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Purified anti-human CD4 Antibody

Pricing & Availability
Clone
SK3 (See other available formats)
Regulatory Status
RUO
Other Names
T4, Leu3a
Isotype
Mouse IgG1, κ
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Product Citations
publications
SK3_PE_102809
Human peripheral blood lymphocytes stained with SK3, followed by anti-mouse IgG PE.
  • SK3_PE_102809
    Human peripheral blood lymphocytes stained with SK3, followed by anti-mouse IgG PE.
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344602 100 µg $42
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Description

CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Evans RL, et al. 1981. Immunol. 78:544
  2. Arno A et al. 1999. J. Infect. Dis. 180:56
  3. Muech M, et al. 1997. Blood 89:1364
  4. Wang L, et al. 2012. Cytometry A. 81:567. PubMed
Product Citations
  1. Hyun J, et al. 2019. PLoS Pathog. 15:e1007883. PubMed
  2. Ramaglia V et al. 2019. Elife. 8 pii: e48051. PubMed
  3. Del Alcazar D, et al. 2019. Cell Rep. 28:3047. PubMed
  4. Ferdosi SR, et al. 2019. Nat Commun. 1.695833333. PubMed
  5. Chng MHY, et al. 2020. Immunity. 51(6):1119-1135.e5.. PubMed
  6. Abbasi L, et al. 2012. Cytometry A. 81:567. PubMed
  7. Toyoda M, et al. 2015. J Virol. 89: 9639-9652. PubMed
  8. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  9. Rouers A, et al. 2021. Cell Rep Med. 2:100278. PubMed
  10. Song S, et al. 2021. Commun Biol. 4:1338. PubMed
  11. Hsiao F, et al. 2020. PLoS Pathog. 16:e1008450. PubMed
  12. Draganov D, et al. 2021. NPJ Breast Cancer. 7:22. PubMed
  13. Albanese M, et al. 2022. Nat Methods. 19:81. PubMed
  14. Tolbert WD, et al. 2022. Front Immunol. 12:787603. PubMed
  15. Paulikat AD, et al. 2022. J Innate Immun. 14:569. PubMed
  16. Mascarau R, et al. 2023. J Cell Biol. 222:. PubMed
RRID
AB_1937277 (BioLegend Cat. No. 344602)

Antigen Details

Structure
Ig superfamily, type I transmembrane glycoprotein, 55 kD
Distribution

T cell subset, majority of thymocytes, monocytes/macrophages

Function
MHC class II co-receptor, lymphocyte adhesion, thymic differentiation, HIV receptor
Ligand/Receptor
MHC class II molecules, HIV gp120, IL-16
Cell Type
Macrophages, Monocytes, T cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Center D et al. 1996. Immunol. Today 17:476.
2. Gaubin M et al. 1996. Eur. J. Clin. Chem. Clin. Biochem. 34:723.

Gene ID
920 View all products for this Gene ID
UniProt
View information about CD4 on UniProt.org

Related FAQs

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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