- Clone
- 7C9C20 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD204, Macrophage scavenger receptor, MSR, MSR1, SRA
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![7C9C20_APC_CD204_Antibody_021317 7C9C20_APC_CD204_Antibody_021317](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/7C9C20_APC_CD204_Antibody_021317.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human peripheral blood monocytes were stimulated with GM-CSF (6 days), then stained with CD204 (clone 7C9C20) APC (filled histogram) or mouse IgG2a, κ isotype control APC (open histogram).
Cat # | Size | Price | Quantity Check Availability | Save | ||
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371905 | 25 tests | 124€ | ||||
371906 | 100 tests | 280€ |
CD204, also known as scavenger receptor A (SR-A) and the macrophage scavenger receptor (MSR), is one of the phagocytic pattern-recognition receptors (PRRs) expressed on macrophages and dendritic cells. CD204 was initially identified as a receptor mediating recognition and internalization of low-density lipoprotein (LDL) by macrophages and playing critical roles in atherogenesis. CD204 recognizes apoptotic cells, modified lipid proteins, and exogenous pathogen-associated molecular patterns (PAMPs), which results in the induction of innate immune and inflammatory responses. CD204 can act as a co-receptor for Toll-like receptors, such as TLR3, TLR4, or TLR9, to facilitate the expression of proinflammatory cytokines. CD204 has been implicated in several pathological processes such as Alzheimer’s disease, sepsis, ischemic injury, and coronary artery disease.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant extracellular domain of human CD204.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
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Red Laser (633 nm)
- Product Citations
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- RRID
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AB_2650769 (BioLegend Cat. No. 371905)
AB_2650770 (BioLegend Cat. No. 371906)
Antigen Details
- Structure
- Type II transmembraine protein, trimer, member of the scavenger receptor familly.
- Distribution
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Macrophages, dendritic cells, strong expression in microglia during Alzheimer's disease.
- Function
- Uptake of negatively charged molecules.
- Antigen References
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1. Kelley JL, et al. 2014. Crit. Rev. Immunol. 34:241.
2. Chen Y, et al. 2011. Blood. 118:390.
3. Yu X, et al. 2011. J. Biol. Chem. 286:18795.
4. Limmon GV, et al. 2008. FASEB J. 22:159. - Gene ID
- 4481 View all products for this Gene ID
- UniProt
- View information about CD204 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CD204 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD204 | 7C9C20 | FC |
PE anti-human CD204 | 7C9C20 | FC |
APC anti-human CD204 | 7C9C20 | FC |
PE/Cyanine7 anti-human CD204 | 7C9C20 | FC |
TotalSeq™-A0399 anti-human CD204 | 7C9C20 | PG |
TotalSeq™-B0399 anti-human CD204 | 7C9C20 | PG |
TotalSeq™-C0399 anti-human CD204 | 7C9C20 | PG |
TotalSeq™-D0399 anti-human CD204 | 7C9C20 | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD204
Human peripheral blood monocytes were stimulated 6 days with... -
PE anti-human CD204
Human peripheral blood monocytes were stimulated with GM-CSF... -
APC anti-human CD204
Human peripheral blood monocytes were stimulated with GM-CSF... -
PE/Cyanine7 anti-human CD204
Human peripheral blood monocytes were stimulated with GM-CSF... -
TotalSeq™-A0399 anti-human CD204
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TotalSeq™-B0399 anti-human CD204
-
TotalSeq™-C0399 anti-human CD204
-
TotalSeq™-D0399 anti-human CD204
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