- Clone
- 2B10C42 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Mer, Eyk, Nyk, nmf12
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![2B10C42_BV421_MERTK_Antibody_010820.png 2B10C42_BV421_MERTK_Antibody_010820.png](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/2B10C42_BV421_MERTK_Antibody_010820.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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C57BL/6 mouse splenocytes were stained with CX3CR1 APC and MERTK (Mer) (clone 2B10C42) Brilliant Violet 421™ (left) or rat IgG2a, κ Brilliant Violet 421™ isotype control (right).
Cat # | Size | Price | Quantity Check Availability | Save | ||
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151510 | 50 µg | $292 |
MerTK (Mer) is a member of the TAM (TYRO3/AXL/MerTK) family. It is a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. MerTK is mainly expressed by macrophages, monocytes, and dendritic cells. Its ligands are LGALS3, TUB, TULP1, and GAS6. MerTK is involved in the regulation of TLR signaling, efferocytosis, phagocytosis, cell survival, macrophage migration, and the inhibition of inflammation.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse MERTK extracellular domain
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
-
Violet Laser (405 nm)
- Product Citations
-
- RRID
-
AB_2832533 (BioLegend Cat. No. 151510)
Antigen Details
- Structure
- Member of the TAM (TYRO3/AXL/MerTK) family. Encodes a transmembrane protein, two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain.
- Distribution
-
Macrophages, monocytes, and dendritic cells.
- Function
- Regulates TLR signaling, efferocytosis, phagocytosis, cell survival, and macrophage migration. Inhibits production of inflammatory cytokines.
- Interaction
- Grb2, LimD4, and Vav1.
- Ligand/Receptor
- LGALS3, TUB, TULP1, and GAS6.
- Cell Type
- Dendritic cells, Macrophages, Monocytes
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Toll Like Receptors
- Antigen References
-
1. Zagórska A, et al. 2014. Nat. Immunol. 15:920.
2. Toda S, et al. 2014. Blood 123:3963.
3. Chung WS, et al. 2013. Nature 504:394.
4. Carrera Silva EA, et al. 2013. Immunity 39:160.
5. Yi Z, et al. 2009. Blood 114:3191. - Gene ID
- 17289 View all products for this Gene ID
- UniProt
- View information about MERTK on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- What is the F/P ratio range of our BV421™ format antibody reagents?
-
It is lot-specific. On average it ranges between 2-4.
Other Formats
View All MERTK (Mer) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse MERTK (Mer) | 2B10C42 | FC |
PE anti-mouse MERTK (Mer) | 2B10C42 | FC |
FITC anti-mouse MERTK (Mer) | 2B10C42 | FC |
APC anti-mouse MERTK (Mer) | 2B10C42 | FC |
Brilliant Violet 421™ anti-mouse MERTK (Mer) | 2B10C42 | FC |
TotalSeq™-C0565 anti-mouse MERTK (Mer) | 2B10C42 | PG |
APC/Cyanine7 anti-mouse MERTK (Mer) | 2B10C42 | FC |
PE/Cyanine7 anti-mouse MERTK (Mer) | 2B10C42 | FC |
PE/Dazzle™ 594 anti-mouse MERTK (Mer) | 2B10C42 | FC |
Brilliant Violet 711™ anti-mouse MERTK (Mer) | 2B10C42 | FC |
Brilliant Violet 605™ anti-mouse MERTK (Mer) | 2B10C42 | FC |
TotalSeq™-B0565 anti-mouse MERTK (Mer) | 2B10C42 | PG |
KIRAVIA Blue 520™ anti-mouse MERTK (Mer) Antibody | 2B10C42 | FC |
TotalSeq™-A0565 anti-mouse MERTK (Mer) | 2B10C42 | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse MERTK (Mer)
Microglial cells from an adult mouse were enriched through a... -
PE anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 APC and M... -
FITC anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 APC and M... -
APC anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 PE and ME... -
Brilliant Violet 421™ anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 APC and M... -
TotalSeq™-C0565 anti-mouse MERTK (Mer)
-
APC/Cyanine7 anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 PE and ME... -
PE/Cyanine7 anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 APC and M... -
PE/Dazzle™ 594 anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 APC and M... -
Brilliant Violet 711™ anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 PE and ME... -
Brilliant Violet 605™ anti-mouse MERTK (Mer)
C57BL/6 mouse splenocytes were stained with CX3CR1 PE and ME... -
TotalSeq™-B0565 anti-mouse MERTK (Mer)
-
KIRAVIA Blue 520™ anti-mouse MERTK (Mer) Antibody
C57BL/6 mouse splenocytes were stained with CX3CR1 APC and a... -
TotalSeq™-A0565 anti-mouse MERTK (Mer)
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