- mCD30.1 (See other available formats)
- Other Names
- Ber-H2, Ki-1, TNFRSF8
- Armenian Hamster IgG
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- Product Citations
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CD30 is a 105 kD type I transmembrane glycoprotein, also known as Ber-H2 or Ki-1. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, expressed on activated T, B, and NK cells, and monocytes. CD28, in conjunction with several cytokines, regulates the expression of CD30 on activated T cells. It has been reported that cytokine production and Th1 versus Th2 development is heavily influenced by CD30-CD30 ligand (CD153) interactions.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- Mouse CD30-mouse IgG1 fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: in vitro induction of IL-5 production1. For the most successful immunofluorescent staining results, it may be necessary to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 102305/102306) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 102304) or biotinylated anti-Armenian hamster IgG (Cat. No. 405501) second step, followed by SAv-PE (Cat. No. 405204)). The LEAF™ purified antibody (Endotoxin <0.1 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 102308).
(PubMed link indicates BioLegend citation)
- Bowen MA, et al. 1996. J. Immunol. 156:442.
- Punt JA, et al. 1997. J. Exp. Med. 186:1911.
- Ye Z, et al. 2010. Mol Immunol. 47:2411. PubMed
- Product Citations
AB_2240925 (BioLegend Cat. No. 102303)
- TNFR superfamily, 105-120 kD
- Activated T cells, B cells and NK cells, monocytes
- Costimulation, regulates negative selection of thymocytes
- CD153 (CD30L)
- Cell Type
- T cells, B cells, NK cells, Monocytes, Embryonic Stem Cells, Tregs
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Falini B, et al. 1995. Blood 85:1.
3. Gedrich RW, et al. 1996. J. Biol. Chem. 271:12852.
- Gene ID
- 21941 View all products for this Gene ID
- View information about CD30 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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