- Clone
- LSB2.20 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- SIRPgamma, Signal regulatory protein β2 (SIRPβ2)
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![LSB2dot20_Pure_102108.jpg LSB2dot20_Pure_102108.jpg](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/LSB2dot20_Pure_102108.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human peripheral blood lymphocytes stained with purified LSB2.20, followed by anti-mouse IgG FITC
Cat # | Size | Price | Quantity Check Availability | Save | ||
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336602 | 100 µg | $129 |
Signal Regulatory Proteins (SIRPs) comprise a family of several transmembrane glycoproteins (SIRPα, SIRPβ, and SIRPγ) that belong to immunoglobulin superfamily. SIRPγ is also known as CD172g or SIRPβ2 which is primarily expressed on T cells and a subpopulation of B cells. Like CD172a, the ligand of CD172g is CD47. But the binding affinity with CD172g is lower than CD172a. The biological functions of CD172g include regulation of T-cell transendothelial migration and induction of T cell apoptosis.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
IP - Reported in the literature, not verified in house - Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
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Additional reported applications include: blocks T-cell transendothelial migration
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Application References
(PubMed link indicates BioLegend citation) -
- Stefanidakis M, et al. 2008. Blood 112:1280
- Product Citations
- RRID
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AB_1227768 (BioLegend Cat. No. 336602)
Antigen Details
- Structure
- Transmembrane glycoprotein, Ig superfamily
- Distribution
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T cells, B cell subset
- Function
- Regulate T-cell transendothelial migration, induce T cell apoptosis
- Ligand/Receptor
- CD47
- Cell Type
- B cells, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
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1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers
2. Brooke G, et al. 2004. J. Immunol. 173:2562 - Gene ID
- 55423 View all products for this Gene ID
- UniProt
- View information about CD172g on UniProt.org
Related Pages & Pathways
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