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FITC anti-human CD303 (BDCA-2) Antibody

Pricing & Availability
Clone
201A (See other available formats)
Regulatory Status
RUO
Other Names
CLEC4C, CLECSF11, CLECSF7, DLEC, HECL
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
201A_FITC_1_060512
Human peripheral blood mononuclear cells were stained with CD123 APC and CD303 (clone 201A) FITC (top) or mouse IgG2a, κ FITC isotype control (bottom). Data shown was gated on the lymphocyte and monocyte populations.
  • 201A_FITC_1_060512
    Human peripheral blood mononuclear cells were stained with CD123 APC and CD303 (clone 201A) FITC (top) or mouse IgG2a, κ FITC isotype control (bottom). Data shown was gated on the lymphocyte and monocyte populations.
  • 201A_FITC_2_060512
See FITC spectral data
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354207 25 tests 95€
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354208 100 tests 235€
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Description

CD303, also known as BDCA-2 and CLEC4C, is a 38 kD type II transmembrane glycoprotein. It is a member of the C-type lectin superfamily. CD303 is expressed by plasmacytoid dendritic cells (pDCs) and is involved in cell adhesion, signaling, and antigen capture and processing. Crosslinking of CD303 inhibits the production of IFN-α/β and TLR-9 induced pDCs maturation.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application References
  1. Freeman A, et al. 2014. PLoS One. 9:110928. PubMed
  2. Johnson P, et al. 2015. Clin Cnacer Res. 21:1321. PubMed
Product Citations
  1. Hansen IS, et al. 2018. Nat Commun. 9:863. PubMed
  2. Cignarella F et al. 2018. Cell metabolism. 27(6):1222-1235 . PubMed
  3. Adhikaree J, et al. 2019. Oncoimmunology. 8:1593803. PubMed
  4. Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed
  5. Leylek R, et al. 2019. Cell Rep. 29:3736. PubMed
  6. Zhou R, et al. 2020. Immunity. S1074-7613(20)30333-2.. PubMed
  7. Singh A, et al. 2020. Cell Rep. 32:108153. PubMed
  8. Bennstein SB, et al. 2020. eLife. 9:e55232.. PubMed
  9. Lee J, et al. 2015. J Exp Med. 212:385. PubMed
  10. Breton G, et al. 2015. J Exp Med. 212:401. PubMed
  11. Laing AG, et al. 2020. Nat Med. 26:1623. PubMed
  12. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  13. Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed
  14. Golebski K, et al. 2021. Immunity. 54(2):291-307.e7. PubMed
  15. Woo MS, et al. 2021. iScience. 24(7):102752. PubMed
  16. Georgakis S, et al. 2021. JCI Insight. 6:. PubMed
RRID
AB_2561363 (BioLegend Cat. No. 354207)
AB_2561364 (BioLegend Cat. No. 354208)

Antigen Details

Structure
Type II transmembrane protein, 38 kD, member of the C-type lectin superfamily
Distribution

Plasmacytoid dendritic cells

Function
Antigen capture, inhibition of IFN α/β production
Cell Type
Dendritic cells
Biology Area
Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Jähn PS, et al. 2010. Cell Immunol. 265:15.
2. Graham LM and Brown GD. 2009. Cytokine 48:148.
3. Röck J, et al. 2007. Eur. J. Immunol. 37:3564.
4. Dzionek A, et al. 2001. J. Exp. Med. 194:1823.

Gene ID
170482 View all products for this Gene ID
UniProt
View information about CD303 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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