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- Clone
- 2A2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Receptor tyrosine kinase-like orphan receptor 1, Tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase receptor-related 1, NTRKR1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human teratocarcinoma cell line NCCIT was stained with ROR1 (clone 2A2) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 357803 | 25 tests | £105 | ||||
| 357804 | 100 tests | £247 | ||||
ROR1, also known as NTRKR1, is a type I transmembrane protein and member of the ROR subfamily of surface receptors. ROR1 consists of one frizzled domain, one Ig-like C2-type domain, one kringle domain, and one kinase domain with no catalytic activity. ROR1 is expressed on embryonic tissue, in the central nervous system and on some cancer cells, and is used as a marker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand for ROR1.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Clone 2A2 binds to the membrane distal Ig-domain of ROR1. Clone 2A2 has also been shown to exhibit cross reactivity towards mouse ROR12.
-
Application References
(PubMed link indicates BioLegend citation) -
- Dave H, et al. 2012. PLoS One 7:e52655. (FC)
- Baskar S, et al. 2012. MAbs. 4:349. (FC)
- Product Citations
- RRID
-
AB_2561988 (BioLegend Cat. No. 357803)
AB_2561989 (BioLegend Cat. No. 357804)
Antigen Details
- Structure
- Type I transmembrane protein, consist of 1 frizzled domain, 1 Ig-like C2-type domain, 1 kringle domain, and 1 non-functional kinase domain; member of the ROR subfamily of surface receptors
- Distribution
-
Embryonic tissue, central nervous system, chronic lymphocytic leukemia cells
- Ligand/Receptor
- Wnt5a
- Cell Type
- Embryonic Stem Cells, Leukemia
- Biology Area
- Immunology, Stem Cells
- Antigen References
-
- Bicocca VT, et al. 2012. Cancer Cell. 22:656.
- Zhang S, et al. 2012. PLoS One 7:e31127.
- Uhrmacher S, et al. 2011. Leuk Res. 35:1360.
- Yang J, et al. 2011. PLoS One 6:e21018.
- Grumolato L, et al. 2010. Genes Dev. 24:2517.
- Gene ID
- 4919 View all products for this Gene ID
- UniProt
- View information about ROR1 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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