- Clone
- 4B10/HNRNPA1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![4B10-HNRNPA1_A488_HNRNPA1_Antibody_1_090919 4B10-HNRNPA1_A488_HNRNPA1_Antibody_1_090919](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/4B10-HNRNPA1_A488_HNRNPA1_Antibody_1_090919.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clone 4B10/HNRNPA1) on formalin-fixed paraffin-embedded mouse brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R, the tissue was incubated with 1 µg/ml of the primary antibody overnight at 4°C. The image was captured with a 40X objective. Scale bar: 50 µm -
IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clone 4B10/HNRNPA1) on formalin-fixed paraffin-embedded mouse brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R, the tissue was incubated with 1 µg/ml of the primary antibody overnight at 4°C. Nuclei were counterstained with DAPI. The image was captured with a 40X objective. Scale bar: 50 µm -
IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clone 4B10/HNRNPA1) on formalin-fixed paraffin-embedded rat brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R, the tissue was incubated with 1 µg/ml of the primary antibody overnight at 4°C. The image was captured with a 40X objective. Scale bar: 50 µm -
IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clone 4B10/HNRNPA1) on formalin-fixed paraffin-embedded rat brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/ml of the primary antibody overnight at 4°C. Nuclei were counterstained with DAPI. The image was captured with a 40X objective. Scale bar: 50 µm
Cat # | Size | Price | Quantity Check Availability | Save | ||
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862507 | 25 µg | £105 | ||||
862508 | 100 µg | £221 |
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multi-purpose RNA binding protein involved in RNA metabolism and DNA genomic stability in normal and pathological conditions. hnRNP A1 is ubiquitously expressed and usually associates with nascent RNA polymerase II transcripts. hnRNP A1 is abundantly expressed in neuronal cells and reproductive tissue. Loss of hnRNP A1 has been observed in several neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, amytrophic lateral sclerosis. Structurally, hnRNPA1 has two RNA recognition motifs, which are post-translationally modified to alter its nuclear pore shuttling properties and RNA interaction.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partially purified HeLa HNRNPA1 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
-
Blue Laser (488 nm)
- RRID
-
AB_2814597 (BioLegend Cat. No. 862507)
AB_2814598 (BioLegend Cat. No. 862508)
Antigen Details
- Structure
- hnRNPA1 has two isoforms. Human HNRPNA1 isoform A1-A is a 320 amino acid protein with a molecular mass of 34 kD, and isoform A1-B is a 372 amino acid protein with a molecular mass of 38 kD.
- Distribution
-
Tissue Distribution: Ubiquitous expression
Cellular Source: Nucleus and cytoplasm - Function
- RNA metabolism, genomic stability
- Interaction
- Nascent RNA polymerase II transcripts
- Cell Type
- Neurons
- Biology Area
- Neurodegeneration, Neuroscience, Protein Synthesis
- Antigen References
-
- Bekenstein U, et al. 2013. Mol Cell Neurosci. 56:436-46.
- Jean-Philippe J, et al. 2014. Biochim Biophys Acta. 1839(4): 251–258.
- Gene ID
- 3178 View all products for this Gene ID 15382 View all products for this Gene ID 29578 View all products for this Gene ID
- UniProt
- View information about HNRNPA1 on UniProt.org
Related FAQs
Other Formats
View All HNRNPA1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-HNRNPA1 | 4B10/HNRNPA1 | WB,IHC-P |
HRP anti-HNRNPA1 | 4B10/HNRNPA1 | WB,IHC-P |
Biotin anti-HNRNPA1 | 4B10/HNRNPA1 | IHC-P |
Alexa Fluor® 488 anti-HNRNPA1 | 4B10/HNRNPA1 | IHC-P |
Alexa Fluor® 594 anti-HNRNPA1 | 4B10/HNRNPA1 | IHC-P |
Alexa Fluor® 647 anti-HNRNPA1 | 4B10/HNRNPA1 | IHC-P |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-HNRNPA1
Western blot of purified anti-HNRNPA1 antibody (4B10/HNRNPA1... IHC staining of purified anti-HNRNPA1 antibody (clone 4B10/H... IHC staining of purified anti-HNRNPA1 antibody (clone 4B10/H... IHC staining of purified anti-HNRNPA1 antibody (clone 4B10/H... IIHC staining of purified anti-HNRNPA1 antibody (clone 4B10/... IHC staining of purified anti-HNRNPA1 antibody (clone 4B10/H... -
HRP anti-HNRNPA1
Western blot of HRP anti-HNRNPA1 antibody (clone 4B10/HNRNPA... IHC staining of HRP anti-HNRNPA1 antibody (clone 4B10/HNRNPA... IHC staining of HRP anti-HNRNPA1 antibody (clone 4B10/HNRNPA... -
Biotin anti-HNRNPA1
IHC staining of Biotin anti-HNRNPA1 antibody (clone 4B10/HNR... IHC staining of Biotin anti-HNRNPA1 antibody (clone 4B10/HNR... -
Alexa Fluor® 488 anti-HNRNPA1
IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clon... IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clon... IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clon... IHC staining of Alexa Fluor® 488 anti-HNRNPA1 antibody (clon... -
Alexa Fluor® 594 anti-HNRNPA1
IHC staining of Alexa Fluor® 594 anti-HNRNPA1 antibody (clon... IHC staining of Alexa Fluor® 594 anti-HNRNPA1 antibody (clon... -
Alexa Fluor® 647 anti-HNRNPA1
IHC staining of Alexa Fluor® 647 anti-HNRNPA1 antibody (clon... IHC staining of Alexa Fluor® 647 anti-HNRNPA1 antibody (clon... IHC staining of Alexa Fluor® 647 anti-HNRNPA1 antibody (clon... IHC staining of Alexa Fluor® 647 anti-HNRNPA1 antibody (clon...
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