying Zhang et al. 2017. Cancer cell. 32(3):377-391 . PubMed
  45. Turecamo SE, et al. 2018. Matrix Biol. 67:01:00. PubMed
  46. Parks CA, et al. 2019. Proc Natl Acad Sci U S A. 116:3136. PubMed
  47. Mohammed RN, et al. 2019. Sci Rep. 4.185416667. PubMed
  48. Garber C, et al. 2019. Nat Neurosci. 1.802777778. PubMed
  49. Wang X, et al. 2019. Cell Res. 29:787. PubMed
  50. Wolf Y, et al. 2019. Cell. 179:219. PubMed
  51. Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
  52. Strattan E, et al. 2020. Frontiers in Immunology. 2.131944444. PubMed
  53. Field CS, et al. 2020. Cell Metab. 31:422. PubMed
  54. Eckert EC, et al. 2020. Mol Ther Oncolytics. 0.710416667. PubMed
  55. Zhang W, et al. 2020. Nat Commun. 11:1187. PubMed
  56. Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed
  57. Lang J, et al. 2020. Nat Commun. 11:1338. PubMed
  58. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  59. Ireland L, et al. 2020. Front Immunol. 11:297. PubMed
  60. Kunishita Y, et al. 2020. Front Immunol. 11:98. PubMed
  61. Terashima Y, et al. 2020. Nat Commun. 11:609. PubMed
  62. Ren J, et al. 2019. PLoS Biol. 17:e3000270. PubMed
  63. Aldon Y, et al. 2020. J Immunol. 204:903. PubMed
  64. Van Den Eeckhout B, et al. 2020. NPJ Vaccines. 0.252777778. PubMed
  65. Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
  66. Caetano MS, et al. 2019. Clin Cancer Res. 25:7576. PubMed
  67. Muri J, et al. 2020. Cell Reports. 29(9):2731-2744.e4.. PubMed
  68. Cohen MA, et al. 2020. Cell Stem Cell. 26(4):579-592. PubMed
  69. Hong JY, et al. 2020. Cell. 180(5):847-861. PubMed
  70. Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed
  71. Kienzl M, et al. 2020. Oncoimmunology. 9:1776059. PubMed
  72. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  73. Dekhtiarenko I, et al. 2013. J Immunol. 190:3399. PubMed
  74. Dutow P, et al. 2014. J Infect Dis. 209:1269. PubMed
  75. Hartwig S, et al. 2014. PLoS One. 9:90720. PubMed
  76. White C, et al. 2015. J Immunol. 194:697. PubMed
  77. Mizraji* G, et al. 2013. J Vis Exp. 77: 50388. PubMed
  78. MaruYama T, et al. 2015. J Leukoc Biol. 98: 385-393. PubMed
  79. RL M, et al. 2015. Proc Natl Acad Sci U S A. 112:6506-6514. PubMed
  80. Holvoet B, et al. 2015. Stem Cell Reports. 5: 1183-1195. PubMed
  81. JI B, et al. 2016. Cell Death Differ. 23:759-75. PubMed
  82. Pilzecker B, et al. 2016. Nucleic Acids Res. 44: 4734 - 4744. PubMed
  83. Uddback I, et al. 2016. Sci Rep. 6:20137. PubMed
  84. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  85. Xu Y, et al. 2016. Nat Commun. 7:12073. PubMed
  86. Gorman M, et al. 2016. J Virol. 90: 8212 - 8225. PubMed
  87. Collinson-Pautz M, et al. 2016. PLoS One. 11:e0164547. PubMed
  88. Chandra J, et al. 2016. Immunol Cell Biol. 10.1038/icb.2016.83. PubMed
  89. Dekhtiarenko I, et al. 2016. PLoS Pathog. 12:e1006072. PubMed
  90. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  91. Harvey RE et al. 2017. Endocrinology. 158(7):2179-2189 . PubMed
  92. Younes AI, et al. 2021. Transl Oncol. 14:100983. PubMed
  93. Parayath NN, et al. 2020. Nat Commun. 4.680555556. PubMed
  94. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  95. Barsoumian HB, et al. 2020. J Immunother Cancer. 8:00. PubMed
  96. Yin X, et al. 2020. Cell Rep. 33:108278. PubMed
  97. Chen L, et al. 2020. Cancer Immunol Res. 0.457638889. PubMed
  98. Dai L, et al. 2020. Cell. 182(3):722-733.e11. PubMed
  99. Cortez MA, et al. 2020. Nat Commun. 3.819444444. PubMed
  100. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  101. Cornax I, et al. 2021. Microorganisms. 9:00. PubMed
  102. Ruhland MK, et al. 2020. Cancer Cell. 37(6):786-799.e5. PubMed
  103. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  104. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  105. Gern BH, et al. 2021. Cell Host Microbe. 29(4):594-606.e6. PubMed
  106. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  107. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  108. Okada R, et al. 2021. EBioMedicine. 67:103345. PubMed
  109. Xing J, et al. 2021. Cell Reports. 35(12):109205. PubMed
  110. Sheppard S, et al. 2021. Cell Reports. 35(9):109210. PubMed
  111. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  112. Goc J, et al. 2021. Cell. 184:5015. PubMed
  113. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  114. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  115. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  116. Brigas HC, et al. 2021. Cell Reports. 36(9):109574. PubMed
  117. Guo X, et al. 2020. J Cell Mol Med. . PubMed
  118. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  119. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  120. Chen D, et al. 2020. Cancer Immunol Res. 8:883. PubMed
  121. Brooks JF, et al. 2020. Cytotherapy. 22:436. PubMed
  122. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  123. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  124. Yin Q, et al. 2021. Proc Natl Acad Sci U S A. 118: . PubMed
  125. Li E, et al. 2021. Front Immunol. 12:667177. PubMed
  126. Liu W, et al. 2021. Cell Death Discov. 7:136. PubMed
  127. Wang J, et al. 2021. Am J Cancer Res. 11:2005. PubMed
  128. Kim D, et al. 2021. Nanomicro Lett. 13:31. PubMed
  129. Zhao D, et al. 2020. Cancer Discov. 10:1374. PubMed
  130. Hu D, et al. 2021. J Cell Mol Med. 25:2900. PubMed
  131. Van Den Eeckhout B, et al. 2020. NPJ Vaccines. 5:64. PubMed
  132. Sugita J, et al. 2021. Nat Commun. 12:1910. PubMed
  133. Zhang H, et al. 2021. Front Immunol. 12:644520. PubMed
  134. Hildebrand KM, et al. 2021. PLoS One. 16:e0253864. PubMed
  135. Vella JL, et al. 2021. Life Sci Alliance. 4:. PubMed
  136. Carbone C, et al. 2021. J Immunother Cancer. 9:. PubMed
  137. Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
  138. Maulloo CD, et al. 2021. Front Immunol. 12:714842. PubMed
  139. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  140. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  141. Bourque J, et al. 2021. Heliyon. 7:e08311. PubMed
  142. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  143. Agrawal M, et al. 2021. Cells. 10:. PubMed
  144. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  145. Sun Y, et al. 2020. J Immunol. 205:2649. PubMed
  146. Mezzapelle R, et al. 2021. EMBO Mol Med. 13:e12344. PubMed
  147. Alameh MG, et al. 2021. Immunity. 54:2877. PubMed
  148. Hu Y, et al. 2021. J Nanobiotechnology. 19:416. PubMed
  149. Yu H, et al. 2021. Front Oncol. 11:736882. PubMed
  150. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  151. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  152. Yuan M, et al. 2022. Oxid Med Cell Longev. 2022:5479491. PubMed
  153. Zuo W, et al. 2022. Cell Death Discov. 8:257. PubMed
  154. Wang D, et al. 2022. EMBO Rep. 23:e53691. PubMed
  155. Chen YL, et al. 2022. Front Neurosci. 16:876582. PubMed
  156. Chen X, et al. 2021. Cell Rep. 37:109991. PubMed
  157. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  158. Sawada J, et al. 2021. Am J Pathol. 191:396. PubMed
  159. Murata A, et al. 2020. Front Immunol. 11:775. PubMed
  160. Unsinger J, et al. 2021. J Leukoc Biol. 109:697. PubMed
  161. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  162. Juul-Madsen K, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  163. Jing Y, et al. 2021. Front Immunol. 12:651860. PubMed
  164. Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed
  165. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  166. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  167. Brandi P, et al. 2022. Cell Rep. 38:110184. PubMed
  168. Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed
  169. Smith AS, et al. 2022. J Immunother Cancer. 10:. PubMed
  170. Ghorbani S, et al. 2022. Nat Commun. 13:2445. PubMed
  171. Sun Y, et al. 2022. Mol Ther Oncolytics. 25:160. PubMed
  172. Tondini E, et al. 2022. NPJ Vaccines. 7:64. PubMed
  173. Bullard BL, et al. 2022. NPJ Vaccines. 7:65. PubMed
  174. Ryan NM, et al. 2022. Front Immunol. 13:932742. PubMed
  175. Sun Y, et al. 2022. iScience. 25:104846. PubMed
  176. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  177. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  178. Zhang Z, et al. 2020. Nature. 579:415. PubMed
  179. Alotaibi F, et al. 2021. Front Immunol. 11:584937. PubMed
  180. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  181. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  182. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  183. Le QV, et al. 2022. Bioact Mater. 15:160. PubMed
  184. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  185. Hu Y, et al. 2022. J Nanobiotechnology. 20:417. PubMed
  186. Weaver JD, et al. 2022. Oncoimmunology. 11:2141007. PubMed
  187. Hodgson R, et al. 2022. Commun Biol. 5:1216. PubMed
  188. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  189. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  190. Nesseler JP, et al. 2020. Cancers (Basel). 12: . PubMed
  191. Behr FM, et al. 2021. Eur J Immunol. 51:151. PubMed
  192. Denny L, et al. 2021. Clin Transl Immunology. 10:e1234. PubMed
  193. Pohlmeier L, et al. 2021. Allergy. 76:2030. PubMed
  194. Stone ET, et al. 2022. Cell Rep. 38:110388. PubMed
  195. Goncharov NV, et al. 2022. J Evol Biochem Physiol. 58:230. PubMed
  196. Wemlinger SM, et al. 2022. J Immunol. 208:1566. PubMed
  197. Parga-Vidal L, et al. 2022. Eur J Immunol. 52:1095. PubMed
  198. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  199. Piñeros AR, et al. 2022. Cell Rep. 39:111011. PubMed
  200. Silva Pereira S, et al. 2022. Elife. 11: . PubMed
  201. Hong Y, et al. 2022. J Leukoc Biol. 112:425. PubMed
  202. Balood M, et al. 2022. Nature. 611:405. PubMed
  203. Ge Y, et al. 2022. iScience. 25:105437. PubMed
  204. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  205. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  206. Koutník J, et al. 2022. Front Immunol. 13:1049033. PubMed
  207. Briukhovetska D, et al. 2023. Immunity. 56:143. PubMed
  208. Arimoto KI, et al. 2023. Nat Commun. 14:251. PubMed
  209. Ai L, et al. 2023. Cell Discov. 9:9. PubMed
  210. Chen L, et al. 2023. Bioeng Transl Med. 8:e10377. PubMed
  211. Teymournejad O, et al. 2023. NPJ Vaccines. 8:3. PubMed
  212. Marritt KL, et al. 2023. Front Immunol. 13:1087991. PubMed
  213. Wang R, et al. 2023. iScience. 26:105954. PubMed
  214. Kemna J, et al. 2023. Nat Immunol. 24:414. PubMed
  215. Zhu X, et al. 2023. Front Immunol. 14:1114802. PubMed
  216. Gon Y, et al. 2023. PLoS One. 18:e0279389. PubMed
  217. Scherer S, et al. 2023. Nat Immunol. 24:501. PubMed
  218. Ferapontov A, et al. 2023. Nat Commun. 14:976. PubMed
  219. Shi X, et al. 2023. iScience. 26:106143. PubMed
  220. Pattnaik A, et al. 2023. Vaccines (Basel). 11:. PubMed
  221. Abdelwahab T, et al. 2023. iScience. 26:106698. PubMed
  222. Milighetti M, et al. 2023. iScience. 26:106937. PubMed
  223. Hu Y, et al. 2023. JCI Insight. 8:. PubMed
RRID
AB_2075239 (BioLegend Cat. No. 100733)
AB_2075238 (BioLegend Cat. No. 100734)

Antigen Details

Structure
Ig superfamily, CD8α chain, 34 kD
Distribution

Most thymocytes, T cell subset, some NK cells, lymphoid dendritic cells

Function
Co-receptor for TCR
Ligand/Receptor
MHC class I molecule
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Zamoyska R. 1994. Immunity 1:243.
3. Ellmeier W, et al. 1999. Annu. Rev. Immunol. 17:523.

Gene ID
12525 View all products for this Gene ID
UniProt
View information about CD8alpha on UniProt.org

Related FAQs

How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?

PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.

Go To Top Version: 3    Revision Date: 10.23.2018

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account