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PE anti-human CD105 Antibody

Pricing & Availability
Clone
43A3 (See other available formats)
Regulatory Status
RUO
Other Names
Endoglin
Isotype
Mouse IgG1, κ
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Product Citations
publications
43A3_PE_CD105_Antibody_FC_061715
Human mesenchymal stem cells were stained with CD105 (clone 43A3) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • 43A3_PE_CD105_Antibody_FC_061715
    Human mesenchymal stem cells were stained with CD105 (clone 43A3) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
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323205 25 tests 98€
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323206 100 tests 215€
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Description

CD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and β3 with high affinity but does not bind to TGF-β2.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
L-cells transfected with human CD105
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Bühring HJ, et al. 1991. Leukemia 5:841.
  2. Vogel W, et al. 2002. Haematologica 88:126.
  3. Osaka M, et al. 2011. Brain Res. 9:1343. PubMed
  4. HonMou O, et al. 2011. Brain. 134:1790. PubMed
  5. Herrera MB, et al. 2013. Hepatology. 57:311. PubMed
  6. Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed
Product Citations
  1. Wang G, et al. 2018. Int J Mol Med. 41:791. PubMed
  2. Kim SW, et al. 2018. Adv Sci (Weinh). 5:1700860. PubMed
  3. Ali S, et al. 2018. Purinergic Signal. 14:371. PubMed
  4. Sun W, et al. 2019. Exp Ther Med. 17:2199. PubMed
  5. Liu W, et al. 2018. Theranostics. 8:5575. PubMed
  6. He H, et al. 2019. J Cell Mol Med. 23:4139. PubMed
  7. Pan C, et al. 2019. Int J Mol Med. 44:1629. PubMed
  8. Nowak WN, et al. 2019. Mediators Inflamm. 2019:1868170. PubMed
  9. Lance R Thurlow et al. 2018. Journal of cellular biochemistry. 120(6):9213-9229 . PubMed
  10. Zhang Y, et al. 2019. Aging (Albany NY). 11:12641. PubMed
  11. Liu X, et al. 2020. Exp Ther Med. 1.258333333. PubMed
  12. Huang X, et al. 2019. Oxid Med Cell Longev. 2019:1305049. PubMed
  13. Mithal A, et al. 2020. Nat Commun. 0.607638889. PubMed
  14. Lee JK, et al. 2020. Sci Rep. 2.567361111. PubMed
  15. Hong Y, et al. 2020. Aging Cell. 19:e13128. PubMed
  16. Wu J, et al. 2020. Cell Res. 30:794. PubMed
  17. Honmou O, et al. 2011. Brain. 134:1790. PubMed
  18. Honmou O, et al. 2011. Brain. 1.307638889. PubMed
  19. Herrera M, et al. 2013. Hepatology. 57:311. PubMed
  20. Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed
  21. Panciera T, et al. 2016. Cell Stem Cell. 19:725-737. PubMed
  22. Schupp J, et al. 2021. Int J Mol Sci. 22:00. PubMed
  23. Melzer C, et al. 2020. Int J Mol Sci. :21. PubMed
  24. Khanh VC, et al. 2021. Stem Cells Dev. 30:758. PubMed
  25. Labedz-Maslowska A, et al. 2020. Int J Mol Sci. 21:. PubMed
  26. Shi L, et al. 2021. Stem Cell Res Ther. 12:147. PubMed
  27. Lee JK, et al. 2021. Cells. 10:. PubMed
  28. Park J, et al. 2021. Exp Ther Med. 22:808. PubMed
  29. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  30. Kokkinopoulos I, et al. 2021. Sci Rep. 11:15759. PubMed
  31. Sonoda S, et al. 2022. STAR Protoc. 3:101386. PubMed
  32. Liu Y, et al. 2022. iScience. 25:104405. PubMed
  33. Henson F, et al. 2021. J Orthop Res. 39:1411. PubMed
  34. Matheni C, et al. 2021. Cell J. 23:145. PubMed
  35. Zhang B, et al. 2022. Stem Cells Int. 2022:2236250. PubMed
  36. Xu L, et al. 2022. Int J Mol Sci. 23:. PubMed
  37. Liu C, et al. 2022. Regen Ther. 21:192. PubMed
  38. Wang W, et al. 2022. Int J Mol Sci. 23:. PubMed
  39. Zhang J, et al. 2022. Int J Mol Sci. 23:. PubMed
  40. Costa MHG, et al. 2021. Biotechnol J. 16:e2000389. PubMed
  41. Labedz-Maslowska A, et al. 2021. Cells. 10: . PubMed
  42. Polisetti N, et al. 2022. Bio Protoc. 12: . PubMed
  43. Robb KP, et al. 2022. Front Immunol. 13:972095. PubMed
  44. Zhu H, et al. 2022. Cell Transplant. 31:9636897221106996. PubMed
  45. Tamaoki N, et al. 2023. Cell Rep Methods. 3:100460. PubMed
RRID
AB_755957 (BioLegend Cat. No. 323205)
AB_755958 (BioLegend Cat. No. 323206)

Antigen Details

Structure
Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD
Distribution

Endothelial cells, activated monocytes/macrophages, bone marrow stromal cells, hematopoietic stem/progenitor cells

Function
Modulates cellular response to TGF-ß, involved in vascular development and remodelling
Ligand/Receptor
TGF-ß1, TGF-ß3
Cell Type
Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Mesenchymal Stem Cells, Monocytes
Biology Area
Angiogenesis, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Mason D, et al. Eds. 2002. Leucocyte Typing VII. Oxford University Press. New York.
2. Pierelli L, et al. 2001. Leuk. Lymphoma 42:1195.

Gene ID
2022 View all products for this Gene ID
UniProt
View information about CD105 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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