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Purified anti-human CD161 Antibody

Pricing & Availability
Clone
HP-3G10 (See other available formats)
Regulatory Status
RUO
Other Names
NKR-P1A
Isotype
Mouse IgG1, κ
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Product Citations
publications
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339902 100 µg £87
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Description

CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human,Cynomolgus,Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human NK cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
WB - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: inhibition of cytokine production and Western blotting under nonreducing conditions.

Application References

(PubMed link indicates BioLegend citation)
  1. Gumß M, et al. 2004. Blood 104:3664.
  2. Exley M, et al. 1998. J. Exp. Med. 188:867.
  3. Marquez C, et al. 1998. Blood 91:2760.
Product Citations
  1. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
  2. Volchenkov R, et al. 2017. Front Immunol. 0.818055556. PubMed
  3. Cardoso V, et al. 2017. Nature. 549:277. PubMed
  4. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  5. Ardain A, et al. 2019. Nature. 570:528. PubMed
  6. Chng MHY, et al. 2020. Immunity. 51(6):1119-1135.e5.. PubMed
  7. Gruber CN, et al. 2020. Cell. 183:982. PubMed
  8. Mathewson ND, et al. 2021. Cell. 184(5):1281-1298.e26. PubMed
  9. Schwabenland M, et al. 2021. Immunity. . PubMed
  10. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  11. Martin E, et al. 2020. JCI Insight. :5. PubMed
  12. Rouers A, et al. 2021. Cell Rep Med. 2:100278. PubMed
  13. Niu C, et al. 2021. Front Immunol. 12:658562. PubMed
  14. NULL, et al. 2022. Cell. 185:916. PubMed
  15. Marrero I, et al. 2020. Alcohol Clin Exp Res. 44:1061. PubMed
  16. Sattler A, et al. 2021. Am J Transplant. 21:87. PubMed
  17. Feyaerts D, et al. 2022. Cell Rep Med. 3:100680. PubMed
  18. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
RRID
AB_1501090 (BioLegend Cat. No. 339902)

Antigen Details

Structure
Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily
Distribution

NK cells, T subset, subset of CD3+ thymocytes

Ligand/Receptor
LLT-1 (Lectin-like transcript-1)
Cell Type
NK cells, T cells, Thymocytes
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Takahashi T, et al. 2006. J. Immunol. 176:211.
2. Cosmi L, et al. 2008. J. Exp. Med. 205:1903.
3. Aldemir H, et al. 2005. J. Immunol. 175:7791.
4. Rosen DB, et al. 2008. J. Immunol. 180:6508.

Gene ID
3820 View all products for this Gene ID
UniProt
View information about CD161 on UniProt.org

Related FAQs

There are no FAQs for this product.
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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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