- Clone
- AYP1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- C-type lectin domain family 1 member B, CLEC2B, PRO1384, QDED721
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![AYP1_APC_CLEC1B_Antibody_021317 AYP1_APC_CLEC1B_Antibody_021317](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/AYP1_APC_CLEC1B_Antibody_021317.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human platelets were stained with CLEC1B (clone AYP1) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
Cat # | Size | Price | Quantity Check Availability | Save | ||
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372005 | 25 tests | £106 | ||||
372006 | 100 tests | £240 |
C-type lectin domain family 1 member B (CLEC1B, CLEC2) is a 32kD, type II transmembrane protein, highly expressed on platelets and megakaryocytes. CLEC1B is involved in platelet activation and aggregation, and mediates the capture of HIV-1 by platelets. CLEC1B contains one hem-immunoreceptor tyrosine-based activation motif (hemITAM) though which interact with Syk and PLC-g. The known ligands of CLEC1B are rhodocytin and podoplanin.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular region of CLEC1B (amino acids 68-229).
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Red Laser (633 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: immunoprecipitation; inhibition of podoplanin and rhodocytin-mediated platelet activation.
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Application References
(PubMed link indicates BioLegend citation) -
- Gitz E, et al. 2014. Blood 124:2262.
- RRID
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AB_2650866 (BioLegend Cat. No. 372005)
AB_2650867 (BioLegend Cat. No. 372006)
Antigen Details
- Structure
- Type II transmembrane protein, 32 kD, homodimer, 1 hemITAM motif.
- Distribution
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Platelets, megakaryocytes; low expression on myeloid cells.
- Function
- Mediates platelet activation and aggregation; facilitates capture of HIV by platelets.
- Interaction
- Syk, PLC-g.
- Ligand/Receptor
- Rhodocytin, podoplanin.
- Cell Type
- Dendritic cells, Megakaryocytes, Platelets
- Biology Area
- Immunology
- Antigen References
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1. Manne BK, et al. 2015. J. Biol. Chem. 290:11557.
2. Hughes CE, et al. 2013. J. Biol. Chem. 288:5127.
3. Parguiña AF, et al. 2012. Blood 120:e117-26.
4. Osada M, et al. 2012. J. Biol. Chem. 287:22241. - Gene ID
- 51266 View all products for this Gene ID
- UniProt
- View information about CLEC1B on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CLEC1B (CLEC2) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CLEC1B (CLEC2) | AYP1 | FC,IP,Block |
APC anti-human CLEC1B (CLEC2) | AYP1 | FC |
PE anti-human CLEC1B (CLEC2) | AYP1 | FC |
FITC anti-human CLEC1B (CLEC2) | AYP1 | FC |
TotalSeq™-A0866 anti-human CLEC1B (CLEC2) | AYP1 | PG |
TotalSeq™-C0866 anti-human CLEC1B (CLEC2) | AYP1 | PG |
TotalSeq™-B0866 anti-human CLEC1B (CLEC2) | AYP1 | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CLEC1B (CLEC2)
Human platelets were stained with purified CLEC1B (clone AYP... -
APC anti-human CLEC1B (CLEC2)
Human platelets were stained with CLEC1B (clone AYP1) APC (f... -
PE anti-human CLEC1B (CLEC2)
Human platelets were stained with CLEC1B (clone AYP1) PE (fi... -
FITC anti-human CLEC1B (CLEC2)
Human platelets were stained with CLEC1B (clone AYP1) FITC (... -
TotalSeq™-A0866 anti-human CLEC1B (CLEC2)
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TotalSeq™-C0866 anti-human CLEC1B (CLEC2)
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TotalSeq™-B0866 anti-human CLEC1B (CLEC2)
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