- Clone
- W16216D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Poliovirus receptor-related immunoglobulin domain containing protein, PVRIG, C7orf15, CD112 receptor
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![W16216D_PURE_CD112R_Antibody_050520 W16216D_PURE_CD112R_Antibody_050520](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/W16216D_PURE_CD112R_Antibody_050520.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Jurkat cells were infected with control shRNA (open purple histograms) or CD112R-specific shRNA (filled purple histogram) letiviral particles. These cells were stained with purified CD112R (PVRIG) (clone W16216D); the control shRNA lentivirus infected cells were also stainined with purified rat IgG2a, κ isotype control (black dashed open histogram). The binding of antibodies was detected by goat anti-rat IgG APC.
Cat # | Size | Price | Quantity Check Availability | Save | ||
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301502 | 100 µg | 264€ |
CD112R gene encodes a single transmembrane protein consisting of a single extracellular IgV domain. Its long intracellular domain contains two tyrosine residues, one of which is within an ITIM-like motif. CD112R was initially named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes. CD112R is a cell surface receptor for CD112/Nectin-2, it compete against CD226 in binding to CD112. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response. Published studies suggest that CD112R is a novel co-inhibitory receptor, or a checkpoint molecule, that suppressed TCR medicated signal.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Human CD112R transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2860764 (BioLegend Cat. No. 301502)
Antigen Details
- Structure
- IgV domain; ITIM motif
- Distribution
-
T cells, NK cells
- Function
- Cell surface receptor for CD112, negative regulator of T cell response
- Ligand/Receptor
- CD112 (Nectin-2)
- Cell Type
- Leukocytes, Lymphocytes, NK cells, T cells
- Biology Area
- Adaptive Immunity, Immuno-Oncology, Immunology, Inhibitory Molecules
- Molecular Family
- Immune Checkpoint Receptors
- Antigen References
-
- Xu F, et al. 2017. Cancer Immunol. Immunother. 66:1367-1375.
- Zhu Y, et al. 2016. J. Exp. Med. 213(2):167-76.
- Gene ID
- 79037 View all products for this Gene ID
- UniProt
- View information about CD112R on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All CD112R Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
APC anti-human CD112R (PVRIG) | W16216D | FC |
Purified anti-human CD112R (PVRIG) | W16216D | FC |
PE anti-human CD112R (PVRIG) | W16216D | FC |
TotalSeq™-B1454 anti-human CD112R (PVRIG) | W16216D | PG |
TotalSeq™-A1454 anti-human CD112R (PVRIG) | W16216D | PG |
TotalSeq™-C1454 anti-human CD112R (PVRIG) | W16216D | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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APC anti-human CD112R (PVRIG)
Jurkat cells were stained with APC anti-human CD112R (clone ... -
Purified anti-human CD112R (PVRIG)
Jurkat cells were infected with control shRNA (open purple h... -
PE anti-human CD112R (PVRIG)
Jurkat cells were stained with PE anti-human CD112R (PVRIG) ... -
TotalSeq™-B1454 anti-human CD112R (PVRIG)
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TotalSeq™-A1454 anti-human CD112R (PVRIG)
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TotalSeq™-C1454 anti-human CD112R (PVRIG)
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