- Clone
- Michel-19 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- HB15
- Isotype
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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mCD83 transfected cells stained with Michel-19 APC
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
121509 | 25 µg | 100€ | ||||
121510 | 100 µg | 253€ |
CD83 is a 45 kD type I transmembrane protein. It belongs to immunoglobulin superfamily and is expressed on mature dendritic cells and activated lymphocytes. CD83 is involved in the regulation of T cell development and immune response. Soluble form CD83 has been reported to inhibit dendritic cell maturation and dendritic cell-mediated T cell proliferation. Murine CD83 ligand has been found on B cells.
Product DetailsProduct Details
- Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD83 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
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Red Laser (633 nm)
- Application Notes
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Additional reported applications (for relevant formats of this clone) include: immunohistochemistry of acetone - fixed frozen sections4.
- Application References
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- Cramer SO, et al. 2000. Int. Immunol. 12:1347.
- Fujimoto Y, et al. 2002. Cell 108:755.
- Mott KR, et al. 2009. Virol J. 6:56. (FC) PubMed
- Roland Cl, et al. 2009. Mol Cancer Res. 8:1761. (IHC) PubMed
- Masuda Y, et al. 2010. Cancer Immunol Immunother. [Epub ahead of print] (FC) PubMed
- Tze LE, et al. 2011. J Exp Med. PubMed
- del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
- Product Citations
- RRID
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AB_571998 (BioLegend Cat. No. 121509)
AB_571999 (BioLegend Cat. No. 121510)
Antigen Details
- Structure
- Type I transmembrane protein, Ig superfamily, 45kD
- Distribution
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Mature dendritic cells, activated lymphocytes
- Function
- Regulate T cell development and immune response, soluble form CD83 inhibit dendritic cell maturation
- Ligand/Receptor
- CD83 ligand
- Cell Type
- Dendritic cells, Lymphocytes
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
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1. Lechmann M, et al. 2005. Biochem. Biophys. Res. Commun. 329:132.
2. Kotxor N, et al. 2004. Immunobiology 209:129.
3. Leon F, et al. 2004. J. Immunol. 173:2995.
4. Cramer SO, et al. 2000. Int. Immunol. 12:1347.
5. Fujimoto Y, et al. 2002. Cell 108:755. - Gene ID
- 12522 View all products for this Gene ID
- UniProt
- View information about CD83 on UniProt.org
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