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- Clone
- 6B11 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TCR Vα24-Jα18, TCR Vα24-JαQ, invariant NKT cell, iNKT
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes stained with 6B11 APC (lower panel) or APC mouse IgG1 isotype control (upper panel) and CD3 (UCHT1) PE -
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 342907 | 25 tests | £102 | ||||
| 342908 | 100 tests | £240 | ||||
Encoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
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Red Laser (633 nm)
- Application Notes
-
The 6B11 antibody recognizes the invariant CDR3 region of TCR Va24-JaQ.
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Application References
(PubMed link indicates BioLegend citation) -
- Rout N, et al. 2010. PLoS One 5:e9787. (FC)
- Product Citations
- RRID
-
AB_1731920 (BioLegend Cat. No. 342907)
AB_1731848 (BioLegend Cat. No. 342908)
Antigen Details
- Structure
- Invariant CDR3 region of TCR Vα24-JαQ
- Distribution
-
Invariant NKT cells
- Ligand/Receptor
- Glycolipid loaded CD1d
- Cell Type
- NKT cells
- Biology Area
- Immunology
- Molecular Family
- TCRs
- Antigen References
-
- Thomas SY, et al. 2003. J. Immunol. 171:2571.
- Exley MA, et al. 2008. Eur. J. Immunol. 38:1756.
- Montoya CJ, et al. 2007. Immunology. 122:1.
- Gansuvd B, et al. 2003. J. Immunol. 171:2904.
- Gene ID
- 28659 View all products for this Gene ID
- UniProt
- View information about TCR Valpha24-Jalpha18 on UniProt.org
Related FAQs
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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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