Purified anti-human CD300c Antibody

Pricing & Availability
Clone
TX45 (See other available formats)
Regulatory Status
RUO
Other Names
LIR, CLM-6, CMRF35, IGSF16, CMRF-35, CMRF35A, CMRF-35A, CMRF35A1, CMRF35-A1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
TX45_Pure_022309.jpg
Human peripheral blood monocytes stained with purified TX45, followed by anti-mouse IgG FITC
  • TX45_Pure_022309.jpg
    Human peripheral blood monocytes stained with purified TX45, followed by anti-mouse IgG FITC
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334802 100 µg 175€
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Description

CD300c, also known as CMRF-35-like molecule 6 (CLM-6) and leukocyte immunoglobulin-like receptor (LIR) is a 25 kD protein that belongs to the myeloid-associated immunoglobulin-like receptor (MAIR) family of genes. This transmembrane protein is expressed on certain B cells, T cells, NK cells, granulocytes, macrophages, monocytes, and mast cells. CD300C promotes secretion of proinflammatory cytokines and is an activating immune receptor associated ITAM-bearing adapter DAP12 and FcRγ chain on macrophages.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Simhadri VR, et al. 2013. J. Innate Immun. 4:389.
RRID
AB_2303773 (BioLegend Cat. No. 334802)

Antigen Details

Structure
Ig superfamily, 40 kD
Distribution

Monocytes/macrophages, dendritic cells

Function
Regulate myeloid cell activation and promote secretion of cytokines and chemokines
Interaction
DAP12, FcRγ
Cell Type
Dendritic cells, Macrophages, Monocytes
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Borrego F. 2013. Blood 11:1951.
2. Ju X, et al. 2009. Immunobiology 730-736.
3. Simhadri, et al. 2011. BMC Immunology 12:62.

Gene ID
10871 View all products for this Gene ID
UniProt
View information about CD300c on UniProt.org
Go To Top Version: 5    Revision Date: 08.31.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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