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APC anti-mouse CD8a Antibody

Pricing & Availability
Clone
53-6.7 (See other available formats)
Regulatory Status
RUO
Other Names
T8, Lyt2, Ly-2
Isotype
Rat IgG2a, κ
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Product Citations
publications
53-6dot7_APC_041106
C57BL/6 mouse splenocytes were stained with CD8 (clone 53-6.7) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
  • 53-6dot7_APC_041106
    C57BL/6 mouse splenocytes were stained with CD8 (clone 53-6.7) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
See APC spectral data
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100711 25 µg 27€
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100712 100 µg 84€
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Description

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse thymus or spleen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The CD8a antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone 53-6.7 antibody competes with clone 5H10-1 antibody for binding to thymocytes3. The 53-6.7 antibody has been reported to block antigen presentation via MHC class I and inhibit T cell responses to IL-2. This antibody has also been used for depletion of CD8a+ cells. Additional reported applications (for the relevant formats) include: immunoprecipitation1,3, in vivo and in vitro cell depletion2,10,15, inhibition of CD8 T cell proliferation3, blocking of cytotoxicity3,4, immunohistochemical staining5,6 of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, and spatial biology (IBEX)29,30. Clone 53-6.7 is not recommended for immunohistochemistry of formalin-fixed paraffin sections. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays or in vivo studies (Cat No. 100746).

Application References
  1. Ledbetter JA, et al. 1979. Immunol. Rev. 47:63. (IHC, IP)
  2. Hathcock KS. 1991. Current Protocols in Immunology. 3.4.1. (Deplete)
  3. Takahashi K, et al. 1992. P. Natl. Acad. Sci. USA 89:5557. (Block, IP)
  4. Ledbetter JA, et al. 1981. J. Exp. Med. 153:1503. (Block)
  5. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  6. Fan WY, et al. 2001. Exp. Biol. Med. 226:1045. (IHC)
  7. Shih FF, et al. 2006. J. Immunol. 176:3438. (FC)
  8. Kamimura D, et al. 2006. J. Immunol. 177:306.
  9. Bouwer HGA, et al. 2006. P. Natl. Acad. Sci. USA 103:5102. (FC, Deplete)
  10. Kao C, et al. 2005. Int. Immunol. 17:1607. PubMed
  11. Ko SY, et al. 2005. J. Immunol. 175:3309. (FC) PubMed
  12. Rasmussen JW, et al. 2006. Infect. Immun. 74:6590. PubMed
  13. Lee CH, et al. 2009. Clin. Cancer Res. PubMed
  14. Geiben-Lynn R, et al. 2008. Blood 112:4585. (Deplete) PubMed
  15. Kingeter LM, et al. 2008. J. Immunol. 181:6244. PubMed
  16. Guo Y, et al. 2008. Blood 112:480. PubMed
  17. Andrews DM, et al. 2008. J. Virol. 82:4931. PubMed
  18. Britschqui MR, et al. 2008. J. Immunol. 181:7681. PubMed
  19. Kenna TJ, et al. 2008. Blood 111:2091. PubMed
  20. Jordan JM, et al. 2008. Infect. Immun. 76:3717. PubMed
  21. Todd DJ, et al. 2009. J. Exp. Med. 206:2151. PubMed
  22. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  23. Medyouf H, et al. 2010. Blood 115:1175. PubMed
  24. Riedl P, et al. 2009. J. Immunol. 183:370. PubMed
  25. Apte SH, et al. 2010. J. Immunol. 185:998. PubMed
  26. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  27. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  28. Cui L, et al. 2015. J Control Release. 206:220. PubMed
  29. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  30. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Ishidome T et al. 2017. EBioMedicine. 22:89-99 . PubMed
  2. Espinosa-Cueto P, et al. 2017. PLoS One.. 10.1371/journal.pone.0182126. PubMed
  3. Glasner A,et al. 2017. Sci Rep.. 10.1038/s41598-017-12998-w. PubMed
  4. Reismann D, et al. 2017. Nat Commun.. 10.1038/s41467-017-01538-9. PubMed
  5. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  6. Oyarce C, et al. 2018. Front Immunol. 8:1794. PubMed
  7. Solanki A, et al. 2018. Development. 145. PubMed
  8. Divan A, et al. 2018. PLoS One. 13:e0196893. PubMed
  9. Espinosa JR, et al. 2018. Front Immunol. 9:1371. PubMed
  10. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  11. Tippimanchai DD, et al. 2018. Oncoimmunology. 7:e1438105. PubMed
  12. Lee JS et al. 2018. Cell. 174(6):1559-1570 . PubMed
  13. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  14. Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed
  15. Nakamura K, et al. 2018. Cancer Cell. 33:634. PubMed
  16. Johnson JL et al. 2018. Immunity. 48(2):243-257 . PubMed
  17. Logan K Smith et al. 2018. Immunity. 48(2):299-312 . PubMed
  18. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  19. Chen S et al. 2018. Cell reports. 25(7):1729-1740 . PubMed
  20. Wang D, et al. 2018. Immunity. 48:659. PubMed
  21. Ren W, et al. 2018. Mucosal Immunol. 12:531. PubMed
  22. Konishi Y, et al. 2018. iScience. 10:98. PubMed
  23. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  24. Chakrabarti J, et al. 2018. Oncotarget. 9:37439. PubMed
  25. Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
  26. Tran L, et al. 2017. Cancer Immunol Res. 5:1141. PubMed
  27. Koliaraki V et al. 2019. Cell reports. 26(3):536-545 . PubMed
  28. Funk KE, et al. 2019. J Neuroinflammation. 16:22. PubMed
  29. Liu J, et al. 2019. J Exp Med. 216:656. PubMed
  30. Li Y, et al. 2019. Oncol Rep. 41:2679. PubMed
  31. Miska J et al. 2019. Cell reports. 27(1):226-237 . PubMed
  32. Misumi I et al. 2019. Cell Rep. 27(2):514-524 . PubMed
  33. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  34. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  35. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  36. Spangenberg E, et al. 2019. Nat Commun. 10:3758. PubMed
  37. Schuster M, et al. 2017. J Immunol. 199:920. PubMed
  38. Zhang F, et al. 2019. Nat Commun. 10:3974. PubMed
  39. Budida R, et al. 2017. Eur J Immunol. 47:1819. PubMed
  40. Lin YH, et al. 2018. Cancer Immunol Res. 0.25. PubMed
  41. Schuster M, et al. 2019. Front Immunol. 10:1583. PubMed
  42. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  43. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  44. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  45. Takeda Y, et al. 2018. Innate Immun. 24:323. PubMed
  46. Li X, et al. 2017. Front Immunol. 8:1186. PubMed
  47. Liu WL, et al. 2019. Nat Commun. 10:3199. PubMed
  48. Li W, et al. 2019. Nat Commun. 10:3349. PubMed
  49. Liu D et al. 2019. Immunity. 51(1):64-76 . PubMed
  50. Zhang F, et al. 2019. Immunity. 50:738. PubMed
  51. Li X et al. 2019. Immunity. 50(3):576-590 . PubMed
  52. Riffelmacher T et al. 2017. Immunity. 47(3):466-480 . PubMed
  53. Matsuo K, et al. 2018. J Immunol. 200:800. PubMed
  54. Caronni N, et al. 2018. Cancer Res. 78:1685. PubMed
  55. Lee JH, et al. 2018. Transgenic Res. 27:241. PubMed
  56. Al–Zaher AA, et al. 2018. Mol Ther Oncolytics. 0.376388889. PubMed
  57. Zhang J, et al. 2018. Oncoimmunology. 7:e1461301. PubMed
  58. O'Malley G, et al. 2018. Cancer Immunol Res. 1.240277778. PubMed
  59. Leal AS, et al. 2019. Sci Rep. 5.286111111. PubMed
  60. Lin W, et al. 2019. EBioMedicine. 49:133. PubMed
  61. Gupta SS, et al. 2019. Cell Rep. 29:1862. PubMed
  62. Takaku S, et al. 2020. Integr Cancer Ther. 19:1534735419900798. PubMed
  63. Morelli AE, et al. 2020. Cell Rep. 30:3448. PubMed
  64. Ulaganathan VK, et al. 2020. Sci Rep. 10:8453. PubMed
  65. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  66. Han P, et al. 2020. Sci Adv. 6:eaaz1580. PubMed
  67. Soldevilla MM, et al. 2019. Mol Ther. 27:1878. PubMed
  68. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  69. Jiang W, et al. 2017. Sci Rep. 7:6501. PubMed
  70. Kataru RP, et al. 2019. Cancer Immunol Res. 7:1345. PubMed
  71. Xu X, et al. 2020. Chin Med. 15:33. PubMed
  72. Riley JS, et al. 2020. Blood Adv. 4:1102. PubMed
  73. Demircioglu F, et al. 2020. Nat Commun. 11:1290. PubMed
  74. Maluski M, et al. 2019. J Clin Invest. 129:5108. PubMed
  75. Schadt L, et al. 2020. Cell Reports. 29(5):1236-1248.e7.. PubMed
  76. Bai C, et al. 2020. Mol Ther Oncolytics. 17:9. PubMed
  77. Alikhanyan K, et al. 2020. Immun Inflamm Dis. 8:181. PubMed
  78. Wang J, et al. 2020. J Hematol Oncol. 0.610416667. PubMed
  79. Brummer G, et al. 2020. Oncogene. 39:2275. PubMed
  80. Zheng Z, et al. 2020. Cell Death Dis. 0.684722222. PubMed
  81. Horiguchi H, et al. 2019. Genes Dev. 33:1641. PubMed
  82. Zhang NN, et al. 2020. Cell. 182(5):1271-1283. PubMed
  83. Lu Y, et al. 2020. Cell. 180(6):1081-1097. PubMed
  84. Blumenthal D, et al. 2020. eLife. 9:e55995.. PubMed
  85. Chakraborty P, et al. 2020. Cell Reports. 28(7):1879-1893.e7.. PubMed
  86. Zhang C, et al. 2020. Cell Metabolism. 31(1):148-161.e5.. PubMed
  87. Mohamed E, et al. 2020. Immunity. 52(4):668-682.e7.. PubMed
  88. Xu H, et al. 2020. Immunity. 51(4):696-708.e9.. PubMed
  89. Mirando AC, et al. 2020. Oncoimmunology. 9:1760685. PubMed
  90. Medyouf H, et al. 2010. Blood. 115:1175. PubMed
  91. Sun S, et al. 2013. J Immunol. 190:6209. PubMed
  92. Guo H, et al. 2014. J Leukoc Biol. 96:419. PubMed
  93. Tassi I, et al. 2014. J Immunol. 193:4303. PubMed
  94. Gibbins J, et al. 2014. Blood. 124:2953. PubMed
  95. Shade K, et al. 2015. J Exp Med. 212:457. PubMed
  96. Sasaki Y, et al. 2015. PLoS One. 10: 0131176. PubMed
  97. Teo T, et al. 2015. J Virol. 89: 7955-7969. PubMed
  98. Yin Q, et al. 2015. PLoS One. 10: 0137808. PubMed
  99. Ku C, et al. 2015. Genes Dev. 29: 1930-1941. PubMed
  100. Chen S, et al. 2015. Cancer Res . 7: 519-531. PubMed
  101. Poczobutt J, et al. 2016. J Immunol. 196: 891 - 901. PubMed
  102. Cook KD, et al. 2015. Immunity. 43:703-714. PubMed
  103. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  104. Ma Z, et al. 2016. Clin Cancer Res. 22: 2969 - 2980. PubMed
  105. Iwasaki Y, et al. 2016. PLoS One. 11: 0158282. PubMed
  106. Vieyra-Garcia P, et al. 2016. Clin Cancer Res. 22: 3328 - 3339. PubMed
  107. Latasa C, et al. 2016. PLoS One. 11: 0161216. PubMed
  108. Matsumura K, et al. 2016. J Immunol. 197: 3233 - 3244. PubMed
  109. Chen Q, et al. 2016. Nat Commun. 7:13193. PubMed
  110. Vidy A, et al. 2016. PLoS One. 11:e0165361. PubMed
  111. Felker A, Croy B 2016. J Leukoc Biol. 100: 645 - 655. PubMed
  112. Wagner V, et al. 2016. Sci Transl Med. 8: 366ra164. PubMed
  113. Eriksson E, et al. 2016. Gene Ther. 10.1038/gt.2016.80. PubMed
  114. Swanson P, et al. 2016. PLoS Pathog. 12:e1006022. PubMed
  115. Kramer K, et al. 2017. Mol Ther. 25(1):62-70. PubMed
  116. Wu L, et al. 2020. Cell Rep. 33:108327. PubMed
  117. Zheng DW, et al. 2020. Nat Commun. 3.865972222. PubMed
  118. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  119. Choi JG, et al. 2020. Front Immunol. 11:598556. PubMed
  120. Galeano Nio JL, et al. 2020. eLife. 9:00. PubMed
  121. Gong N, et al. 2020. Nat Nanotechnol. 1.35625. PubMed
  122. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  123. Yin X, et al. 2020. Cell Rep. 33:108278. PubMed
  124. Wanner-Seleznik GM, et al. 2020. Immunohorizons. 0.644444444. PubMed
  125. Hoefflin R, et al. 2020. Nat Commun. 3.313194444. PubMed
  126. Yi X, et al. 2020. Sci Adv. 6:eaba3546. PubMed
  127. Ukidve A, et al. 2020. Proc Natl Acad Sci U S A. 117:17727. PubMed
  128. Wang H, et al. 2020. Nat Mater. 1.655555556. PubMed
  129. He C, et al. 2020. Clin Transl Med. 10:e39. PubMed
  130. Bayik D, et al. 2020. Cancer Discov. 1.256944444. PubMed
  131. Elahi S, et al. 2020. Stem Cell Res. 43:101710. PubMed
  132. Aegerter H, et al. 2020. Nat Immunol. 0.975694444. PubMed
  133. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  134. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  135. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  136. Nahrendorf W, et al. 2021. eLife. 10:00. PubMed
  137. Lebratti T, et al. 2021. eLife. 10:00. PubMed
  138. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  139. Alexandre YO, et al. 2020. Cell Reports. 33(13):108567. PubMed
  140. Lu C, et al. 2020. Cancer Cell. 39(1):96-108.e6. PubMed
  141. Shannon JP, et al. 2021. Immunity. 54(2):276-290.e5. PubMed
  142. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  143. Chen R, et al. 2021. Cell Reports. 34(7):108751. PubMed
  144. Zeng W, et al. 2021. STAR Protocols. 2(1):100361. PubMed
  145. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  146. Dallari S, et al. 2021. Cell Host Microbe. 29(6):1014-1029.e8. PubMed
  147. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  148. Uzhachenko RV, et al. 2021. Cell Reports. 35(1):108944. PubMed
  149. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  150. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  151. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  152. Christian LS, et al. 2021. Cell Reports. 35(6):109118. PubMed
  153. Nanou A, et al. 2021. Cell Reports. 35(8):109168. PubMed
  154. Dong L, et al. 2021. Cancer Cell. . PubMed
  155. Hirano KI, et al. 2021. eLife. 0.416666666666667. PubMed
  156. Fu Y, et al. 2020. Mol Ther. 1214:28. PubMed
  157. Pan H, et al. 2020. Mol Psychiatry. . PubMed
  158. Tian T, et al. 2020. Cancer Immunol Res. 660:8. PubMed
  159. Castiello MC, et al. 2020. J Allergy Clin Immunol. . PubMed
  160. Zhan CS, et al. 2020. FASEB J. 14006:34. PubMed
  161. Renrick AN, et al. 2021. Front Immunol. 607044:12. PubMed
  162. Huang Y, et al. 2020. FASEB J. 34:1768. PubMed
  163. Fang W, et al. 2021. J Exp Clin Cancer Res. 40:4. PubMed
  164. Li X, et al. 2021. Cell Death Dis. 12:314. PubMed
  165. Tang-Huau TL, et al. 2021. Viruses. 13: . PubMed
  166. Cong L, et al. 2021. Breast Cancer Res. 23:51. PubMed
  167. Zheng Z, et al. 2021. Biomed Res Int. 2021:5535578. PubMed
  168. Nasarre P, et al. 2021. Cancers (Basel). 13: . PubMed
  169. Kim D, et al. 2021. Nanomicro Lett. 13:31. PubMed
  170. Hu Y, et al. 2021. Cell Death Dis. 12:743. PubMed
  171. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  172. Kiss M, et al. 2020. Cancer Immunol Res. 9:309. PubMed
  173. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  174. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  175. Jiang Y, et al. 2021. Nat Commun. 12:742. PubMed
  176. Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
  177. Robertson TF, et al. 2021. J Cell Biol. 220:. PubMed
  178. Pan Y, et al. 2021. Front Cell Neurosci. 15:664312. PubMed
  179. Zhan Y, et al. 2021. JCI Insight. 6:. PubMed
  180. Jeong SH, et al. 2021. Nat Commun. 12:4405. PubMed
  181. Frazer GL, et al. 2021. J Cell Biol. 220:. PubMed
  182. Bates PD, et al. 2021. Front Immunol. 12:668307. PubMed
  183. Chen G, et al. 2021. Sci Adv. 7:eabg5686. PubMed
  184. Li Y, et al. 2021. Cell Death Dis. 12:1001. PubMed
  185. Li X, et al. 2021. Front Immunol. 12:779560. PubMed
  186. Hewitson JP, et al. 2020. J Immunol. 204:2949. PubMed
  187. Jiang Y, et al. 2020. Adv Mater. 32:e2001808. PubMed
  188. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  189. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  190. Qi J, et al. 2021. Nat Commun. 12:4755. PubMed
  191. Tseng SH, et al. 2021. J Biomed Sci. 28:63. PubMed
  192. Shannon JP, et al. 2021. STAR Protoc. 2:100790. PubMed
  193. Zheng Z, et al. 2021. Nat Commun. 12:6202. PubMed
  194. He X, et al. 2021. J Immunother Cancer. 9:. PubMed
  195. Alikhanyan K, et al. 2021. Cancers (Basel). 13:. PubMed
  196. Li H, et al. 2021. Nat Commun. 12:7149. PubMed
  197. Jiang Q, et al. 2022. Theranostics. 12:59. PubMed
  198. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  199. Zhao X, et al. 2022. Front Mol Biosci. 9:786864. PubMed
  200. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  201. Bhattacharya P, et al. 2022. PLoS Negl Trop Dis. 16:e0010224. PubMed
  202. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  203. Tian H, et al. 2022. Cancer Sci. 113:875. PubMed
  204. Takahashi F, et al. 2022. iScience. 25:104278. PubMed
  205. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  206. Dourcy M, et al. 2020. Mucosal Immunol. 13:799. PubMed
  207. Nagatake T, et al. 2021. Int Immunol. 33:171. PubMed
  208. Ding P, et al. 2022. Bone Res. 10:42. PubMed
  209. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  210. Bommireddy R, et al. 2020. Vaccines (Basel). 8:. PubMed
  211. Dey S, et al. 2020. J Immunother Cancer. 8:. PubMed
  212. Otvos B, et al. 2021. Clin Cancer Res. 27:2038. PubMed
  213. Yang Z, et al. 2021. Onco Targets Ther. 14:4239. PubMed
  214. Smith LK, et al. 2021. Elife. 10:. PubMed
  215. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  216. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  217. del Rio ML, et al. 2021. Transl Res. Online ahead of print.. PubMed
  218. Wu H, et al. 2021. Cell Death Discov. 7:225. PubMed
  219. Yin Y, et al. 2021. ACS Nano. 15:14347. PubMed
  220. Goldfarb Y, et al. 2021. J Exp Med. 218:. PubMed
  221. He X, et al. 2021. Adv Sci (Weinh). 8:e2103023. PubMed
  222. Chen B, et al. 2021. Cell. 184:6262. PubMed
  223. Wang J, et al. 2022. Clin Transl Med. 12:e718. PubMed
  224. Shen M, et al. 2022. Nat Cancer. 3:60. PubMed
  225. Zhang Q, et al. 2022. Nat Commun. 13:2406. PubMed
  226. Zhou P, et al. 2022. Mol Ther Oncolytics. 25:236. PubMed
  227. Zhang C, et al. 2022. Nat Commun. 13:3468. PubMed
  228. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  229. Li C, et al. 2022. Front Cell Dev Biol. 10:913824. PubMed
  230. Si L, et al. 2022. Nat Biotechnol. 40:1370. PubMed
  231. Kataru RP, et al. 2022. Front Aging. 3:864860. PubMed
  232. Li YN, et al. 2022. Nat Commun. 13:4074. PubMed
  233. Zhao X, et al. 2022. iScience. 25:104690. PubMed
  234. Zhang J, et al. 2022. Front Immunol. 13:931740. PubMed
  235. Bian L, et al. 2022. Front Immunol. 13:938598. PubMed
  236. Zheng Y, et al. 2022. Transl Res. :. PubMed
  237. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  238. Sun Y, et al. 2022. iScience. 25:104846. PubMed
  239. Liu T, et al. 2022. Front Immunol. 13:901349. PubMed
  240. Li ZX, et al. 2022. Arch Virol. :. PubMed
  241. Schreiber K, et al. 2020. Cancer Immunol Res. 8:192. PubMed
  242. Zhang Z, et al. 2020. Nature. 579:415. PubMed
  243. Bessell CA, et al. 2020. JCI Insight. 5:. PubMed
  244. Murata T, et al. 2020. Sci Rep. 10:13560. PubMed
  245. Harrison DK, et al. 2021. Transplantation. 105:540. PubMed
  246. Rao L, et al. 2020. Nat Commun. 11:4909. PubMed
  247. Ebina-Shibuya R, et al. 2021. Elife. 10:. PubMed
  248. Pervaiz N, et al. 2021. Pigment Cell Melanoma Res. 34:918. PubMed
  249. He X, et al. 2021. Small. 17:e2007165. PubMed
  250. Huber MK, et al. 2021. J Vis Exp. :. PubMed
  251. Funk KE, et al. 2021. Aging Cell. 20:e13412. PubMed
  252. He X, et al. 2022. Cancer Immunol Res. 10:314. PubMed
  253. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  254. Chen H, et al. 2022. Front Pharmacol. 13:827520. PubMed
  255. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  256. Zhang Y, et al. 2022. J Immunother Cancer. 10:. PubMed
  257. Frey N, et al. 2022. Nat Commun. 13:1804. PubMed
  258. Feng Y, et al. 2022. J Nanobiotechnology. 20:193. PubMed
  259. Liu YW, et al. 2022. JCI Insight. 7:. PubMed
  260. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  261. Guo H, et al. 2022. PLoS Pathog. 18:e1010857. PubMed
  262. Fonderflick L, et al. 2022. Cells. 11:. PubMed
  263. Stone VM, et al. 2022. iScience. 25:105070. PubMed
  264. Ghosh S, et al. 2022. APL Bioeng. 6:036105. PubMed
  265. Bauer KM, et al. 2022. JCI Insight. 7:. PubMed
  266. Mayer RL, et al. 2022. Nat Commun. 13:6075. PubMed
  267. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  268. Zelenka T, et al. 2022. Nat Commun. 13:6954. PubMed
  269. Behr FM, et al. 2021. Eur J Immunol. 51:151. PubMed
  270. Thomas R, et al. 2021. Immunology. 163:478. PubMed
  271. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  272. Schenkel JM, et al. 2021. Immunity. 54:2338. PubMed
  273. Kragten NAM, et al. 2022. Eur J Immunol. 52:389. PubMed
  274. Li X, et al. 2022. J Clin Invest. 132: . PubMed
  275. Chakraborty P, et al. 2022. Cancer Res. 82:1969. PubMed
  276. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  277. Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed
  278. Zhao Z, et al. 2022. Adv Sci (Weinh). 9:e2201293. PubMed
  279. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  280. Marié IJ, et al. 2022. Bio Protoc. 12:e4438. PubMed
  281. Backlund C, et al. 2022. Proc Natl Acad Sci U S A. 119:e2204078119. PubMed
  282. Xie DH, et al. 2022. Med Phys. 49:6728. PubMed
  283. Chen Y, et al. 2023. Adv Healthc Mater. 12:e2202085. PubMed
  284. Theofilatos D, et al. 2022. STAR Protoc. 3:101839. PubMed
  285. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  286. You Q, et al. 2023. Adv Mater. 35:e2204910. PubMed
  287. Yu J, et al. 2022. Nat Commun. 13:7903. PubMed
  288. Morrow RJ, et al. 2022. Cells. 11: . PubMed
  289. Zhao X, et al. 2022. STAR Protoc. 3:101859. PubMed
  290. Ding D, et al. 2023. J Med Chem. 66:1467. PubMed
  291. Lin J, et al. 2023. Nat Commun. 14:224. PubMed
  292. Smith LA, et al. 2023. Front Oncol. 12:1031174. PubMed
  293. Ali LR, et al. 2023. J Exp Med. 220: . PubMed
  294. Kasuya T, et al. 2023. Sci Rep. 13:1653. PubMed
  295. Wang R, et al. 2023. NPJ Vaccines. 8:6. PubMed
  296. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  297. Zheng J, et al. 2023. Biomater Res. 27:9. PubMed
  298. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  299. Scherer S, et al. 2023. Nat Immunol. 24:501. PubMed
  300. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  301. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  302. Puth S, et al. 2022. Biomaterials. 286:121542. PubMed
  303. Guo A, et al. 2022. Nature. 607:135. PubMed
  304. Chen R, et al. 2022. J Mol Cell Biol. 14:. PubMed
  305. Konjar S, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202144119. PubMed
  306. Cheng C, et al. 2022. Cell Mol Gastroenterol Hepatol. 15:261. PubMed
  307. Pagni RL, et al. 2022. Front Immunol. 13:1005937. PubMed
  308. Chen H, et al. 2023. Nat Commun. 14:941. PubMed
  309. Li X, et al. 2023. J Clin Invest. 133:. PubMed
  310. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  311. Saha S, et al. 2023. Sci Rep. 13:4609. PubMed
  312. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  313. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  314. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  315. Wu N, et al. 2023. Front Bioeng Biotechnol. 11:1173381. PubMed
  316. Zhang YT, et al. 2023. Front Immunol. 14:1085456. PubMed
  317. Zhang J, et al. 2023. Theranostics. 13:2226. PubMed
  318. Yu L, et al. 2023. Front Oncol. 13:1174713. PubMed
  319. He Y, et al. 2023. Biomolecules. 13:. PubMed
  320. Deng G, et al. 2023. Cancers (Basel). 15:. PubMed
  321. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  322. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  323. Wang D, et al. 2023. Nat Commun. 14:2943. PubMed
  324. Li M, et al. 2023. BMC Cancer. 23:497. PubMed
  325. Zeng S, et al. 2023. Front Oncol. 13:1171926. PubMed
  326. Lan Y, et al. 2023. iScience. 26:106817. PubMed
  327. Zhang AQ, et al. 2023. Nat Biomed Eng. . PubMed
  328. Song S, et al. 2023. Bioact Mater. 28:358. PubMed
RRID
AB_312750 (BioLegend Cat. No. 100711)
AB_312751 (BioLegend Cat. No. 100712)

Antigen Details

Structure
Ig superfamily, CD8α chain, 34 kD
Distribution

Most thymocytes, T cell subset, some NK cells, lymphoid dendritic cells

Function
Co-receptor for TCR
Ligand/Receptor
MHC class I molecule
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Zamoyska R. 1994. Immunity 1:243.
3. Ellmeier W, et al. 1999. Annu. Rev. Immunol. 17:523.

Gene ID
12525 View all products for this Gene ID
UniProt
View information about CD8alpha on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 01.21.2014

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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