- 14.27 (See other available formats)
- Other Names
- T10 , ADP-ribosyl cyclase
- Mouse IgG2b, κ
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- Product Citations
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CD38 is a 45 kD type II transmembrane ADP-ribosyl cyclase expressed on early hematopoietic precursors and leukocytes, hepatic stellate cells, astrocytes and epithelial cells. CD38 expression can be upregulated upon cell activation. CD38 catalyzes the production of cyclic APD ribose, which is important in Ca2+ release. CD38 induces production of proinflammatory cytokines and proliferation. The ligand for CD38 is CD31. Impairment in CD38 expression is associated with immunological and behavioral disorders.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemistry1 and Western blotting1.
(PubMed link indicates BioLegend citation)
- March S, et al. 2007. Am. J. Pathol. 170:176. (IHC, WB)
AB_2563068 (BioLegend Cat. No. 250503)
- CD38 is a 45 kD type II transmembrane protein.
Early hematopoietic precursors and leukocytes, astrocytes, hepatic stellate cells, and epithelial cells; upregulated upon activation.
- CD38 catalyzes the production of cyclic APD ribose, which is important in Ca2+ release. CD38 induces production of proinflammatory cytokines and proliferation.
- CD31, hyaluronic acid
- Cell Type
- Astrocytes, B cells, Dendritic cells, Epithelial cells, Leukocytes
- Biology Area
- Molecular Family
- Adhesion Molecules, MHC Antigens
- Antigen References
1. Ota H, et al. 2012. Life Sci. 90:206.
2. Masuda W, et al. 2011. Arch. Biochem. Biophys. 2:131.
3. Khoo KM, et al. 1998. Biochem. Mol. Biol. Int. 44:841.
4. Prasad GS, et al. 1996. Nat. Struct. Biol. 3:957.
- Gene ID
- 25668 View all products for this Gene ID
- View information about CD38 on UniProt.org
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