- Clone
- NC-08 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T1a, T1a2, gp36, gp38, gp40, Aggrus, PDPN, D2-40
- Isotype
- Rat IgG2a, λ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![NC-08_FITC_Podoplanin_Antibody_081318 NC-08_FITC_Podoplanin_Antibody_081318](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/NC-08_FITC_Podoplanin_Antibody_081318.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human glioblastoma cell line LN319 was stained with podoplanin (clone NC-08) FITC (filled histogram) or Rat IgG2a, λ FITC isotype control (open histogram).
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
337025 | 25 tests | $101 | ||||
337026 | 100 tests | $229 |
Podoplanin is a 40-43 kD type-I transmembrane sialomucin-type glycoprotein, also known as T1a, gp36, gp38, gp40, and Aggrus. Originally detected on the surface of podocytes, futher characterization showed podoplanin has a broad tissue distribution, including mesothelial cells, epithelial cells, follicular dendritic cells, and a variety of tumor cells. It has been reported that podoplanin is the ligand of CLEC2 and is involved in lymphatic vessel formation, platelet aggregation, and tumor metastasis. Podoplanin may serve as a useful marker for tumor diagnosis and prognosis.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Blue Laser (488 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: immunofluorescence1.
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Application References
(PubMed link indicates BioLegend citation) -
- Fujino N, et al. 2012. Am. J. Respir. Cell. Mol. Biol. 46:422. (FC, IF)
- Product Citations
- RRID
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AB_2750285 (BioLegend Cat. No. 337025)
AB_2750286 (BioLegend Cat. No. 337026)
Antigen Details
- Structure
- 40-43 kD type-I transmembrane sialomucin-type glycoprotein
- Distribution
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Broad tissue distribution, including mesothelial cells, epithelial cells, follicular dendritic cells, and many tumor cells
- Function
- Lymphatic vessel formation, tumor metastasis, platelet aggregation
- Ligand/Receptor
- CLEC2
- Cell Type
- Dendritic cells
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Antigen References
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1. Raica M, et al. 2008. Anticancer Res. 28:2997.
2. Xie Q, et al. 2008. Int. J. Clin. Exp. Pathol. 1:276.
3. Ogasawara S, et al. 2008. Hybridoma. 27:259.
4. Kato Y, et al. 2003. J. Bio. Chem. 278:51599. - Gene ID
- 10630 View all products for this Gene ID
- UniProt
- View information about Podoplanin on UniProt.org
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