Purified anti-Tubulin β 3 (TUBB3) Antibody (Previously Covance catalog# MMS-435P)

Pricing & Availability
Clone
TUJ1 (See other available formats)
Regulatory Status
RUO
Other Names
CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, Tubulin beta-3 chain, tubulin beta-III, tubulin beta-4 chain, class III beta-tubulin
Previously
Covance Catalog# MMS-435P
Isotype
Mouse IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • B_TUJ1_PURE_Tubulin-beta3_IHCP_Rat_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded rat brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • C_TUJ1_PURE_Tubulin-beta3_WB_011618
    Western blot of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of Mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blots were incubated with 1 ug/mL of TUJ1 or mouse IgG overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • D_TUJ1_PURE_Tubulin-beta3_ICC_011618
    ICC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on SH-SY5Y neuroblastoma cells. The cells were fixed by 4% PFA, permeabilized with a buffer containing 0.1% Triton X-100 and 0.25% BSA, and blocked with 2% Normal Goat Serum and 0.02% BSA. The cells were then incubated with 1 µg/mL of the primary antibody for 3 hours at room temperature, followed by incubation with 0.5 µg/mL Alexa Fluor® 594 goat anti-mouse IgG (Cat. No. 405326) for 1 hour at room temperature. Nuclei were counterstained with DAPI. The image was captured with a 60X objective Scale bar: 20 µm
  • E_Ankita_Patil
    Methanol fixed superior cervical ganglion neurons were stained with anti-tubulin β3 (pink) and anti-TRIM46 (aqua), then stained with secondary antibodies, phalloidin (orange) and DAPI (blue). Image generously submitted to the 2017 Cell Life Imaging Competition by Ankita Patil from Drexel University.
Compare all formats
Cat # Size Price Quantity Check Availability Save
801213 25 µL £73
Check Availability


Need larger quantities of this item?
Request Bulk Quote
801201 100 µL £182
Check Availability


Need larger quantities of this item?
Request Bulk Quote
801202 250 µL £268
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was raised against microtubules derived from rat brain.
Formulation
Phosphate-buffered solution + 0.03% Thimerosal.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1.0 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

IHC-P - Quality tested
WB, ICC - Verified
FC - Reported in the literature, not verified in house
SB - Community verified

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: flow cytometry4, immunofluorescence microscopy1-5,7, immunohistochemistry5,7, Western blotting8, and spatial biology (IBEX)9,10.

This antibody is well characterized and highly reactive to neuron specific Class III ß-tubulin (ßIII). TUJ1 does not identify ß-tubulin found in glial cells. TUJ1 recognizes an epitope located within the last 15 C-terminal residues8.

Additional Product Notes

This product has been verified for IHC-F (Immunohistochemistry - frozen tissue sections) on the NanoString GeoMx® Digital Spatial Profiler. The GeoMx® enables researchers to perform spatial analysis of protein and RNA targets in FFPE and fresh frozen human and mouse samples. For more information about our spatial biology products and the GeoMx® platform, please visit our spatial biology page.

Application References

(PubMed link indicates BioLegend citation)
  1. Nishimura K, et al. 2017. PLoS One. 12(1): e0170568. (ICC)
  2. Jongbloets J, et al. 2017. Nat Commun. 8: 14666. (ICC) PubMed
  3. Liu W.J, et al. 2015. Eur J Histochem. 59(1): 2464. (ICC) PubMed
  4. Chintalapudi SR, et al. 2016. Front Aging Neursci. 8:93. (FC, ICC) PubMed
  5. Ambasudhan R, et al. 2011. Cell Stem Cell. 9(2):113. (IHC, ICC)
  6. Hu X., et al. 2006. Nature Neuroscicene. 9(12):1520. (WB) PubMed
  7. Zechner D., et al. 2003. Develop Biology. 258(2):406. (ICC, IHC)
  8. Lee MK, et al. 1990. Proc. Natl. Acad. Sci. USA 18:7195. (WB)
  9. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  10. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Gai M, et al. 2016. EMBO Rep. 17: 1396 - 1409. PubMed
  2. Nonomura K, et al. 2016. Nature. 541:176-181. PubMed
  3. Ueki J, et al. 2017. Sci Rep. 7:42522. PubMed
  4. Fernandes HJR, et al. 2020. Cell Rep. 33:108263. PubMed
  5. Ko KW, et al. 2020. J Cell Biol. 219:00:00. PubMed
  6. Tilak M, et al. 2021. Molecular Cancer Research. 19(5):757-770. PubMed
  7. Alonso-Barroso E, et al. 2017. Stem Cell Research. 23:173-177. PubMed
  8. Wang YL, et al. 2021. Cell Reports. 36(8):109537. PubMed
  9. Tristan CA, et al. 2020. bioRxiv. . PubMed
  10. Abey A, et al. 2020. Brain Pathol. 31:144. PubMed
  11. Boyer NP, et al. 2018. Eneuro. 55:1847. PubMed
  12. Lee SW et al. 2018. Developmental cell. 46(1):73-84 . PubMed
  13. Chia PH et al. 2018. eLife. 7 pii: e32451. PubMed
  14. Erwig MS, et al. 2019. Elife. 8:. PubMed
  15. Tohgi N, et al. 2017. Cell Cycle. 16:95. PubMed
  16. Nicole O, et al. 2018. Mol Psychiatry. 23:2209. PubMed
  17. Kirihara T, et al. 2019. iScience. 14:301. PubMed
  18. Sanli I, et al. 2018. Cell Rep. 23:337. PubMed
  19. Croteau LP, et al. 2019. Sci Rep. 9:12009. PubMed
  20. Ioannou MS et al. 2019. Cell. 177(6):1522-1535 . PubMed
  21. Paonessa F et al. 2019. Cell reports. 26(3):582-593 . PubMed
  22. de la Cerda B et al. 2019. Stem cell research. 1726:26:00 . PubMed
  23. García‐Peña CM et al. 2018. Frontiers in neuroanatomy. 0.566666667 . PubMed
  24. Coleman JH, et al. 2017. J Comp Neurol. 525:3391. PubMed
  25. Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed
  26. Huang YA et al. 2017. Cell. 168(3):427-441 . PubMed
  27. Hegarty DM, et al. 2018. Pain Rep. 3:e664. PubMed
  28. Dai WJ, et al. 2019. Evid Based Complement Alternat Med. 2019:8413576. PubMed
  29. Wang XW, et al. 2020. Cell Rep. 31:107537. PubMed
  30. Woeste MA, et al. 2019. J Biol Chem. 294:3853. PubMed
  31. Tian R, et al. 2019. Neuron. 104:239. PubMed
  32. Birsa N, et al. 2021. Sci Adv. 7: . PubMed
  33. Castelli LM, et al. 2021. Mol Neurodegener. 16:53. PubMed
  34. Nakayama T, et al. 2021. Cell Rep Med. 2:100421. PubMed
  35. Ye M, et al. 2021. Cell Death Dis. 12:1149. PubMed
  36. Seebauer L, et al. 2022. Int J Mol Sci. 23:. PubMed
  37. Zainul Z, et al. 2022. Sci Rep. 12:3344. PubMed
  38. Ahangari N, et al. 2021. J Neuropathol Exp Neurol. 80:944. PubMed
  39. Dang LT, et al. 2021. Dev Neurobiol. 81:696. PubMed
  40. Tsefou E, et al. 2021. Biochem J. 478:4099. PubMed
  41. Jacquier A, et al. 2022. Acta Neuropathol. 144:707. PubMed
  42. Wang Z, et al. 2022. Research (Wash D C). 2022:9832128. PubMed
  43. Schroeter MS, et al. 2022. MRS Bull. 47:530. PubMed
  44. Piermarini E, et al. 2022. Hum Mol Genet. 31:1844. PubMed
  45. Sun X, et al. 2022. Dev Cell. 57:112. PubMed
  46. Grigor'eva EV 2021. Stem Cell Research. 59:102651. PubMed
  47. Muralidharan H, et al. 2022. J Neurosci. 42:2149. PubMed
  48. Zhang A, et al. 2022. EMBO J. 41:e109187. PubMed
  49. Clements RT 2022. eneuro. 9(2). PubMed
  50. Sosnowski P, et al. 2022. Pharmaceuticals (Basel). 15: . PubMed
  51. Hallacli E, et al. 2022. Cell. 185:2035. PubMed
  52. Lin L, et al. 2022. J Comp Neurol. 530:2820. PubMed
  53. Park SY, et al. 2022. Int J Mol Sci. 23: . PubMed
  54. Hoye ML, et al. 2022. Elife. 11: . PubMed
  55. Wu X, et al. 2022. Cell Rep. 40:111085. PubMed
  56. Januel C, et al. 2022. Cell Mol Life Sci. 79:441. PubMed
  57. Frederico B, et al. 2022. Dev Cell. 57:1957. PubMed
  58. Xu J, et al. 2022. Small. 18:e2203431. PubMed
  59. Fleck JS, et al. 2022. Nature. :. PubMed
  60. Liu S, et al. 2023. CNS Neurosci Ther. 29:228. PubMed
  61. Radwitz J, et al. 2022. Cell Mol Life Sci. 79:575. PubMed
  62. Krasnova OA, et al. 2022. Int J Mol Sci. 23: . PubMed
  63. Vrathasha V, et al. 2022. iScience. 25:105308. PubMed
  64. Liu C, et al. 2022. Cell Mol Life Sci. 79:596. PubMed
  65. Koizumi M, et al. 2022. FASEB J. 36:e22662. PubMed
  66. Herdy JR 2022. Cell Stem Cell. 29(12):1637-1652.e6. PubMed
  67. Zhou Z, et al. 2023. Biol Pharm Bull. 46:102. PubMed
  68. Santiago-Mujika E, et al. 2023. J Alzheimers Dis Rep. 6:739. PubMed
  69. Xue W, et al. 2023. iScience. 26:105898. PubMed
  70. Jin S, et al. 2023. iScience. 26:105885. PubMed
  71. Day C, et al. 2023. Pharmaceuticals (Basel). 16: . PubMed
  72. Willumsen N, et al. 2023. Brain Commun. 5:fcac321. PubMed
  73. Choi EB, et al. 2023. J Biol Chem. 299:102996. PubMed
  74. Ma Y, et al. 2023. Eneuro. 10: . PubMed
  75. Wu W, et al. 2021. Nature. 593:440. PubMed
  76. Le Floch P, et al. 2022. Adv Mater. 34:e2106829. PubMed
  77. Alonso-Alonso S, et al. 2022. Reprod Fertil Dev. 34:576. PubMed
  78. Marrone L, et al. 2022. Hum Mol Genet. 31:2693. PubMed
  79. Hamrangsekachaee M, et al. 2022. ACS Appl Bio Mater. 5:2176. PubMed
  80. Lee J, et al. 2022. Nat Protoc. 17:1266. PubMed
  81. Urbaniak A, et al. 2022. Biomed Pharmacother. 153:113440. PubMed
  82. Dong C, et al. 2022. J Neurosci. 42:8373. PubMed
  83. Krasniewski LK, et al. 2022. Elife. 11:. PubMed
  84. Baek J, et al. 2022. Biomater Sci. 10:6768. PubMed
  85. Li TL, et al. 2022. Biomaterials. 290:121825. PubMed
  86. Cattelani C, et al. 2022. Int J Mol Sci. 23:. PubMed
  87. Chen WJ, et al. 2022. Adv Sci (Weinh). :e2205451. PubMed
  88. Wu J, et al. 2022. Methods Mol Biol. 2593:245. PubMed
  89. Whye D, et al. 2023. Curr Protoc. 3:e641. PubMed
  90. Dong Z, et al. 2023. J Biol Chem. 299:103020. PubMed
  91. Campbell B, et al. 2023. Sci Rep. 13:3000. PubMed
  92. Loan A, et al. 2023. iScience. 26:106093. PubMed
  93. Jimenez-Moreno N, et al. 2023. J Cell Biol. 222:. PubMed
  94. Panzi C, et al. 2023. Toxicon. 228:107110. PubMed
  95. Cossec JC, et al. 2023. Cell Rep. 42:112380. PubMed
  96. Eigenhuis KN, et al. 2023. Front Cell Neurosci. 17:1114420. PubMed
  97. Gilbert-Jaramillo J, et al. 2023. Biol Open. 12:. PubMed
  98. Sim KY, et al. 2023. Sci Rep. 13:6864. PubMed
  99. D'aes T, et al. 2023. Int J Mol Sci. 24:. PubMed
  100. Dawicki-McKenna JM, et al. 2023. Nat Commun. 14:2628. PubMed
  101. Paranjape N, et al. 2023. Sci Rep. 13:7689. PubMed
  102. Nguyen TTM, et al. 2023. iScience. 26:106674. PubMed
  103. Georgelou K, et al. 2023. Biomedicines. 11:. PubMed
  104. Kerkering J, et al. 2023. J Clin Invest. . PubMed
  105. Liang MZ, et al. 2023. Cell Biosci. 13:96. PubMed
  106. Lin CY, et al. 2023. J Food Drug Anal. 31:32. PubMed
  107. Martínez-Torres S, et al. 2023. iScience. 26:106814. PubMed
  108. Dos Santos BL, et al. 2023. Pharmaceutics. 15:. PubMed
  109. Stajkovic N, et al. 2023. J Cell Sci. . PubMed
  110. Drobny S, et al. 2023. Transl Neurodegener. 12:31. PubMed
  111. Zhang M, et al. 2023. Neurosci Bull. . PubMed
  112. Xia F, et al. 2021. Acta Neuropathol Commun. 51:9. PubMed
  113. Shin BC, et al. 2021. Experimental Neurology. 338:113603. PubMed
  114. Wang D, et al. 2020. Journal of Biological Chemistry. 295(25):8374-8386. PubMed
  115. Khoa LTP, et al. 2020. Cell Stem Cell. 27(3):441-458.e10. PubMed
  116. Domènech EB, et al. 2020. Invest Ophthalmol Vis Sci. 61:14:00. PubMed
  117. Elhardt C, et al. 2020. Transl Vis Sci Technol. 9:06. PubMed
  118. Lee SE, et al. 2020. Cell Death Dis. 1.19375. PubMed
  119. Orozco-Díaz R, et al. 2019. PLoS One. 14:e0220393. PubMed
  120. Arber C, et al. 2019. Brain Commun. 1:fcz024. PubMed
  121. Valès S, et al. 2019. EBioMedicine. 49:172. PubMed
  122. Teissier A, et al. 2019. Mol Psychiatry. :. PubMed
  123. Macova I, et al. 2019. J Neurosci. 39:984. PubMed
  124. Inoue SI, et al. 2017. Hum Mol Genet. 26:4715. PubMed
  125. Shepherd DJ et al. 2017. Journal of neuropathology and experimental neurology. 76(8):683-696 . PubMed
  126. Kow Essuman et al. 2017. Neuron. 93(6):1334-1343 . PubMed
  127. Mangold CA et al. 2018. J Neurochem. 144(6):723-735 . PubMed
  128. Levin E et al. 2019. Cell reports. 26(4):1021-1032 . PubMed
  129. Murcia-Belmonte V, et al. 2019. Curr Biol. 29:1149. PubMed
  130. Daoutsali E et al. 2019. Stem Cell Res. 1723:19:00 . PubMed
  131. Ogawa Y et al. 2019. Neurosci Res. pii: S0168-0102(19)30120-8 . PubMed
  132. Tiethof AK, et al. 2018. Toxics. 6:52. PubMed
  133. Boso D, et al. 2019. Theranostics. 9:4860. PubMed
  134. Cha HL, et al. 2019. Mol Brain. 12:57. PubMed
  135. Wang G et al. 2019. eLife. 8 pii: e38730. PubMed
  136. Vinci M, et al. 2018. Nat Med. 24:1204. PubMed
  137. Laussu J, et al. 2017. Neural Dev. 12:10. PubMed
  138. Hu X, et al. 2019. Stem Cell Reports. 12:290. PubMed
  139. Valadas JS et al. 2018. Neuron. 98(6):1155-1169 . PubMed
  140. Ziller MJ, et al. 2018. Cell Stem Cell. 1.304861111. PubMed
  141. Park SY, et al. 2018. Mol Brain. 169:91. PubMed
  142. Babetto E, et al. 2020. Nat Neurosci. 23:1215. PubMed
  143. Eltahir MK, et al. 2022. PLoS One. 17:e0269683. PubMed
  144. Simoes S, et al. 2021. Cell Rep. 37:110182. PubMed
  145. Viais R, et al. 2021. Elife. 10:. PubMed
  146. Lafarga V, et al. 2021. EMBO J. 40:e103311. PubMed
  147. Kim S, et al. 2021. Nat Commun. 12:1807. PubMed
  148. Brown AL, et al. 2022. Nature. 603:131. PubMed
  149. Ruden JB, et al. 2021. Front Mol Neurosci. 14:777049. PubMed
  150. Tseng JH, et al. 2021. Cell Rep. 35:109037. PubMed
  151. Guo B, et al. 2021. Front Cell Dev Biol. 9:768970. PubMed
  152. Li F, et al. 2021. Nat Commun. 12:3845. PubMed
  153. Kishi N, et al. 2016. Nat Commun. 7:10520. PubMed
  154. Nawaz M, et al. 2016. PLoS One. 11: 0148634. PubMed
  155. Tao W, et al. 2020. EMBO Mol Med. 12:e12291. PubMed
  156. Bae B, et al. 2020. RNA. 26:1414. PubMed
  157. Halikere A, et al. 2020. Mol Psychiatry. 25:1406. PubMed
  158. Song JM, et al. 2021. The Journal of Neuroscience. 41(11):2344-2359. PubMed
  159. Benito-Kwiecinski S, et al. 2021. Cell. 184(8):2084-2102.e19. PubMed
  160. Bayerl J, et al. 2021. Cell Stem Cell. . PubMed
  161. Eriksen AZ, et al. 2021. Cell Stem Cell. 28(7):1205-1220.e7. PubMed
  162. Elsayed AK, et al. 2021. Stem Cell Research. 54:102433. PubMed
  163. Lpez-Mrquez A, et al. 2019. Stem Cell Research. 38:101469. PubMed
  164. Sood S, et al. 2020. Proc Natl Acad Sci U S A. 22331:117. PubMed
  165. Lim SH, et al. 2020. J Cell Sci. :133. PubMed
  166. Coste C, et al. 2017. PLoS One. 10.1371/journal.pone.0177962. PubMed
  167. Miranda AM, et al. 2018. Nat Commun. 9:291. PubMed
  168. Liu C, et al. 2018. Stem Cell Reports. 4:43. PubMed
  169. Lee SY et al. 2018. Stem cell research. 30:145-149 . PubMed
  170. Vitali I et al. 2018. Cell. 174(5):1264-1276 . PubMed
  171. Roselló-Busquets C, et al. 2019. Front Cell Neurosci. 13:40. PubMed
  172. Stepp MA, et al. 2018. Int J Mol Sci. 19:12. PubMed
  173. Miltner AM, et al. 2019. Int J Mol Sci. 20. PubMed
  174. Canali G, et al. 2018. Hum Mol Genet. 27:1941. PubMed
  175. Haverfield JT, et al. 2017. Reprod Fertil Dev. 29:609. PubMed
  176. Arellano‐Viera E et al. 2019. Stem cell research. 1726:10:00 . PubMed
  177. Ribic A et al. 2019. Cell reports. 26(2):381-393 . PubMed
  178. Varga E et al. 2017. Stem cell research. 25:30-33 . PubMed
  179. Nguyen HX et al. 2014. The Journal of comparative neurology. 522(12):2767-83 . PubMed
  180. Bonnefont J, et al. 2019. Neuron. 103:1096. PubMed
  181. Giandomenico SL, et al. 2019. Nat Neurosci. 22:669. PubMed
  182. Stratton JA, et al. 2020. Front Aging Neurosci. 0.620833333. PubMed
  183. Yun T, et al. 2021. Cell Death Discov. 7:257. PubMed
  184. Herbst WA, et al. 2021. J Cell Biol. 220:. PubMed
  185. Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed
  186. Earley AM, et al. 2021. Sci Rep. 11:22257. PubMed
  187. Ramirez S, et al. 2021. STAR Protoc. 2:100987. PubMed
  188. Valenzuela M, et al. 2022. Stem Cell Res Ther. 13:261. PubMed
  189. Richardson RT, et al. 2021. Sci Rep. 11:11229. PubMed
  190. Guo X, et al. 2021. Cell. 184:4299. PubMed
  191. Vilallongue N, et al. 2022. Nat Commun. 13:6040. PubMed
  192. Lennox AL, et al. 2020. Neuron. 404:106. PubMed
  193. Pecori F, et al. 2021. Cell Reports. 36(2):109361. PubMed
  194. Aarts CEM, et al. 2021. Stem Cell Research. 54:102444. PubMed
  195. Zhang K, et al. 2021. Neuron. 109(12):1949-1962.e6. PubMed
  196. Aprigliano R, et al. 2021. Cell Reports Medicine. 2(4):100240. PubMed
  197. Pantier R, et al. 2021. Molecular Cell. 81(4):845-858.e8. PubMed
  198. Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed
  199. Toma JS, et al. 2020. Eneuro. 7:00. PubMed
  200. Solis-Castro OO, et al. 2020. Stem Cells Transl Med. 1.390277778. PubMed
  201. Ucuncu E, et al. 2020. Nat Commun. 4.685416667. PubMed
  202. LI Y, et al. 2017. Proc Natl Acad Sci U S A. 114(2):E209-E218. PubMed
  203. Jiang G, et al. 2016. Stem Cells Trans Med. 5(12):1595-1606. PubMed
  204. Martin C, et al. 2016. Genes Dev. 30: 2158 - 2172. PubMed
  205. Kida H, et al. 2016. Cereb Cortex. 10.1093/cercor/bhw134. PubMed
  206. Savino E, et al. 2020. Cell Death Dis. 1.052777778. PubMed
  207. Saito K, et al. 2019. Cell Rep. 29:1555. PubMed
  208. Lilian SJ, et al. 2019. J Assoc Res Otolaryngol. 20:133. PubMed
  209. Milbreta U, et al. 2019. Mol Ther. 27:411. PubMed
  210. Arai Y, et al. 2019. Cell Rep. 29:645. PubMed
  211. Bucan V, et al. 2019. Int J Mol Med. 43:593. PubMed
  212. Petkovich DA et al. 2017. Cell metabolism. 25(4):954-960 . PubMed
  213. Auboyer L et al. 2019. Stem Cell Res. 1727:38:00 . PubMed
  214. Tomassoni–Ardori F, et al. 2019. Elife. 8:e46677. PubMed
  215. Van Der Raadt J, et al. 2019. Nucleic Acids Res. 47:5587. PubMed
  216. Raspa A, et al. 2019. CNS Neurosci Ther. 25:86. PubMed
  217. González C, et al. 2018. Mol Psychiatry. 23:2363. PubMed
  218. Liu H, et al. 2019. Front Cell Neurosci. 13:60. PubMed
  219. Mura M et al. 2018. Stem cell research. 29:170-173 . PubMed
  220. Hermanto Y et al. 2018. Journal of neuroscience research. 96(5):863-874 . PubMed
  221. Playne R, et al. 2018. J Stem Cells Regen Med. 7:e36998. PubMed
  222. Allende ML, et al. 2018. J Lipid Res. 59:550. PubMed
  223. Masumoto K, et al. 2022. Sci Rep. 12:10351. PubMed
  224. McClellan S, et al. 2021. Invest Ophthalmol Vis Sci. 62:14. PubMed
  225. Hagihara H, et al. 2021. Cell Rep. 37:109820. PubMed
  226. Boussaad I, et al. 2021. Sci Rep. 11:1439. PubMed
  227. Savino E, et al. 2021. Cells. 10:. PubMed
  228. Liu X, et al. 2021. Cell Prolif. 54:e13124. PubMed
  229. Doron-Mandel E, et al. 2021. EMBO J. 40:e107158. PubMed
  230. Kim K, et al. 2015. PLoS One. 10: 0142693. PubMed
  231. Mazzulli J, et al. 2016. Proc Natl Acad Sci U S A. 113: 1931 - 1936. PubMed
  232. Soares V, et al. 2016. Neuro Oncology. 10.1093/neuonc/now099. PubMed
  233. Mikami Y, et al. 2016. EBioMedicine. 11: 253-261. PubMed
  234. Pal-Ghosh S, et al. 2020. Invest Ophthalmol Vis Sci. 61:01:00. PubMed
  235. Janz A, et al. 2021. Stem Cell Research. 53:102256. PubMed
  236. Janssens S, et al. 2018. mSystems. 3. PubMed
  237. Thomas RA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  238. Tripathy R, et al. 2018. Neuron. 100:1354. PubMed
  239. Lenz KM, et al. 2018. J Neurosci. 38:8044. PubMed
  240. Nam H et al. 2019. Elife. 8 pii: e46683. PubMed
  241. Boucherie C, et al. 2018. Mol Psychiatry. 23:723. PubMed
  242. Leibinger M et al. 2019. Commun Biol. 0.304166667 . PubMed
  243. Mura M et al. 2019. Stem Cell Res. 1727:37:00 . PubMed
  244. Hansen M et al. 2017. Stem cell research. 25:34-37 . PubMed
  245. Yang SC, et al. 2019. FASEB J. 33:10577. PubMed
  246. Qiang L, et al. 2019. Hum Mol Genet. 28:1136. PubMed
  247. Iwasa N, et al. 2021. Front Cell Neurosci. 15:605030. PubMed
  248. Boshans LL, et al. 2021. Sci Rep. 11:3552. PubMed
  249. Weiss FD, et al. 2021. Nat Commun. 12:2919. PubMed
  250. Mallach A, et al. 2021. Cells. 10:. PubMed
  251. Hernandez-Clavijo A, et al. 2022. Cell Physiol Biochem. 56:254. PubMed
  252. Wang W, et al. 2021. EMBO J. 40:e106771. PubMed
  253. Lin YC, et al. 2021. Nat Neurosci. 24:1077. PubMed
  254. Lim JY, et al. 2021. Stem Cell Res Ther. 12:402. PubMed
  255. Mifsud KR, et al. 2021. Nat Commun. 12:4737. PubMed
  256. Li Y, et al. 2022. Front Neurosci. 16:945277. PubMed
  257. Mura M, et al. 2019. Stem Cell Research. 42:101658. PubMed
  258. Alkobtawi M, et al. 2021. Cell Reports. 35(12):109289. PubMed
  259. Li W, et al. 2021. Stem Cell Research. 53:102259. PubMed
  260. Haas M, et al. 2016. Cell Rep. 15:2251-2265. PubMed
  261. Itoh Y, et al. 2016. Proc Natl Acad Sci U S A. 113: 2955 - 2964. PubMed
  262. Nagao M, et al. 2016. Nat Commun. 7:11102. PubMed
  263. Taverna E, et al. 2016. Sci Rep. 6:21206. PubMed
  264. Ulbrich L, et al. 2016. Biochem J. 473: 423 - 434. PubMed
  265. Barry D, et al. 2012. J Neurosci. 32:6209-6219. PubMed
  266. Catanese A, et al. 2019. Autophagy. 15:1719. PubMed
  267. Pettingill P, et al. 2019. Brain. 142:3852. PubMed
  268. Wang SE, et al. 2019. Exp Neurobiol. 28:537. PubMed
  269. Song Z, et al. 2019. Front Cell Dev Biol. 0.352083333. PubMed
  270. Wang L et al. 2016. The Journal of comparative neurology. 524(11):2322-34 . PubMed
  271. Hansen M et al. 2017. Stem cell research. 25:42-45 . PubMed
  272. Herdy J et al. 2019. Elife. 8 pii: e41356. PubMed
  273. Vicario N et al. 2019. Molecular neurobiology. 56(11):7338-7354 . PubMed
  274. Child KM et al. 2018. The Journal of Neuroscience. 38(31):6806-6824 . PubMed
  275. Fujitani M, et al. 2017. Mol Psychiatry. 22:364. PubMed
  276. Hockman D, et al. 2018. Dev Biol. 444:s308. PubMed
  277. Barbiero I, et al. 2017. Hum Mol Genet. 26:3520. PubMed
  278. Coleman JH, et al. 2019. J Neurosci. 39:814. PubMed
  279. Luo C et al. 2019. eLife. 8 pii: e40197. PubMed
  280. Liu L et al. 2017. Cell metabolism. 26(5):719-737 . PubMed
  281. Knudsen JG et al. 2018. Cell metabolism. 29(2):430-442 . PubMed
  282. Millan‐Zambrano G et al. 2018. Molecular cell. 72(4):625-635 . PubMed
  283. Sevilla A et al. 2018. Stem cell research. 29:99-102 . PubMed
  284. Muthusamy N, et al. 2018. Sci Rep. 8:1766. PubMed
  285. Iyer AA, et al. 2022. Elife. 11:. PubMed
  286. Cheng Y, et al. 2022. Nat Commun. 13:4418. PubMed
  287. Ramirez S, et al. 2021. Cells. 10:. PubMed
  288. Wareham LK, et al. 2021. iScience. 24:103141. PubMed
  289. Abe K, et al. 2021. Biophys J. 120:3566. PubMed
  290. Caiazzo M, et al. 2016. Nat Mater. 0.1038/nmat4536. PubMed
  291. Fan C, et al. 2016. Sci Rep. 6:19579. PubMed
  292. Vanderperre B, et al. 2016. PLoS Genet. 12: 1006056. PubMed
  293. Wang T, et al. 2016. Nat Commun. 7: 12976. PubMed
  294. Pei S, et al. 2016. Sci Rep. 6:33822. PubMed
  295. M Rodriguez, S Noctor, E Muñoz 2016. PLoS One. 11:e0167063. PubMed
  296. Ahn LY, et al. 2021. J Neurosci Res. 99:110. PubMed
  297. Black JB, et al. 2020. Cell Rep. 33:108460. PubMed
  298. Birkhoff JC, et al. 2020. Hum Mol Genet. 29:2535. PubMed
  299. Pereiro X, et al. 2020. Cells. 9:00. PubMed
  300. Berenguer-Escuder C, et al. 2020. Human Molecular Genetics. 29(8):1353-1364. PubMed
  301. Tapias A, et al. 2021. eLife. 10:00. PubMed
  302. Dong L, et al. 2021. Stem Cell Research. 53:102260. PubMed
  303. Zhang T, et al. 2021. STAR Protocols. 2(1):100346. PubMed
  304. Arribas-Carreira L, et al. 2019. Stem Cell Research. 39:101503. PubMed
  305. Schoger E, et al. 2021. Stem Cell Research. 56:102518. PubMed
  306. Klima S, et al. 2020. ALTEX. . PubMed
  307. Kuwahara H, et al. 2018. Sci Rep. 8:4377. PubMed
  308. Anne Jacob et al. 2018. Journal of neurochemistry. 146(3):251-268 . PubMed
  309. Lehrman EK et al. 2018. Neuron. 100(1):120-134 . PubMed
  310. Valdez C, et al. 2017. Hum Mol Genet. 26:4861. PubMed
  311. Moakley D, et al. 2019. Sci Rep. 9:10835. PubMed
  312. Malkemper EP, et al. 2018. Biol Open. 7:bio034462. PubMed
  313. Stratton JA et al. 2018. Cell reports. 24(10):2561-2572 . PubMed
  314. Neurohr GE, et al. 2019. Cell. 176:1083. PubMed
  315. Hermanto Y et al. 2019. Journal of neuroscience research. 97(7):828-845 . PubMed
  316. An D, et al. 2019. Elife. 8:e44423. PubMed
  317. Voronova A et al. 2017. Neuron. 94(3):500-516 . PubMed
  318. Hilla AM et al. 2017. The Journal of Neuroscience. 37(25):6113-6124 . PubMed
  319. Bustos F, et al. 2018. Cell Rep. 2.06875. PubMed
  320. Mayanagi T, et al. 2020. Front Cell Neurosci. 0.933333333. PubMed
  321. Arsić A, et al. 2020. Sci Rep. 10:6441. PubMed
  322. Edwards G, et al. 2020. Cell Death Dis. 11:254. PubMed
  323. Nishimura K, et al. 2017. PLoS One. 12:e0170568. PubMed
  324. Roselló-Busquets C, et al. 2020. Front Mol Neurosci. 13:56. PubMed
  325. Wang X, et al. 2019. Front Neurosci. 1.324305556. PubMed
  326. Guerriero I, et al. 2021. PLoS One. 16:e0253828. PubMed
  327. Diao X, et al. 2021. Cells. 10:. PubMed
  328. Lamotte JD, et al. 2021. Front Pharmacol. 11:617867. PubMed
  329. Paik S, et al. 2021. Biomedicines. 9:. PubMed
  330. Nehme R, et al. 2022. Nat Commun. 13:3690. PubMed
  331. Xia L, et al. 2022. Front Pharmacol. 13:881195. PubMed
  332. Zhang L, et al. 2022. Front Aging Neurosci. 14:926485. PubMed
  333. Lu P, et al. 2022. Invest Ophthalmol Vis Sci. 63:18. PubMed
  334. Heuermann ML, et al. 2022. Front Cell Neurosci. 16:841864. PubMed
  335. McSweeney D, et al. 2022. iScience. 25:105187. PubMed
  336. Lasman L, et al. 2020. Genes Dev. 34:1373. PubMed
  337. Wong HS, et al. 2021. Cell. . PubMed
  338. Kim JW, et al. 2020. Cell Stem Cell. 27(4):633-645.e7. PubMed
  339. Evsen L, et al. 2020. Development. 147:00:00. PubMed
  340. Huang YA, et al. 2020. J Cell Sci. 133:00:00. PubMed
  341. Levin G, et al. 2020. Front Bioeng Biotechnol. 0.663888889. PubMed
  342. Seo HH, et al. 2020. Emerg Microbes Infect. 1.724305556. PubMed
  343. Laura Kerosuo, Marianne E. Bronner 2016. Cell Rep. 17:2648-2659. PubMed
  344. George L, et al. 2016. Dev Biol. 413:70-85. PubMed
  345. Ferletta M, et al. 2011. Int J Cancer. 129:45-60. PubMed
  346. Banal C, et al. 2020. Stem Cell Research. 72.78888889. PubMed
  347. Zhao J, et al. 2020. Aging (Albany NY). 12:5590. PubMed
  348. Themeli M, et al. 2020. Stem Cell Reports. 14:300. PubMed
  349. Ding D, et al. 2020. J Otol. 15:36. PubMed
  350. Ilouz R et al. 2017. eLife. 6 pii: e17681. PubMed
  351. Kwart D et al. 2019. Neuron. 104(2):256-270 . PubMed
  352. Di Bella DJ, et al. 2019. Cell Rep. 28:2264. PubMed
  353. Velychko S et al. 2019. Cell reports. 27(1):30-39 . PubMed
  354. Kim J, et al. 2018. Development. 145. PubMed
  355. Yang T et al. 2018. Cell reports. 24(10):2694-2708 . PubMed
  356. Cheng LS, et al. 2017. Pediatr Res. 81:838. PubMed
  357. Augé E, et al. 2018. Sci Rep. 8:13525. PubMed
  358. Shin BC et al. 2018. The Journal of Neuroscience. 38(44):9579-9599 . PubMed
  359. Cárdenas A et al. 2018. Cell. 174(3):590-606 . PubMed
  360. Goffena J, et al. 2018. Nat Commun. 9:889. PubMed
  361. Ogawa Y, et al. 2017. PLoS One. 12(6):e0178978. PubMed
  362. Ha GH, et al. 2022. Aging (Albany NY). 14:. PubMed
  363. Meyer Zu Reckendorf S, et al. 2022. J Neurosci. 42:2474. PubMed
  364. van Niekerk EA, et al. 2022. Cell Rep Methods. 2:100255. PubMed
  365. Nouri P, et al. 2022. Cells. 11:. PubMed
  366. Amo-Aparicio J, et al. 2021. Theranostics. 11:9805. PubMed
  367. Fagerlund I, et al. 2021. Cells. 11:. PubMed
  368. Petrovic A, et al. 2022. Int J Mol Sci. 23:. PubMed
  369. Colombo S, et al. 2022. Development. 149:. PubMed
  370. Sidoli M, et al. 2021. J Neurosci. 41:4536. PubMed
  371. Simone R, et al. 2021. Nature. 594:117. PubMed
  372. Li A, et al. 2021. STAR Protoc. 2:100580. PubMed
  373. Osuka S, et al. 2021. J Clin Invest. 131: . PubMed
  374. Wirt S, et al. 2010. J Cell Biol. 191:809-825. PubMed
  375. Wang Q, et al. 2016. Sci Rep. 6:19003. PubMed
  376. Petracca Y, et al. 2016. Development. 143: 880 - 891. PubMed
  377. Lalli M, et al. 2016. Hum Mol Genet. 25: 1294-1306. PubMed
  378. Thakurela S, et al. 2016. Sci Rep. 6: 25828. PubMed
  379. Bedogni F, et al. 2016. Cereb Cortex. 26: 2517 - 2529. PubMed
  380. Landegger L, et al. 2017. Nat Biotechnol. 35:280-284. PubMed
  381. Pournasr B, et al. 2020. Stem Cell Res. 48:101953. PubMed
  382. Trapecar M, et al. 2021. Sci Adv. 7:00. PubMed
  383. Smith KE, et al. 2020. Journal of Neuroscience Research. 99(2):679-698. PubMed
  384. Isaja L, et al. 2021. Stem Cell Research. 53:102325. PubMed
  385. Elsayed AK, et al. 2021. Stem Cell Research. 56:102500. PubMed
  386. Bargagna-Mohan P, et al. 2020. J Neurosci Res. . PubMed
  387. Lee N, et al. 2021. Biochem Biophys Rep. 100973:26. PubMed
  388. Chau KF, et al. 2018. Elife. 19:E663. PubMed
  389. Sun S et al. 2018. Cell. 174(5):1247-1263 . PubMed
  390. Yi‐Lan Weng et al. 2018. Neuron. 97(2):313-325 . PubMed
  391. Bachmann SO, et al. 2019. Transl Psychiatry. 9:29. PubMed
  392. Sabo JK, et al. 2017. Ann Neurol. 81:560. PubMed
  393. Gao L, et al. 2019. Front Cell Neurosci. 13:316. PubMed
  394. Shao Q et al. 2019. PLoS One. 14(6):e0218811 . PubMed
  395. Mohlin S, et al. 2019. EMBO Mol Med. 11:e10058. PubMed
  396. Ibañez Rodriguez MP et al. 2018. The Journal of comparative neurology. 526(15):2462-2481 . PubMed
  397. Duan RS, et al. 2018. Cell Death Differ. 25:1598. PubMed
  398. Pollen AA, et al. 2019. Cell. 176:743. PubMed
  399. Corman A, et al. 2019. Cell Chem Biol. 26:235. PubMed
  400. Molotkov A et al. 2017. Developmental cell. 41(5):511-526 . PubMed
  401. Yang C, et al. 2020. Neuron. 105:276. PubMed
  402. Marchetta P, et al. 2020. Front Aging Neurosci. 12:83. PubMed
  403. Zheng Z, et al. 2021. Cell Biol Toxicol. Online ahead of prin. PubMed
  404. Lim SH, et al. 2020. J Cell Sci. . PubMed
  405. Salti A, et al. 2021. Cells. 10:. PubMed
  406. Araki R, et al. 2021. Heliyon. 7:e08071. PubMed
  407. Ye E, et al. 2022. Int J Oncol. 60:. PubMed
  408. Taïb S, et al. 2022. Elife. 11:. PubMed
  409. Bérenger-Currias NM, et al. 2022. J Tissue Eng. 13:20417314221103042. PubMed
  410. Urciuolo A, et al. 2020. Nat Biomed Eng. 4:901. PubMed
  411. Sadick JS, et al. 2020. Ann Biomed Eng. 48:2218. PubMed
  412. Lecomte A, et al. 2020. Adv Biosyst. e2000114:4. PubMed
  413. Wang L, et al. 2020. Nat Commun. 3.2625. PubMed
  414. Sheehan CJ, et al. 2020. Development. 147:00:00. PubMed
  415. Zabolocki M, et al. 2020. Nat Commun. 4.3125. PubMed
  416. Liu R, et al. 2021. Oncol Lett. 21:06. PubMed
  417. Zhang X, et al. 2020. Sci Adv. 6:00. PubMed
  418. Sadick J, et al. 2016. Sci Rep. 6: 33999. PubMed
  419. Guo S, Du Y, Liu X 2016. Nat Commun. 7:12230. PubMed
  420. Kushwaha R, et al. 2016. Stem Cell Reports. 6:772-783. PubMed
  421. Paquet D, et al. 2016. Nature. 533: 125-129. PubMed
  422. Binder Z, et al. 2016. PLoS One. 11: 0150271. PubMed
  423. He H, et al. 2016. J Neurosci. 36: 3079 - 3091. PubMed
  424. Khong ZJ, et al. 2020. Cell Death Dis. 11:182. PubMed
  425. Pinheiro H, et al. 2018. Front Pharmacol. 0.527083333. PubMed
  426. Ichihara–Tanaka K, et al. 2017. J Histochem Cytochem. 65:513. PubMed
  427. Harrington AJ et al. 2016. eLife. 5 pii: e20059. PubMed
  428. Michael Lerche et al. 2017. Structure (London, England : 1993). 25(8):1175-1186 . PubMed
  429. Larhammar M et al. 2017. eLife. 6 pii: e20725. PubMed
  430. Lavado A et al. 2018. Dev Cell. 47(5):576-591 . PubMed
  431. Freeman S et al. 2019. EMBO Rep. 20(9):e47097 . PubMed
  432. Kaur T, et al. 2019. Front Neurosci. 13:620. PubMed
  433. Nash B et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  434. Sarkar C, et al. 2019. Autophagy. N/A. PubMed
  435. Tramarin M, et al. 2018. Hum Mol Genet. 27:2052. PubMed
  436. Xue J, et al. 2017. ACS Appl Mater Interfaces. 9:12299. PubMed
  437. Toda T, et al. 2017. Cell Stem Cell. 21:618. PubMed
  438. Amaral JD, et al. 2019. Front Chem. 7:15. PubMed
  439. Wang XW, et al. 2018. Cell Rep. 24:2540. PubMed
  440. Tavano S et al. 2018. Neuron. 97(6):1299-1314 . PubMed
  441. Luisier R, et al. 2018. Nat Commun. 8:6458. PubMed
  442. Fujiwara N, et al. 2022. Pediatr Surg Int. 39:18. PubMed
  443. Zhu Z, et al. 2022. Aging Cell. 21:e13587. PubMed
  444. Schaeffer J, et al. 2022. Front Cell Dev Biol. 10:917589. PubMed
  445. Li J, et al. 2021. Neural Plast. 2021:4894881. PubMed
  446. Wilmerding A, et al. 2021. Int J Mol Sci. 22:. PubMed
  447. Hu D, et al. 2021. Nat Commun. 12:5305. PubMed
  448. Russo-Savage L, et al. 2020. Neurobiol Aging. 95:69. PubMed
  449. Pinto M, et al. 2016. J Cell Biol. 212: 789 - 801. PubMed
  450. Okamoto M, et al. 2016. Nat Commun. 7: 11349. PubMed
  451. Liu X, et al. 2016. Nat Commun. 7:11508. PubMed
  452. Grandi FC, et al. 2020. Front Mol Neurosci. 0.599305556. PubMed
  453. Ewan EE, et al. 2021. Sci Rep. 0.718055556. PubMed
  454. Brievac D, et al. 2020. Journal of Neurochemistry. 157(3):666-683. PubMed
  455. Hu Z, et al. 2020. Cell Rep. 107657:31. PubMed
  456. Lehtonen Ŝ et al. 2018. Stem cell research. 30:96-99 . PubMed
  457. Qiang L et al. 2018. Current biology : CB. 28(13):2181-2189 . PubMed
  458. Hor JH, et al. 2018. Cell Death Dis. 9:1100. PubMed
  459. Gupta S et al. 2017. Journal of neurochemistry. 145(3):188-203 . PubMed
  460. Howlett EH, et al. 2017. Hum Mol Genet. 26:4340. PubMed
  461. Zunke F et al. 2017. Neuron. 97(1):92-107 . PubMed
  462. Fernandes KA, et al. 2018. Exp Eye Res. 171:54. PubMed
  463. Linkous A et al. 2019. Cell reports. 26(12):3203-3211 . PubMed
  464. Pronin A, et al. 2019. Front Mol Neurosci. 12:36. PubMed
  465. Meijer M et al. 2019. Cell Rep. 27(7):2199-2211 . PubMed
  466. Lin CI et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  467. Auboyer L et al. 2019. Stem Cell Res. 1723:41:00 . PubMed
  468. Kurtenbach S et al. 2017. PloS one. 12(11):e0187576 . PubMed
  469. Yu M et al. 2017. Cell research. 27(12):1441-1465 . PubMed
  470. Huh CJ et al. 2016. eLife. 5 pii: e18648. PubMed
  471. Li J, et al. 2018. Neural Plast. 2018:6890613. PubMed
  472. Chen YT, et al. 2019. Stem Cell Res Ther. 0.6875. PubMed
  473. Syal C, et al. 2020. Theranostics. 10:6337. PubMed
  474. de Matos AM, et al. 2020. J Med Chem. 63:11663. PubMed
  475. Calamini B, et al. 2021. Dis Model Mech. 14:. PubMed
  476. Gandhi S, et al. 2021. Development. 148:. PubMed
  477. Stern S, et al. 2021. Neuron. 109:3436. PubMed
  478. Nath M, et al. 2022. Eneuro. 9:. PubMed
  479. Xu PF, et al. 2021. Nature Communications. 12(1):3277. PubMed
  480. Anderson EM, et al. 2021. Addiction Biology. :e13060. PubMed
  481. Lin NH, et al. 2021. The FASEB Journal. 35(5):e21614. PubMed
  482. Leibinger M, et al. 2021. Nature Communications. 12(1):391. PubMed
  483. Huang S, et al. 2020. Cell Rep. 33:108394. PubMed
  484. Rubio A, et al. 2016. Sci Rep. 6:37540. PubMed
  485. Intoh A, et al. 2016. Hum Mol Genet. 10.1093/hmg/ddw053. PubMed
  486. Sancho-Martinez I, et al. 2016. Nat Commun. 7:10743. PubMed
  487. Jouhilahti E, et al. 2008. J Histochem Cytochem. 56:1113-1119. PubMed
  488. Gilliam EA, et al. 2020. American Journal of Physiology-Gastrointestinal and Liver Physiology. 319(2):G261-G279.. PubMed
  489. Dionisi C, et al. 2020. Sci Rep. 10:7752. PubMed
  490. Lindsay CD, et al. 2019. Acta Biomater. 95:225. PubMed
  491. Makdissy N, et al. 2018. Stem Cell Res Ther. 0.466666667. PubMed
  492. Mettang M, et al. 2018. FASEB J. 32:1916. PubMed
  493. Chen X et al. 2017. Developmental cell. 43(5):563-576 . PubMed
  494. Hegarty DM, et al. 2017. J Comp Neurol. 525:2019. PubMed
  495. Tsuboi M, et al. 2018. Dev Cell. 47:758. PubMed
  496. Sharma N et al. 2019. Neuron. 102(2):390-406 . PubMed
  497. Mo J, et al. 2017. Invest Ophthalmol Vis Sci. 58:137. PubMed
  498. Rhee HJ et al. 2019. Cell Rep. 27(7):2212-2228 . PubMed
  499. Makar T, et al. 2018. Stem Cell Res Ther. 9:127. PubMed
  500. Debadrita Bhattacharya et al. 2018. eLife. 7 pii: e40556. PubMed
  501. Zahr SK et al. 2018. Neuron. 97(3):520-537 . PubMed
  502. Kim YJ, et al. 2018. Neuron. 100:1180. PubMed
  503. Contreras E, et al. 2022. Cell Tissue Res. :. PubMed
  504. Sluysmans S, et al. 2021. Mol Biol Cell. 32:ar34. PubMed
  505. Ma C, et al. 2022. Int J Mol Med. 50:. PubMed
  506. Khan M, et al. 2021. Cell. 184:5932. PubMed
  507. Xue Y, et al. 2016. Nat Neurosci. 19: 807-15. PubMed
  508. Muscat A, et al. 2016. Clin Cancer Res. 22: 3560 - 3570. PubMed
  509. Sandor C, et al. 2017. Hum Mol Genet. 10.1093/hmg/ddw412. PubMed
  510. Ingersoll MA, et al. 2020. Sci Adv. 6:00. PubMed
  511. Jiang B, et al. 2020. Sci Adv. 6:00. PubMed
  512. Barbuti PA, et al. 2020. Cells. 9:00. PubMed
  513. Vila-Cejudo M, et al. 2018. Journal of Assisted Reproduction and Genetics. 36(1):99-111. PubMed
  514. Koinuma S, et al. 2020. Journal of Neurochemistry. 157(4):1196-1206. PubMed
  515. Dementyeva EV, et al. 2021. Stem Cell Research. 53:102344. PubMed
  516. Han JS, et al. 2020. Proc Natl Acad Sci U S A. 23073:117. PubMed
  517. Gupta S, et al. 2021. STAR Protoc. 100319:2. PubMed
  518. Hertzano R, et al. 2020. Laryngoscope. . PubMed
  519. Flaherty E,et al. 2017. NPJ Schizophr.. 10.1038/s41537-017-0033-5. PubMed
  520. Ryan T, et al. 2018. Nat Commun. 9:817. PubMed
  521. Moon KH et al. 2018. Developmental cell. 44(1):13-28 . PubMed
  522. Xu Z, et al. 2019. Front Neurosci. 12:970. PubMed
  523. Joanna Ruth Appel et al. 2018. The Journal of Neuroscience. 38(26):5949-5968 . PubMed
  524. Vyas P, et al. 2019. Sci Rep. 9:5549. PubMed
  525. Zhang N, et al. 2019. Adv Sci (Weinh). 6:1800808. PubMed
  526. Singh K, et al. 2018. Front Mol Neurosci. 11:30. PubMed
  527. Friocourt F et al. 2019. The Journal of comparative neurology. 527(12):2009-2029 . PubMed
  528. Weng YL, et al. 2017. Neuron. 94:337. PubMed
  529. Espuny‐Camacho I et al. 2017. Neuron. 93(5):1066-1081 . PubMed
  530. Park JH, et al. 2018. Mol Cell Biol. 38:e00217. PubMed
  531. Ozaki K, et al. 2019. Invest Ophthalmol Vis Sci. 60:4151. PubMed
  532. Llères D, et al. 2019. Genome Biol. 1.022222222. PubMed
  533. Dourado NS, et al. 2020. Front Aging Neurosci. 12:119. PubMed
  534. Götzl JK, et al. 2018. Mol Neurodegener. 13:48. PubMed
  535. Borys BS, et al. 2021. Stem Cell Res Ther. 12:55. PubMed
  536. Little JN, et al. 2021. J Neurosci. 41:3344. PubMed
  537. Sanchez CG, et al. 2021. Commun Biol. 4:736. PubMed
  538. Wang L, et al. 2021. Nat Med. 27:1600. PubMed
  539. Sepehrimanesh M, et al. 2021. STAR Protoc. 2:100917. PubMed
  540. Barbuti PA, et al. 2021. Sci Rep. 11:21946. PubMed
  541. Meng X, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  542. Argolo DS, et al. 2022. Int J Tryptophan Res. 15:11786469211069946. PubMed
  543. Li Y, et al. 2022. J Cell Biol. 221:. PubMed
  544. Yamamoto Y, et al. 2022. Life Sci Alliance. 5:. PubMed
  545. Chen J, et al. 2021. Int J Mol Sci. 23:. PubMed
  546. Zhang H, et al. 2022. Elife. 11:. PubMed
  547. Tang J, et al. 2022. Antioxidants (Basel). 11:. PubMed
  548. Cuddy LK, et al. 2021. STAR Protoc. 100340:2. PubMed
  549. Matern MS, et al. 2020. Development. :147. PubMed
  550. Nikulina E, et al. 2020. FEBS Lett. 1389:594. PubMed
  551. Ghita L, et al. 2021. Journal of Neuroscience Research. :. PubMed
  552. Simon DJ, et al. 2021. Developmental Cell. 56(7):976-984.e3. PubMed
  553. Maor-Nof M, et al. 2021. Cell. 184(3):689-708.e20. PubMed
  554. Kraemer BR, et al. 2020. Neuroscience. 453:222-236. PubMed
  555. Schörnig M, et al. 2021. Elife. 10:00. PubMed
  556. Camilieri-Asch V, et al. 2020. Front Neuroanat. 14:560534. PubMed
  557. Durak O, et al. 2016. Nat Neurosci. 19:1477-1488. PubMed
  558. Drobish J, et al. 2016. Toxicol Sci. 154(2):309-319. PubMed
  559. Marchetto M, et al. 2016. Mol Psychiatry. 10.1038/mp.2016.95. PubMed
  560. Wang W, et al. 2016. Nat Commun. 7:10936. PubMed
  561. Tanimoto R, et al. 2016. Sci Rep. 6:22071. PubMed
  562. Stathakos P, et al. 2020. Autophagy. :1. PubMed
  563. Huang YA, et al. 2019. J Neurosci. 39:7408. PubMed
  564. Dang LT, et al. 2020. Front Cell Neurosci. 14:122. PubMed
  565. Sloan SA et al. 2017. Neuron. 95(4):779-790 . PubMed
  566. Shao Q et al. 2017. The Journal of Neuroscience. 37(23):5620-5633 . PubMed
  567. Wu JS et al. 2017. The Journal of comparative neurology. 526(3):425-438 . PubMed
  568. Wu C, et al. 2019. Cell Rep. 26:1143. PubMed
  569. Vassilev V, et al. 2017. Dev Cell. 43:463. PubMed
  570. Kim J, et al. 2017. Histochem Cell Biol. 148:489. PubMed
  571. Thayer JA, et al. 2019. Autophagy. 7:1-14. PubMed
  572. Liu WA, et al. 2018. Genes Dev. 32:763. PubMed
  573. Trajkovic K, et al. 2019. PLoS One. 14:e0211727. PubMed
  574. Oksanen M et al. 2018. Stem cell research. 31:181-185 . PubMed
  575. Johansson E, et al. 2017. Cell Rep. 10.1016/j.celrep.2017.07.049. PubMed
  576. Reyes RV, et al. 2022. Front Neurosci. 16:908719. PubMed
  577. He B, et al. 2021. J Anat. 239:913. PubMed
  578. Arsic A, et al. 2022. Nat Commun. 13:314. PubMed
  579. Calamini B, et al. 2021. Dis Model Mech. . PubMed
  580. Brown D, et al. 2021. Neurotherapeutics. 18:387. PubMed
  581. Wang M, et al. 2021. Neuron. 109:257. PubMed
  582. Ren J, et al. 2021. Cells. 10:. PubMed
  583. Cui K, et al. 2020. Microsyst Nanoeng. 6:49. PubMed
  584. Quintes S, et al. 2016. Nat Neurosci. 10.1038/nn.4321. PubMed
  585. Demais V, et al. 2016. J Neurosci. 36: 8012 - 8025. PubMed
  586. Borromeo M, et al. 2016. Cell Rep. 16:1259-1272. PubMed
  587. Borgs L, et al. 2016. Sci Rep. 6: 33377. PubMed
  588. Enriquez‐Rios V et al. 2017. The Journal of Neuroscience. 37(4):893-905 . PubMed
  589. Shi W, et al. 2017. Nat Neurosci. 10.1038/nn.4519. PubMed
  590. Brann DH, et al. 2020. Sci Adv. 6:00. PubMed
  591. McNeely KC, et al. 2020. Proc Natl Acad Sci U S A. 117:9584. PubMed
  592. Li Y, et al. 2021. Stem Cell Research. 55:102460. PubMed
  593. Hilla AM, et al. 2018. BIO-PROTOCOL. 8(16):e2979. PubMed
  594. Kitajima R, et al. 2020. Stem Cell Res. 101749:44. PubMed
  595. Fouda AY, et al. 2020. Invest Ophthalmol Vis Sci. 51:61. PubMed
  596. Wu X, et al. 2018. Cell. 172:423. PubMed
  597. Buijsen RAM et al. 2018. Stem cell research. 29:125-128 . PubMed
  598. Miquel‐Serra L et al. 2018. Stem cell research. 24:155-159 . PubMed
  599. Senft AD, et al. 2018. Cell Rep. 24:1977. PubMed
  600. Gao L, et al. 2019. Sci Rep. 9:3462. PubMed
  601. Xu Z, et al. 2018. Development. 145:. PubMed
  602. Christiansen EM, et al. 2018. Cell. 173:792. PubMed
  603. Rich CA, et al. 2018. Glia. 66:2617. PubMed
  604. Heil C, et al. 2019. Open Biol. 9:180145. PubMed
  605. Wanner R, et al. 2019. Front Neurol. 10:310. PubMed
  606. Hickey SL et al. 2019. Cell reports. 27(6):1699-1711 . PubMed
  607. Suarato G, et al. 2017. Biomaterials. 112:176. PubMed
  608. Watanabe Y, et al. 2018. Development. 145. PubMed
  609. Chanda S et al. 2019. Cell Stem Cell. 25(1):103-119 . PubMed
  610. Wu Z, et al. 2019. Neuron. 101:635. PubMed
  611. Bachmann SB, et al. 2019. Cell Rep. 27:3305. PubMed
  612. Kaplan A, et al. 2017. Neuron. 93:1082. PubMed
  613. Tozer S, et al. 2017. Neuron. 93:542. PubMed
  614. Leibinger M et al. 2017. Proceedings of the National Academy of Sciences of the United States of America. 114(27):E5454-E5463 . PubMed
  615. Syc–Mazurek SB, et al. 2018. Cell Death Dis. 1.135416667. PubMed
  616. Kang PH, et al. 2020. Mol Biol Cell. 31:386. PubMed
  617. Tehrani S, et al. 2018. Sci Rep. 8:4453. PubMed
  618. Russo R, et al. 2018. Cell Death Dis. 1.05625. PubMed
  619. Suenkel C, et al. 2020. Cell Reports. 30(7):2170-2179. PubMed
  620. Peitz M, et al. 2020. STAR Protoc. 1:100038. PubMed
  621. Petrovic A, et al. 2021. Front Cell Neurosci. 15:661492. PubMed
  622. Liang D, et al. 2021. Nat Neurosci. 24:941. PubMed
  623. Lautz JD, et al. 2021. Cell Rep. 37:110076. PubMed
  624. De La Rossa A, et al. 2022. Elife. 11:. PubMed
  625. Rabadán MA, et al. 2022. Nat Commun. 13:3340. PubMed
  626. Williams LA, et al. 2022. Mol Ther Nucleic Acids. 29:189. PubMed
  627. Vahsen BF, et al. 2022. Sci Rep. 12:12606. PubMed
  628. Sefiani A, et al. 2022. Sci Rep. 12:13125. PubMed
  629. Tay SH, et al. 2021. Methods Mol Biol. 2549:359. PubMed
  630. Fisher ES, et al. 2022. J Neuroinflammation. 19:266. PubMed
  631. Calado SM, et al. 2021. Stem Cell Research. 55:102462. PubMed
  632. Bieler M, et al. 2021. Journal of Comparative Neurology. 529(12):3194-3205. PubMed
  633. Kondo N, et al. 2020. Cancers (Basel). 12:00. PubMed
  634. Friocourt F, et al. 2017. Sci Rep. 7:37569. PubMed
  635. Fimiani C, et al. 2016. Sci Rep. 6:39311. PubMed
  636. Damiani D, et al. 2016. Nat Commun. 7:13509. PubMed
  637. Hegazy A, et al. 2016. J Biol Chem. 291: 21496 - 21509. PubMed
  638. Maison S, Liberman L, Liverman M 2016. eNeuro. 3: ENEURO.0207-16.2016. PubMed
  639. Edmondson R, Adock A, Yang L 2016. PLoS One. 11: 0158116. PubMed
  640. Jablonski K, et al. 2016. Stem Cell Reports. 8: 1119-1127. PubMed
  641. Rraklli V, et al. 2016. Stem Cell Res. 16:1-9. PubMed
  642. Kizuka Y, et al. 2016. Biochem J. 473: 21 - 30. PubMed
  643. Kim K, et al. 2013. J Cell Biol. 200:443-458. PubMed
  644. Cesca F, et al. 2012. Cell Death Differ. 19:194-208. PubMed
  645. Yao H, et al. 2020. Sci Rep. 10:17445. PubMed
  646. Matthies D, et al. 2020. Sci Rep. 10:11953. PubMed
  647. Hattori Y, et al. 2020. Nat Commun. 11:1631. PubMed
  648. Duncan DS, et al. 2018. Front Neurosci. 0.9875. PubMed
  649. Welsbie DS et al. 2017. Neuron. 94(6):1142-1154 . PubMed
  650. Belle M et al. 2017. Cell. 169(1):161-173 . PubMed
  651. Walker LJ et al. 2017. eLife. 6 pii: e22540. PubMed
  652. Mura M et al. 2019. Stem Cell Res. 1727:31:00 . PubMed
  653. Gao F et al. 2019. Mol Cell. 75(5):891-904 . PubMed
  654. Kurabayashi N, et al. 2018. Development. 145. PubMed
  655. Miesfeld JB et al. 2017. Gene expression patterns : GEP. 27:114-121 . PubMed
  656. Calatayud C, et al. 2019. Sci Rep. 9:6811. PubMed
  657. Pai EL et al. 2019. Cell reports. 26(5):1157-1173 . PubMed
  658. Teng X, et al. 2018. Thyroid. 28:667. PubMed
  659. Sun L, et al. 2017. Oncotarget. 8:40065. PubMed
  660. Spitalieri P, et al. 2018. Front Physiol. 9:967. PubMed
  661. Erin Frey et al. 2018. eNeuro. 5(3) pii: ENEURO. PubMed
  662. Mura M et al. 2018. Stem cell research. 29:157-161 . PubMed
  663. Rantanen LM, et al. 2022. Cells. 11:. PubMed
  664. Hamity MV, et al. 2022. Invest Ophthalmol Vis Sci. 63:38. PubMed
  665. Lam AN, et al. 2021. Data Brief. 35:106897. PubMed
  666. Cui K, et al. 2022. Cell Regen. 11:7. PubMed
  667. Zhao D, et al. 2021. Cell Death Differ. 28:337. PubMed
  668. Schenk MS, et al. 2021. Transl Vis Sci Technol. 10:22. PubMed
  669. Dong Y, et al. 2021. STAR Protoc. 2:100853. PubMed
  670. Flores-Otero J, et al. 2007. J Neurosci. 27:14023-14034. PubMed
  671. Wang L, Hou S, Han Y 2016. Nat Neurosci. 19: 888-896. PubMed
  672. Roese-Koerner B, et al. 2016. Stem Cell Reports. 7:207-219. PubMed
  673. Choi R, et al. 2020. Laryngoscope Investig Otolaryngol. 0.885416667. PubMed
  674. Ng AQE, et al. 2020. Cell Reports. 30(5):1434-1446.e7. PubMed
  675. Hawkins FJ, et al. 2020. Cell Stem Cell. 28(1):79-95.e8. PubMed
  676. Arber C, et al. 2021. Cell Reports. 34(2):108615. PubMed
  677. Zhang X, et al. 2021. Cell Reports. 34(11):108830. PubMed
  678. Czeisler C, et al. 2016. Journal of Comparative Neurology. 524(17):3485-3502. PubMed
  679. Abreu CA, et al. 2021. Journal of Neurochemistry. 158(3):694-709. PubMed
  680. Liu P, et al. 2017. Stem Cell Rep. 10.1016/j.stemcr.2017.05.007. PubMed
  681. Sommer A et al. 2018. Cell stem cell. 23(1):123-131 . PubMed
  682. Mains RE et al. 2018. Endocrinology. 159(7):2621-2639 . PubMed
  683. Kelly SM et al. 2018. Neuron. 99(2):345-361 . PubMed
  684. Han S, et al. 2018. Development. 145:. PubMed
  685. Friedl RM, et al. 2019. Dis Model Mech. 0.5. PubMed
  686. Khayati K, et al. 2017. FASEB J. 31:598. PubMed
  687. Comai G et al. 2019. Elife. 8 pii: e47460. PubMed
  688. Lee SG et al. 2018. Stem Cell Res. 31:197-200 . PubMed
  689. Zhu J et al. 2017. Cell stem cell. 20(3):374-384 . PubMed
  690. Gouti M, et al. 2017. Dev Cell. 41:243. PubMed
  691. Levin E et al. 2017. Scientific reports. 7(1):643 . PubMed
  692. Tokuyama MA, et al. 2018. Dev Biol. 433:287. PubMed
  693. Xie Y, et al. 2019. RNA Biol. 0.723611111. PubMed
  694. Yang D, et al. 2019. Elife. 8:e49249. PubMed
  695. Heinrich A, et al. 2020. Cell Rep. 31:107513. PubMed
  696. Park S, et al. 2020. PLoS Biol. 18:e3000296. PubMed
  697. Pappa S, et al. 2019. Proc Natl Acad Sci U S A. 116:19464. PubMed
  698. Marquardt LM, et al. 2020. Sci Adv. 6:eaaz1039. PubMed
  699. Doucet-O'Hare TT, et al. 2021. Sci Rep. 11:12893. PubMed
  700. Gandhi S, et al. 2021. Development. 148:dev193565. PubMed
  701. Ketschek A, et al. 2021. J Neurosci. 41:6637. PubMed
  702. Park SH, et al. 2021. Biochem Pharmacol. 188:114520. PubMed
  703. Oksdath Mansilla M, et al. 2021. BMC Biomed Eng. 3:6. PubMed
  704. Bouma MJ, et al. 2019. Stem Cell Research. 41:101654. PubMed
  705. Rebs S, et al. 2021. Stem Cell Research. 53:102263. PubMed
  706. Gao T, et al. 2021. JCI Insight. 6(10):. PubMed
  707. Liu W, et al. 2020. J Exp Med. 217:00:00. PubMed
  708. Franco A, et al. 2020. Elife. 9:00. PubMed
  709. Chen W, et al. 2017. eNeuro. 3(6). PubMed
  710. Teresa Rivera, Candy Haggblom, Sandro Cosconati 2016. Nat Struct Mol Biol. 24:30-39. PubMed
  711. Jager P, et al. 2016. Nat Commun. 7:13579. PubMed
  712. Zeltner N, et al. 2016. Nat Med. 22:1421-1427. PubMed
  713. Gaitán-Peñas H, et al. 2016. Biophys J. 111:1429-1443. PubMed
  714. Zalfa C, et al. 2016. Cell Death Dis. 7:e2331. PubMed
  715. Li S, et al. 2016. Sci Rep. 6:29514. PubMed
  716. Mita T, et al. 2016. J Biol Chem. 291: 4955 - 4965. PubMed
  717. Jia L, et al. 2018. Mol Neurobiol. 55:9089. PubMed
  718. Sun W, et al. 2020. J Clin Invest. 130:345. PubMed
  719. Baek C, et al. 2018. PLoS Biol. 16:e2004162. PubMed
  720. Miyake S et al. 2015. Cell death & disease. 6:e1638 . PubMed
  721. Wang L et al. 2017. The Journal of comparative neurology. 525(13):2915-2928 . PubMed
  722. Stratton JA et al. 2017. eNeuro. 4(3) pii: ENEURO. PubMed
  723. Norsworthy MW et al. 2017. Neuron. 94(6):1112-1120 . PubMed
  724. Brekk OR et al. 2018. Molecular and cellular neurosciences. 95:1-12 . PubMed
  725. Mura M et al. 2019. Stem cell research. 1726:16:00 . PubMed
  726. Jung JS, et al. 2019. J Neurosci. 39:6425. PubMed
  727. Fan D et al. 2019. Elife. 8 pii: e49226. PubMed
  728. Sarah E Pease‐Raissi et al. 2017. Neuron. 96(2):373-386 . PubMed
  729. Sorrells SF, et al. 2019. Nat Commun. 10:2748. PubMed
  730. Lee J, et al. 2018. Invest Ophthalmol Vis Sci. 59:3531. PubMed
  731. Alexander JM et al. 2019. Elife. 8 pii: e41769. PubMed
  732. Hu D, et al. 2019. Acta Neuropathol. 137:939. PubMed
  733. Acosta S, et al. 2018. Genesis. 56:e23212. PubMed
  734. Stallings NR, et al. 2018. Sci Signal. 11:522. PubMed
  735. Diacou R et al. 2018. Cell reports. 25(9):2510-2523 . PubMed
  736. Liu Y et al. 2018. Cell stem cell. 23(5):758-771 . PubMed
  737. Umegaki Y et al. 2018. The Journal of Neuroscience. 38(21):4985-4995 . PubMed
  738. Urrea L, et al. 2018. Mol Neurobiol. 15:1630. PubMed
  739. Xu X, et al. 2022. Biology (Basel). 11:. PubMed
  740. Namchaiw P, et al. 2022. PLoS One. 17:e0273458. PubMed
  741. Wu C, et al. 2022. J Hum Genet. :. PubMed
  742. Wilmerding A, et al. 2022. Neoplasia. 24:120. PubMed
  743. Yang Y, et al. 2022. Nucleic Acids Res. 50:191. PubMed
  744. Hilton BJ, et al. 2021. Neuron. S0896-6273:00775-3. PubMed
  745. Bassil R, et al. 2021. Nat Commun. 12:5220. PubMed
  746. Vaes N, et al. 2021. EMBO Rep. 22:e51913. PubMed
  747. Dudok J, et al. 2016. Neurosci Res. S0168-0102(16)00002-X. PubMed
  748. Rooney G, et al. 2016. J Neurosci. 36: 142 - 152.. PubMed
  749. Takeo Y, et al. 2016. Sci Rep. 6: 25180. PubMed
  750. Okamoto-Uchida Y, et al. 2016. Sci Rep. 6:37697. PubMed
  751. Wang H, et al. 2017. J Neurochem. 141:347. PubMed
  752. Arber C, et al. 2020. Mol Psychiatry. 25:2919. PubMed
  753. Dementyeva EV, et al. 2021. Stem Cell Research. 53:102348. PubMed
  754. Hung C, et al. 2021. Cell Reports. 35(11):109259. PubMed
  755. Cartoni R, et al. 2016. Neuron. 92(6):1294-1307. PubMed
  756. Schoger E, et al. 2021. Stem Cell Research. 55:102473. PubMed
  757. Valdez C, et al. 2020. Hum Mol Genet. 716:29. PubMed
  758. Tolomeo AM, et al. 2021. Front Cell Neurosci. 602888:15. PubMed
  759. Ornaghi F, et al. 2020. Neurobiol Dis. 134:104667. PubMed
  760. Hackelberg S, et al. 2017. PLoS One. 10.1371/journal.pone.0180427. PubMed
  761. Stepp MA, et al. 2018. Exp Eye Res. 10:113. PubMed
  762. Merten N et al. 2018. Cell chemical biology. 25(6):775-786 . PubMed
  763. Tandon R et al. 2018. Stem cell research. 33:120-124 . PubMed
  764. Kaur T et al. 2018. The Journal of comparative neurology. 526(5):824-835 . PubMed
  765. Lang C et al. 2019. Cell stem cell. 24(1):93-106 . PubMed
  766. Stylianou N, et al. 2019. Oncogene. 38:913. PubMed
  767. Tiihonen J, et al. 2019. Nat Commun. 10:3933. PubMed
  768. Park KK et al. 2017. The Journal of comparative neurology. 525(2):380-388 . PubMed
  769. Chang CH, et al. 2019. Dev Cell. 48:184. PubMed
  770. Hertz NT et al. 2019. Neuron. 103(3):412-422 . PubMed
  771. Angelim MKSC et al. 2018. Glia. 66(11):2470-2486 . PubMed
  772. Wu J et al. 2017. Cell. 168(3):473-486 . PubMed
  773. Ma S et al. 2017. Developmental cell. 41(4):366-381 . PubMed
  774. Sevilla A et al. 2017. Stem Cell Res. 25:217-220 . PubMed
  775. Crouch EE et al. 2015. The Journal of Neuroscience. 35(11):4528-39 . PubMed
  776. Liu Z, et al. 2017. Stem Cells Dev. 26:177. PubMed
  777. Maslon MM, et al. 2019. EMBO J. 38:e101244. PubMed
  778. Steevens AR, et al. 2019. Development. 146:dev170522. PubMed
  779. Liu W, et al. 2019. Invest Ophthalmol Vis Sci. 60:965. PubMed
  780. Lee JH, et al. 2019. Aging (Albany NY). 11:11541. PubMed
  781. Peng XQ, et al. 2020. Front Cell Neurosci. 0.674305556. PubMed
  782. Gangoso E, et al. 2021. Cell. 184:2454. PubMed
  783. Sun Z, et al. 2021. Aging (Albany NY). 13:12587. PubMed
  784. Chen Y, et al. 2021. Nat Methods. 18:528. PubMed
  785. Cast TP, et al. 2021. J Neurosci. 41:392. PubMed
  786. Satoh M, et al. 2021. Int J Mol Sci. 22:. PubMed
  787. Eriksen AZ, et al. 2022. STAR Protoc. 3:101383. PubMed
  788. Kempfle JS, et al. 2021. Front Cell Neurosci. 15:666706. PubMed
  789. Guan Y, et al. 2021. Nat Commun. 12:5078. PubMed
  790. Yao X, et al. 2022. Nat Commun. 13:3883. PubMed
  791. Tasdemir-Yilmaz OE, et al. 2021. Dev Cell. 56:2516. PubMed
  792. Cai T, et al. 2021. Cell Reports. 36(2):109337. PubMed
  793. van Helden RWJ, et al. 2021. Stem Cell Research. 53:102374. PubMed
  794. Calado SM, et al. 2021. Stem Cell Research. 53:102302. PubMed
  795. Sepehrimanesh M, et al. 2020. American Journal of Physiology-Cell Physiology. 319(4):C771-C780. PubMed
  796. Li C, et al. 2020. eLife. 9:00. PubMed
  797. Fame R, et al. 2016. J Neurosci. 36: 6403 - 6419. PubMed
  798. Long K, et al. 2016. Nat Commun. 7:10354. PubMed
  799. Hindman HB, et al. 2019. Exp Eye Res. 181:49. PubMed
  800. Aravamudhan P, et al. 2020. PLoS Pathog. 16:e1008380. PubMed
  801. Medeiros CS, et al. 2018. J Refract Surg. 34:790. PubMed
  802. Romer–Seibert JS, et al. 2019. FASEB J. 33:3291. PubMed
  803. Cotton JL et al. 2017. Developmental cell. 43(1):35-47 . PubMed
  804. Lin B et al. 2017. Cell stem cell. 21(6):761-774 . PubMed
  805. Richard E et al. 2018. Stem cell research. 29:143-147 . PubMed
  806. Kano M, et al. 2019. Endocrinology. 160:1701. PubMed
  807. Schreurs RRCE, et al. 2019. Immunity. 50:462. PubMed
  808. Ioannou MS et al. 2019. Curr Protoc Cell Biol. 84(1):e95 . PubMed
  809. Poulopoulos A, et al. 2019. Nature. 565:356. PubMed
  810. Sun Z, et al. 2019. Nat Commun. 10:3892. PubMed
  811. Ding D, et al. 2018. J Otol. 13:115. PubMed
  812. Fan L et al. 2018. eLife. 7 pii: e35242. PubMed
  813. Amrita Pathak et al. 2018. Developmental cell. 46(3):376-387 . PubMed
  814. Marlier Q et al. 2018. Cell Death Discov. 4:43 . PubMed
  815. Vicentini FA, et al. 2021. Microbiome. 9:210. PubMed
  816. Díaz-García S, et al. 2021. Acta Neuropathol. 142:985. PubMed
  817. Harbuzariu A, et al. 2022. iScience. 25:104407. PubMed
  818. Karpinski BA, et al. 2022. Dis Model Mech. 15:. PubMed
RRID
AB_2313773 (BioLegend Cat. No. 801213)
AB_2313773 (BioLegend Cat. No. 801201)
AB_2313773 (BioLegend Cat. No. 801202)
Disclaimer

Covered by US patents 5,675,063 and 7,429,487. Sold under license from Epitomics.

Antigen Details

Structure
Tubulin β 3 is a 450 amino acid protein with a molecular mass of ~50 kD.
Distribution

Tissue distribution: central and peripheral nervous system.
Cellular distribution: cytosol, cytoskeleton and nucleus.

Function
Tubulin β 3 is the major constituent of microtubules, and plays a critical role in proper axon guidance and maintenance.
Interaction
Alpha tubulin, kinesin and dynein.
Cell Type
Mature Neurons, Neural Stem Cells
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
Microtubules
Antigen References

1. Zhao X, et al. 2017. Med Sci Monit. 22: 3915.
2. Lebok P, et al. 2016. Oncol Lett. 11(3):1987.
3. Du J, et al. 2015. BMC Cancer. 15:536. PubMed
4. Rogue DM., et al. 2013. Clin Exp Metastasis. 31(1): 101.
5. Ploussard G, et al. 2010. Cancer Res. 70(22):9253. PubMed

Gene ID
10381 View all products for this Gene ID
UniProt
View information about Tubulin beta-3 on UniProt.org

Related FAQs

If an antibody clone has been previously successfully used in IBEX in one fluorescent format, will other antibody formats work as well?

It’s likely that other fluorophore conjugates to the same antibody clone will also be compatible with IBEX using the same sample fixation procedure. Ultimately a directly conjugated antibody’s utility in fluorescent imaging and IBEX may be specific to the sample and microscope being used in the experiment. Some antibody clone conjugates may perform better than others due to performance differences in non-specific binding, fluorophore brightness, and other biochemical properties unique to that conjugate.

Will antibodies my lab is already using for fluorescent or chromogenic IHC work in IBEX?

Fundamentally, IBEX as a technique that works much in the same way as single antibody panels or single marker IF/IHC. If you’re already successfully using an antibody clone on a sample of interest, it is likely that clone will have utility in IBEX. It is expected some optimization and testing of different antibody fluorophore conjugates will be required to find a suitable format; however, legacy microscopy techniques like chromogenic IHC on fixed or frozen tissue is an excellent place to start looking for useful antibodies.

Are other fluorophores compatible with IBEX?

Over 18 fluorescent formats have been screened for use in IBEX, however, it is likely that other fluorophores are able to be rapidly bleached in IBEX. If a fluorophore format is already suitable for your imaging platform it can be tested for compatibility in IBEX.

The same antibody works in one tissue type but not another. What is happening?

Differences in tissue properties may impact both the ability of an antibody to bind its target specifically and impact the ability of a specific fluorophore conjugate to overcome the background fluorescent signal in a given tissue. Secondary stains, as well as testing multiple fluorescent conjugates of the same clone, may help to troubleshoot challenging targets or tissues. Using a reference control tissue may also give confidence in the specificity of your staining.

How can I be sure the staining I’m seeing in my tissue is real?

In general, best practices for validating an antibody in traditional chromogenic or fluorescent IHC are applicable to IBEX. Please reference the Nature Methods review on antibody based multiplexed imaging for resources on validating antibodies for IBEX.

Go To Top Version: 7    Revision Date: 01/24/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere

Login / Register
Remember me
Forgot your password? Reset password?
Create an Account