- Clone
- TS2/7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- α1 integrin, VLA-1 α chain, Integrin α1 chain, ITGA1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![TS2slash7_APC_CD49a_Antibody_FC_092815 TS2slash7_APC_CD49a_Antibody_FC_092815](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/TS2slash7_APC_CD49a_Antibody_FC_092815.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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HeLa cells (Human cervical cancer cell lines) were stained with CD49a (clone TS2/7) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
328313 | 25 tests | $119 | ||||
328314 | 100 tests | $261 |
CD49a is a 200 kD type I transmembrane glycoprotein also known as α1 integrin, VLA-1 α chain, or Integrin α1. It associates with CD29 (β1 integrin) to form VLA-1 complex, a collagen IV and alminin-1 receptor. It is expressed on activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells. CD49a is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human CTL line
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
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Red Laser (633 nm)
- Application Notes
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Additional reported applications include: immunoprecipitation1, immunohistochemical staining1 of acetone-fixed frozen tissue sections, and spatial biology (IBEX)3,4.
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Application References
(PubMed link indicates BioLegend citation) - Product Citations
- RRID
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AB_2566377 (BioLegend Cat. No. 328313)
AB_2566378 (BioLegend Cat. No. 328314)
Antigen Details
- Structure
- Integrin alpha chain family, Type I membrane protein, alpha chain of heterodimeric integrin receptor, 200 kD. Associates with CD29 to form VLA-1 complex
- Distribution
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Activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells
- Function
- Adhesion, leukocyte migration
- Ligand/Receptor
- With integrin β1 (CD29) forms receptor for laminin-1 and collagen IV
- Cell Type
- Fibroblasts, Mesenchymal cells, Mesenchymal Stem Cells, Monocytes, NK cells, T cells
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
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- Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiley-Liss Press. p122
- Boiret N, et al. 2005. Exp. Hematol. 33:219
- Gene ID
- 3672 View all products for this Gene ID
- UniProt
- View information about CD49a on UniProt.org
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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