- Clone
- TS1/8 (See other available formats)
- Regulatory Status
- RUO
- Workshop
- V S025
- Other Names
- LFA-2, T11, SRBC-R
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![TS1slash18_BV421_112311 TS1slash18_BV421_112311](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/TS1slash18_BV421_112311.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human peripheral blood lymphocytes stained with (clone TS1/8) Brilliant Violet 421™ (filled histogram) or mouse IgG1 Brilliant Violet 421™ isotype control (open histogram).
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
309217 | 25 tests | £133 | ||||
309218 | 100 tests | £268 |
CD2 is a 50 kD type I transmembrane glycoprotein also known as LFA-2, T11, and sheep red blood cell receptor (SRBC-R). This immunoglobulin superfamily member is expressed on thymocytes, T lymphocytes, NK cells, and thymic B cell subsets. The major ligand for CD2 is CD58 (also known as LFA-3). CD2 has also been reported to bind CD48, CD59, and CD15. CD2 plays a critical role in alternative T cell activation, T cell signaling, and cell-cell adhesion.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
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Violet Laser (405 nm)
- Application Notes
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Additional reported applications (for the relevant formats) include: blocking of T cell activation, and partial blocking of B cell costimulation2. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 309235 & 309236).
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Application References
(PubMed link indicates BioLegend citation) -
- Schlossman S, et al. Eds.1995. Leucocyte Typing V Oxford University Press. New York.
- Hughes CCW, et al. 1996. J. Biol. Chem. 271:5369.
- Product Citations
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- RRID
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AB_10915139 (BioLegend Cat. No. 309217)
AB_2561832 (BioLegend Cat. No. 309218)
Antigen Details
- Structure
- Ig superfamily, type I transmembrane glycoprotein, 50 kD
- Distribution
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T cells, NK cells, thymocytes, and thymic B cell subsets
- Function
- T cell activation, adhesion
- Ligand/Receptor
- CD58 (LFA-3), CD48, CD59, CD15
- Cell Type
- B cells, NK cells, T cells, Thymocytes
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
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1. Bell G, et al. 1995. J. Immunol. 155:2805.
2. Bierer B, et al. 1989. Annu. Rev. Immunol. 7:579.
3. Moingeon P, et al. 1989. Immunol. Rev. 111:111. - Gene ID
- 914 View all products for this Gene ID
- UniProt
- View information about CD2 on UniProt.org
Related FAQs
- What is the F/P ratio range of our BV421™ format antibody reagents?
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It is lot-specific. On average it ranges between 2-4.
Other Formats
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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FITC anti-human CD2
Human peripheral blood lymphocytes stained with TS1/8 FITC -
PE anti-human CD2
Whole blood lymphocytes stained with TS1/8 PE -
Purified anti-human CD2
Human peripheral blood lymphocytes stained with purified TS1... -
Pacific Blue™ anti-human CD2
Human peripheral blood lymphocytes stained with TS1/8 Pacifi... -
PE/Cyanine7 anti-human CD2
Human peripheral blood lymphocytes stained with TS1/8 PE/Cya... -
Brilliant Violet 421™ anti-human CD2
Human peripheral blood lymphocytes stained with (clone TS1/8... -
Purified anti-human CD2 (Maxpar® Ready)
Human PBMCs stained with 151Eu anti-CD2 (TS1/8) and 170Er an... -
PerCP/Cyanine5.5 anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
APC anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
APC/Fire™ 750 anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
Alexa Fluor® 700 anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
TotalSeq™-A0367 anti-human CD2
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TotalSeq™-C0367 anti-human CD2
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FITC anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
TotalSeq™-B0367 anti-human CD2
-
Ultra-LEAF™ Purified anti-human CD2
Human peripheral blood lymphocytes stained with Ultra-LEAF™ ... -
APC/Cyanine7 anti-human CD2
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
TotalSeq™-D0367 anti-human CD2
-
PE/Cyanine7 anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
PerCP/Cyanine5.5 anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
GMP PE anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
APC anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
APC/Fire™ 750 anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
Pacific Blue™ anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
GMP FITC anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
GMP APC/Fire™ 750 anti-human CD2
Typical results from human peripheral blood lymphocytes stai...
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