Purified anti-ASIC1 Antibody (Previously Covance catalog# MMS-5261)

Pricing & Availability
Clone
N271/44 (See other available formats)
Regulatory Status
RUO
Other Names
ACCN2, ASIC, BNaC2, Acid-sensing ion channel 1, degenerin 2, brain sodium channel 2, acid sensing ion channel, amiloride-sensitive cation channel 2, neuronal
Previously
Covance Catalog# MMS-5261
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
N271slash44_Purified_ASIC1_Antibody_101917
Western blot of anti-ASIC1 antibody (clone N271/44). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain membrane lysate; Lane 3: 20 µg of mouse brain membrane lysate; Lane 4: 20µg of rat brain membrane lysate. The blot was incubated with 10 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP labeled goat anti-mouse IgG (Cat# 405301). Enhanced chemiluminescence was used as the detection system.
  • N271slash44_Purified_ASIC1_Antibody_101917
    Western blot of anti-ASIC1 antibody (clone N271/44). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain membrane lysate; Lane 3: 20 µg of mouse brain membrane lysate; Lane 4: 20µg of rat brain membrane lysate. The blot was incubated with 10 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP labeled goat anti-mouse IgG (Cat# 405301). Enhanced chemiluminescence was used as the detection system.
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833501 100 µL 165 CHF
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Description

Acid-sensing ion channel (ASIC) 1, also known as brain sodium channel (BNaC2), degenerin 2 and amiloride-sensitive cation channel 2 (ACCN2), is a sodium channel activated by extracellular protons that is expressed in nearly all neurons. ASIC1 may play a role in learning, pain transduction, memory development, and fear conditioning.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1 mg/ml
Storage & Handling
This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
Application

WB

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting.

The optimal working dilution should be determined for each specific assay condition.
WB: 4-10 µg/ml

Application Notes

This antibody is effective in immunoblotting (WB).

*Expected MW: 60 kD

WB Positive Control: Human, mouse and rat brain membrane lysates. This clone cross-reacts with human ASIC1, however detection level is weaker than that observed with mouse or rat AISC1.

RRID
AB_2564967 (BioLegend Cat. No. 833501)

Antigen Details

Biology Area
Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
Molecular Family
Postsynaptic proteins, Presynaptic proteins
Gene ID
11419 View all products for this Gene ID
UniProt
View information about ASIC1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 6    Revision Date: 07.09.2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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