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PE/Cyanine7 anti-mouse CD38 Antibody

Pricing & Availability
Clone
90 (See other available formats)
Regulatory Status
RUO
Other Names
T10
Isotype
Rat IgG2a, κ
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Product Citations
publications
90_PECy7_011108
C57BL/6 mouse splenocytes stained with 90 PE/Cyanine7
  • 90_PECy7_011108
    C57BL/6 mouse splenocytes stained with 90 PE/Cyanine7
See PE/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
102717 25 µg $106
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102718 100 µg $323
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow pre-B cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Product Citations
  1. Degn SE et al. 2017. Cell. 170(5):913-926 . PubMed
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  13. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
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  15. Shi B, et al. 2018. J Immunol. 200:586. PubMed
  16. Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed
  17. Ly A, et al. 2020. Cell Reports. 29(8):2257-2269.e6.. PubMed
  18. Yu M, et al. 2012. Proc Natl Acad Sci U S A. 109:E879. PubMed
  19. Kaji T, et al. 2012. J Exp Med. 209:2079. PubMed
  20. Kajikawa A, et al. 2015. PLoS One. 10: e0141713. PubMed
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  22. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  23. Ryg-Cornejo V, et al. 2016. Cell Rep. 14:68-81. PubMed
  24. Hilpert C, et al. 2016. J Immunol. 197: 2780 - 2786. PubMed
  25. Huang D, et al. 2020. Nat Commun. 4.520833333. PubMed
  26. Lederer K, et al. 2020. Immunity. 53(6):1281-1295.e5. PubMed
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  28. Haniuda K, et al. 2020. Cell Rep. 33:108333. PubMed
  29. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  30. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  31. Alexandre YO, et al. 2020. Cell Reports. 33(13):108567. PubMed
  32. Sato R, et al. 2020. Int Immunol. 499:32. PubMed
  33. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  34. Jia X, et al. 2021. Clin Transl Immunology. 10:e1336. PubMed
  35. Andersen TK, et al. 2021. Front Immunol. 12:747032. PubMed
  36. Zhang B, et al. 2021. Nature. 599:471. PubMed
  37. Li X, et al. 2021. Front Immunol. 12:779560. PubMed
  38. Juul-Madsen K, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  39. Smith LK, et al. 2021. Elife. 10:. PubMed
  40. Song W, et al. 2022. Immunity. 55:290. PubMed
  41. Duan L, et al. 2021. Immunity. 54:2256. PubMed
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  43. Chen PM, et al. 2022. Sci Adv. 8:eabo4271. PubMed
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  45. Jiang W, et al. 2021. Sci Rep. 11:1864. PubMed
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  49. Shahid AM, et al. 2022. PLoS One. 17:e0278209. PubMed
  50. Voss LF, et al. 2023. Front Immunol. 13:1021370. PubMed
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  53. Zaiken M, et al. 2022. Blood. 139:2983. PubMed
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RRID
AB_2072892 (BioLegend Cat. No. 102717)
AB_2275531 (BioLegend Cat. No. 102718)

Antigen Details

Structure
ADP-ribosyl hydrolase, 42 kD
Distribution

B cells, NK cells, T cell subset, brain, muscle, kidney

Function
Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor
CD31, hyaluronic acid
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Shubinsky G, et al. 1997. Immunity 7:315.
3. Cesano A, et al. 1998. J. Immunol. 160:1106.
4. Cockayne DA, et al. 1998. Blood 92:1324.

Gene ID
12494 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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