Loading...

PE anti-human CD38 Antibody

Pricing & Availability
Clone
HIT2 (See other available formats)
Regulatory Status
RUO
Workshop
III 155
Other Names
T10, ADP-ribosyl cyclase
Isotype
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
publications
HIT2
Human peripheral blood lymphocytes stained with HIT2 PE
  • HIT2
    Human peripheral blood lymphocytes stained with HIT2 PE
See PE spectral data
Cat # Size Price Quantity Check Availability Save
303505 25 tests 36€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
303506 100 tests 88€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6 and spatial biology (IBEX)10,11.

Application References
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373.
  3. Esser M, et al. 2001. J. Virol. 75:6173.
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044.
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107.
  6. van der Voort R, et al. 1997. J. Exp. Med. 185:2121. (IHC)
  7. Bende RJ, et al. 2003. Am. J. Pathol. 162:105.
  8. Lehner M, et al. 2008. J. Leukoc. Biol. 83:883. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Schelker RC, et al. 2018. Hematology. 1.192361111. PubMed
  2. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  3. Osorio FG et al. 2018. Cell reports. 25(9):2308-2316 . PubMed
  4. Munteanu AN, et al. 2019. Exp Ther Med. 18:1693. PubMed
  5. Hagan T, et al. 2020. Cell. 178(6):1313-1328.e13.. PubMed
  6. Li Z, et al. 2014. PLoS One. 9:106064. PubMed
  7. Kreye J, et al. 2020. Cell. 183(4):1058-1069.e19. PubMed
  8. Hasaart KAL, et al. 2020. Sci Rep. 10:12991. PubMed
  9. Kreye J, et al. 2020. bioRxiv. . PubMed
  10. Fathy El-Metwaly N, et al. 2021. Asian Pac J Cancer Prev. 22:3237. PubMed
  11. Saygin C, et al. 2021. Leukemia. 35:3406. PubMed
  12. Brandsma AM, et al. 2021. Cancer Discov. . PubMed
  13. Brandsma AM, et al. 2021. Blood Cancer Discov. 2:484. PubMed
  14. Zhou L, et al. 2021. Transl Cancer Res. 10:5307. PubMed
  15. Zhou L, et al. 2021. Transl Cancer Res. 10:3364. PubMed
  16. Hasaart KAL, et al. 2022. iScience. 25:103736. PubMed
  17. Rosendahl Huber A, et al. 2022. STAR Protoc. 3:101361. PubMed
  18. de Kanter JK, et al. 2021. Cell Stem Cell. 28:1726. PubMed
  19. Csomós K, et al. 2022. Nat Immunol. 23:1256. PubMed
  20. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  21. Li H, et al. 2023. Clin Rheumatol. 42:1327. PubMed
  22. Chernyshev M, et al. 2023. Nat Commun. 14:2249. PubMed
RRID
AB_314357 (BioLegend Cat. No. 303505)
AB_314358 (BioLegend Cat. No. 303506)

Antigen Details

Structure
ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD
Distribution

T cells, B cells, NK, myeloid, plasma, and dendritic cells

Function
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, Dendritic cells, NK cells, Plasma cells, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151.
2. Lund F, et al. 1995. Immunol. Today 16:469.

Gene ID
952 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 12.16.2021

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account