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FITC anti-human CD56 (NCAM) Antibody

Pricing & Availability
Clone
HCD56 (See other available formats)
Regulatory Status
RUO
Other Names
Leu-19, NKH1
Isotype
Mouse IgG1, κ
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Product Citations
publications
HCD56_FITC_070207
Human peripheral blood lymphocytes stained with HCD56 FITC
  • HCD56_FITC_070207
    Human peripheral blood lymphocytes stained with HCD56 FITC
See FITC spectral data
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318303 25 tests 85€
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318304 100 tests 169€
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Description

CD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.

Application References
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
Product Citations
  1. Gorvel L, et al. 2017. J Immunol. 10.4049/jimmunol.1601477. PubMed
  2. Barry KC, et al. 2018. Nat Med. 24:1178. PubMed
  3. Beyer AI, et al. 2017. Stem Cells Dev. 26:102. PubMed
  4. Horn LA, et al. 2017. Oncotarget. 8:57964. PubMed
  5. Motwani MP, et al. 2018. JCI Insight. 3:e94463. PubMed
  6. Bochem J, et al. 2019. PLoS One. 14:e0221301. PubMed
  7. Kim N, et al. 2020. Nat Commun. 2.045138889. PubMed
  8. Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
  9. Agha O, et al. 2020. JOR Spine. 3:e1091. PubMed
  10. Hagan T, et al. 2020. Cell. 178(6):1313-1328.e13.. PubMed
  11. Zhu Y, et al. 2019. Cell Stem Cell. 25:542. PubMed
  12. Brown CC, et al. 2020. Cell. 179(4):846-863.e24.. PubMed
  13. Huang Y, et al. 2008. J Immunol. 180:2367. PubMed
  14. Nakajima K, et al. 2011. J Immunol. 186:4481. PubMed
  15. Palamides P, et al. 2016. Dis Model Mech. 9: 985 - 997. PubMed
  16. Fisher J, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.03.002. PubMed
  17. Kwok I, et al. 2020. Immunity. 53(2):303-318.e5. PubMed
  18. Wang F, et al. 2021. Cell. 184(2):422-440.e17. PubMed
  19. Sutton HJ, et al. 2021. Cell Reports. 34(6):108684. PubMed
  20. Kobayashi Y, et al. 2020. Int J Oncol. 999:56. PubMed
  21. Xu P, et al. 2020. Cancer Immunol Res. 8:1193. PubMed
  22. Sweeney EE, et al. 2020. Nano Res. 13:736. PubMed
  23. Ruth JH, et al. 2021. JCI Insight. 6:e145662. PubMed
  24. Kim ST, et al. 2021. J Immunother Cancer. 9:. PubMed
  25. Nakano M, et al. 2021. Front Immunol. 12:713225. PubMed
  26. Carre C, et al. 2021. iScience. 24:102970. PubMed
  27. Devalraju KP, et al. 2021. PLoS One. 16:e0257185. PubMed
  28. Li YR, et al. 2021. Cell Rep Med. 2:100449. PubMed
  29. Kim MY, et al. 2021. JCI Insight. 6:. PubMed
  30. Ceglia V, et al. 2022. Front Immunol. 12:786144. PubMed
  31. Zhang X, et al. 2021. Front Immunol. 12:602492. PubMed
  32. Cai D, et al. 2021. Front Mol Biosci. 8:686803. PubMed
  33. Hess NJ, et al. 2020. J Immunol. 205:272. PubMed
  34. Wang SQ, et al. 2021. J Viral Hepat. 28:795. PubMed
  35. Pappa V, et al. 2021. J Neuroimmunol. 353:577524. PubMed
  36. Weiss R, et al. 2021. Cells. 10:. PubMed
  37. Kim ST, et al. 2022. Nat Commun. 13:1970. PubMed
  38. Bradley D, et al. 2022. Nat Commun. 13:5606. PubMed
  39. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  40. Yuan H, et al. 2022. J Clin Exp Hematop. 62:52. PubMed
  41. Dorna J, et al. 2022. Front Immunol. 13:827760. PubMed
  42. Korniotis S, et al. 2022. J Cell Sci. 135:. PubMed
  43. Porbahaie M, et al. 2023. PLoS One. 18:e0279626. PubMed
  44. Freund EC, et al. 2023. Methods Mol Biol. 2618:201. PubMed
RRID
AB_604091 (BioLegend Cat. No. 318303)
AB_604100 (BioLegend Cat. No. 318304)

Antigen Details

Structure
Ig superfamily, single transmembrane or GPI-anchored glycoprotein
Distribution

NK cells, T subset, neural tissue, some LGL and myeloid leukemias

Function
Adhesion
Ligand/Receptor
Heparin sulfate
Cell Type
B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Lanier L, et al. 1991. J. Immunol. 146:4421.
2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71.
3. Cremer H, et al. 1994. Nature 367:455.

Gene ID
4684 View all products for this Gene ID
UniProt
View information about CD56 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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