- Clone
- S21013E (See other available formats)
- Regulatory Status
- RUO
- Other Names
- C-C chemokine receptor-like 2, L-CCR, Lipopolysaccharide-inducible C-C chemokine receptor (L-CCR), Cmkbr1l2, Ackr5
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![S21013E_FITC_CCRL2_Antibody_1_050324 S21013E_FITC_CCRL2_Antibody_1_050324](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/S21013E_FITC_CCRL2_Antibody_1_050324.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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C57BL/6 mouse peritoneal macrophages were stained with anti-mouse F4/80 (clone BM8) APC and anti-mouse CCRL2 (clone S21013E) FITC (left) or rat IgG2b, κ FITC isotype control (right).
Cat # | Size | Price | Quantity Check Availability | Save | ||
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114009 | 25 µg | 136 CHF | ||||
114010 | 100 µg | 311 CHF |
CCRL2 (C-C chemokine receptor-like 2) is also known as Lipopolysaccharide-inducible C-C chemokine receptor (L-CCR/Lccr). CCRL2 is a chemokine receptor-like, 7-transmembrane protein that can bind CCL19 or chemerin/RARRES2. Mouse CCRL2 is expressed by several leukocytes, including dendritic cells, macrophages, neutrophils, and microglia and is rapidly upregulated following stimulation with proinflammatory stimuli, such as LPS and TNF-α. CCRL2 plays various roles in regulating chemokine activities, e.g., by binding and internalizing excess local levels of the CCL19/MIP-3β chemokine. Alternatively, endothelial cell-expressed CCRL2 can bind & present the chemerin/RARRES2 chemoattractant to lymphoid cells that express the functional signaling receptor, CMKLR1, and promote their adhesion.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse CCRL2-Transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
- Application Notes
-
Clone S21013E completely blocks the reference clone BZ2E3.
Antigen Details
- Structure
- C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seventransmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family.
- Distribution
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Expressed in many leukocytes, including dendritic cells, macrophages, neutrophils, mast cells, microglia & astrocytes
- Function
- CC-chemokine receptor-like 2 (CCRL2) binds leukocyte chemoattractant chemerin and can regulate local levels of the attractant, but does not itself support cell migration.
- Interaction
- Macrophages, Dendritic Cells, Mast Cells
- Ligand/Receptor
- CCL19 and chemerin/RARRES2 bind to CCRL2
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
- Monnier J, et al. 2012. J Immunol. 2012; 189:956-67.
- Shimada T, et al. 1998. FEBS Lett. 1998; 425:490-4
- Yoshimura T, et al. 2011. Exp Cell Res. 317:674-84.
- Zabel BA, et al. 2008. J Exp Med. 205:2207-20
- Gene ID
- 54199 View all products for this Gene ID
- UniProt
- View information about CCRL2 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CCRL2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse CCRL2 | S21013E | FC |
PE anti-mouse CCRL2 | S21013E | FC |
Brilliant Violet 421™ anti-mouse CCRL2 | S21013E | FC |
APC anti-mouse CCRL2 | S21013E | FC |
FITC anti-mouse CCRL2 | S21013E | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CCRL2
C57BL/6 mouse peritoneal macrophages were stained with anti-... C57BL/6 mouse peritoneal macrophages were stained with anti-... -
PE anti-mouse CCRL2
C57BL/6 mouse peritoneal macrophages were stained with anti-... C57BL/6 mouse peritoneal macrophages were stained with anti-... -
Brilliant Violet 421™ anti-mouse CCRL2
C57BL/6 mouse peritoneal macrophages were stained with anti-... C57BL/6 mouse peritoneal macrophages were stained with anti-... -
APC anti-mouse CCRL2
C57BL/6 mouse peritoneal macrophages were stained with anti-... C57BL/6 mouse peritoneal macrophages were stained with anti-... -
FITC anti-mouse CCRL2
C57BL/6 mouse peritoneal macrophages were stained with anti-...
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