- Clone
- S16018A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD288, Toll-like receptor 8
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![S16018A_Purified_CD288_Antibody_121918_Updated.png S16018A_Purified_CD288_Antibody_121918_Updated.png](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/S16018A_Purified_CD288_Antibody_121918_Updated.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human peripheral blood monocytes were stained with CD14 Pacific Blue™, treated with BioLegend’s Fixation Buffer (Cat. No. 420801) and Permeabilization Wash Buffer (Cat. No. 421002), and then stained with purified CD288 (clone S16018A, left) or purified mouse IgG2a, κ isotype control (right), followed by anti-mouse IgG2a PE.
Cat # | Size | Price | Quantity Check Availability | Save | ||
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395502 | 100 µg | 235€ |
Toll-like receptor (TLR) 8, also known as CD288, is a 83 kDa, type 1 transmembrane protein, member of the TLR receptor family. TLR8 is expressed intracellulary in monocytes, macrophages and myeloid dendritic cells, and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR8 triggers anti-viral reponses promoting the secretion of proinflammatory cytokines such as IL-12 and TNF.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TLR8-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ICFC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
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AB_2783317 (BioLegend Cat. No. 395502)
Antigen Details
- Structure
- 83 kD, Type 1 transmembrane protein
- Distribution
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Endosomal compartments of monocytes, macrophages, myeloid dendritic cells, and neutrophils
- Function
- Binds single-stranded RNA
- Interaction
- MYD88, TRAF6, IRAK4
- Ligand/Receptor
- Single-stranded GU-rich RNA
- Cell Type
- Dendritic cells, Macrophages, Monocytes, Neutrophils
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
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- Lood C, et al. 2017. J Exp Med. 214:2103.
- Prinz N, et al. 2011. Blood. 118:2322.
- Gringhuis SI, et al. 2010. Nat Immunol. 11419.
- Cros J, et al. 2010. Immunity. 33:375.
- Peng G, et al. 2005. Science. 309:1380.
- Gene ID
- 51311 View all products for this Gene ID
- UniProt
- View information about CD288 on UniProt.org
Related FAQs
Other Formats
View All CD288 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD288 (TLR8) | S16018A | ICFC |
PE anti-human CD288 (TLR8) | S16018A | ICFC |
APC anti-human CD288 (TLR8) | S16018A | ICFC |
FITC anti-human CD288 (TLR8) | S16018A | ICFC |
Brilliant Violet 421™ anti-human CD288 (TLR8) | S16018A | ICFC |
PerCP/Cyanine5.5 anti-human CD288 (TLR8) | S16018A | ICFC |
PE/Cyanine7 anti-human CD288 (TLR8) | S16018A | ICFC |
APC/Fire™ 750 anti-human CD288 (TLR8) | S16018A | ICFC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 Paci... -
PE anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 Bril... -
APC anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 Bril... -
FITC anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 APC,... -
Brilliant Violet 421™ anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 APC,... -
PerCP/Cyanine5.5 anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with anti-huma... -
PE/Cyanine7 anti-human CD288 (TLR8)
Human peripheral blood monocytes stained with anti-human CD1... -
APC/Fire™ 750 anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with anti-huma...
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