- MJ7/18 (See other available formats)
- Other Names
- Rat IgG2a, κ
- Ave. Rating
- 1 reviews
- Product Citations
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CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.Product Details
- Antibody Type
- Host Species
- Inflamed mouse skin
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F - Validated
WB, IP - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. For immunohistochemical staining on frozen tissue sections, the suggested use of this reagent is 5.0-10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications include: immunoprecipitation, Western blotting, and immunofluorescence histochemistry or immunohistochemistry of acetone-fixed frozen sections2-4.
(PubMed link indicates BioLegend citation)
- Ge AZ and Butcher EC. 1994. Gene 138:201.
- Baluk P, et al. 2003. Am. J. Pathol. 163:1801. (IHC)
- Takahashi T, et al. 2003. Mol. Cell Biol. 23:1817. (IHC)
- Savinov AY, et al. 2003. J. Exp. Med. 197:643. (IHC)
- Product Citations
AB_961066 (BioLegend Cat. No. 120401)
AB_961070 (BioLegend Cat. No. 120402)
- Type I integral membrane protein, homodimer, TGF-β type III receptor family member
Endothelial cells, activated monocytes, macrophages, stromal cells, some cytotrophoblast
- Suppresses TGF-β signaling, angiogenesis
- TGF-β1, TGF-β3
- Cell Type
- Endothelial cells, Macrophages, Mesenchymal Stem Cells, Monocytes
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Immunology, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Gougos A and M. Letarte 1988. J. Immunol. 141:1925.
2. Cheifetz S, et al. 1992. J. Bio. Chem. 267:19027.
3. Barbara NP, et al. 1999. J. Bio. Chem. 274:584.
4. Lastres P, et al. 1992. Eur. J. Immunol. 22:393.
5. Duff S, et al. 2003. FASEB J. 17:984.
6. Warrington K, et al. 2005. Anticancer Res. 25:185.
- Gene ID
- 13805 View all products for this Gene ID
- View information about CD105 on UniProt.org
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