- Clone
- 5D3/CLEC12A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![5D3slashCLEC12A_APC_CLEC12A_Antibody_FC_1_091014.jpg 5D3slashCLEC12A_APC_CLEC12A_Antibody_FC_1_091014.jpg](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/5D3slashCLEC12A_APC_CLEC12A_Antibody_FC_1_091014.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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C57BL/6 mouse splenocytes were stained with CD8 PE, CD11c FITC, and CD371 (CLEC12A, clone 5D3/CLEC12A) APC (top) or rat IgG2a, κ APC isotype control (bottom). Data was gated on CD8 positive cell population. -
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
143405 | 25 µg | 142 CHF | ||||
143406 | 100 µg | 362 CHF |
CD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family. Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases. Mouse CLEC12A is expressed on CD8+ dendritic cells (DCs), a proportion of CD8- dendritc cells, plasmacytoid DCs, monoctyes, macrophages, granulocytes, and B cells.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- CHO expressing mouse CLEC12A
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
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Red Laser (633 nm)
- Product Citations
-
- RRID
-
AB_2564264 (BioLegend Cat. No. 143405)
AB_2564265 (BioLegend Cat. No. 143406)
Antigen Details
- Structure
- Type II C-type lectin family member, 265 aa, 30.7 kD
- Distribution
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CD8+ dendritic cells (DCs), a proportion of CD8- dendritic cells, plasmacytoid DCs, monocytes, macrophages, granulocytes, B cells
- Function
- Negative regulator of granuocyte and monocyte function
- Interaction
- PTPN6 and PTPN11
- Cell Type
- B cells, Dendritic cells, Embryonic Stem Cells, Granulocytes, Macrophages, Monocytes
- Biology Area
- Costimulatory Molecules, Immunology, Innate Immunity, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
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1. Lahoud MH, et al. 2009. J. Immunol. 182:7587.
2. Chen CH, et al. 2006. Blood 107:1459.
3. Marshall AS, et al. 2004. J. Biol. Chem. 279:14792. - Gene ID
- 232413 View all products for this Gene ID
- UniProt
- View information about CD371 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CD371 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse CD371 (CLEC12A) | 5D3/CLEC12A | FC |
PE anti-mouse CD371 (CLEC12A) | 5D3/CLEC12A | FC |
APC anti-mouse CD371 (CLEC12A) | 5D3/CLEC12A | FC |
TotalSeq™-A0825 anti-mouse CD371 (CLEC12A) | 5D3/CLEC12A | PG |
TotalSeq™-C0825 anti-mouse CD371 (CLEC12A) | 5D3/CLEC12A | PG |
TotalSeq™-B0825 anti-mouse CD371 (CLEC12A) Antibody | 5D3/CLEC12A | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD371 (CLEC12A)
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PE anti-mouse CD371 (CLEC12A)
C57BL/6 mouse splenocytes were stained with CD8 PerCP, CD11c... -
APC anti-mouse CD371 (CLEC12A)
C57BL/6 mouse splenocytes were stained with CD8 PE, CD11c FI... -
TotalSeq™-A0825 anti-mouse CD371 (CLEC12A)
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TotalSeq™-C0825 anti-mouse CD371 (CLEC12A)
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TotalSeq™-B0825 anti-mouse CD371 (CLEC12A) Antibody
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