- Clone
- S18014C (See other available formats)
- Regulatory Status
- RUO
- Other Names
- 4-1BB, ILA, CDw137, TNFRSF9
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![S18014C_BV-785_CD137_Antibody_101923 S18014C_BV-785_CD137_Antibody_101923](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/S18014C_BV-785_CD137_Antibody_101923-.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
-
PHA-stimulated (3 days) human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD137 (4-1BB) (clone S18014C) Brilliant Violet 785™ (left) or mouse IgG1, κ Brilliant Violet 785™ isotype control (right).
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
300817 | 25 tests | $215 | ||||
300818 | 100 tests | $435 |
CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CD137-Fc
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 785™ under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 785™ excites at 405 nm and emits at 785 nm. The bandpass filter 780/60 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 785™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
-
Violet Laser (405 nm)
- RRID
-
AB_3097264 (BioLegend Cat. No. 300817)
AB_3097264 (BioLegend Cat. No. 300818)
Antigen Details
- Structure
- TNFR superfamily, type I transmembrane protein, 30 kD
- Distribution
-
Activated T cells
- Function
- T cell costimulation
- Ligand/Receptor
- 4-1BB ligand (CD137L)
- Cell Type
- Lymphocytes, NK cells, NKT cells, T cells
- Biology Area
- Costimulatory Molecules, Immuno-Oncology, Immunology, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
-
- Gruss HJ & Dower SK. 1995. Blood. 85:3378-404.
- Sica G & Chen L. 2000. Adv Exp Med Biol. 465:355-62.
- Alderson MR, et al. 1994. Eur J Immunol. 24:2219-27.
- Schwarz H, et al. 1996. Blood 87:2839-45.
- Gene ID
- 3604 View all products for this Gene ID
- UniProt
- View information about CD137 on UniProt.org
Related FAQs
Other Formats
View All CD137 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE anti-human CD137 (4-1BB) | S18014C | FC |
Purified anti-human CD137 (4-1BB) Antibody | S18014C | FC |
Spark Red™ 718 anti-human CD137 (4-1BB) | S18014C | FC |
KIRAVIA Blue 520™ anti-human CD137 (4-1BB) | S18014C | FC |
APC anti-human CD137 (4-1BB) | S18014C | FC |
PE/Dazzle™ 594 anti-human CD137 (4-1BB) | S18014C | FC |
APC/Fire™ 750 anti-human CD137 (4-1BB) | S18014C | FC |
PE/Cyanine7 anti-human CD137 (4-1BB) | S18014C | FC |
Brilliant Violet 785™ anti-human CD137 (4-1BB) | S18014C | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE anti-human CD137 (4-1BB)
PHA-stimulated (3 days) human peripheral blood lymphocytes w... -
Purified anti-human CD137 (4-1BB) Antibody
PHA-stimulated (3 days) human peripheral blood mononuclear c... -
Spark Red™ 718 anti-human CD137 (4-1BB)
PHA-stimulated (3 days) human peripheral blood lymphocytes w... -
KIRAVIA Blue 520™ anti-human CD137 (4-1BB)
PHA-activated human peripheral blood lymphocytes were staine... -
APC anti-human CD137 (4-1BB)
PHA-stimulated (3 days) human peripheral blood lymphocytes w... -
PE/Dazzle™ 594 anti-human CD137 (4-1BB)
PHA-stimulated (3 days) human peripheral blood lymphocytes w... -
APC/Fire™ 750 anti-human CD137 (4-1BB)
PHA-stimulated (3 days) human peripheral blood lymphocytes w... -
PE/Cyanine7 anti-human CD137 (4-1BB)
PHA-stimulated (3 days) human peripheral blood lymphocytes w... -
Brilliant Violet 785™ anti-human CD137 (4-1BB)
PHA-stimulated (3 days) human peripheral blood lymphocytes w...
Follow Us