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- Clone
- QA21A07 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD40L, TNFSF5, T-BAM, gp39
- Isotype
- Human IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood mononuclear cells were treated with Cell Activation Cocktail (without Brefeldin A) (Cat. No. 423302). Cells were stained with purified anti-human CD154 recombinant (clone QA21A07) (left) or purified human IgG1, к isotype control (right) followed by anti-human IgG PE. Cells were costained with anti-human CD4 APC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 388302 | 100 µg | 210 CHF | ||||
CD154, also known as CD40L, TNFSF5, T-BAM, and gp39, is a 32-39 kD type II transmembrane glycoprotein member of the TNF superfamily expressed on activated T cells. CD154 interacts as a costimulatory molecule with CD40 on B cells to induce B cell activation, resulting in proliferation, immunoglobulin production, and Ig isotype switching. CD40L also may regulate T cell cytokine production.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Human
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone QA21A07 can completely block the binding of clone 24-31 on target cells.
Antigen Details
- Structure
- 32-39 kD type II transmembrane glycoprotein of the TNF superfamily
- Distribution
-
Activated T cells
- Function
- B cell costimulation
- Ligand/Receptor
- CD40
- Cell Type
- T cells, Tregs
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- van Kooten C and Banchereau JN. 2000. J Leukoc Biol. 67:2-17.
- Ford GS, et al. 1999. J Immunol. 162:4037-44.
- Gene ID
- 959 View all products for this Gene ID
- UniProt
- View information about CD154 on UniProt.org
Related FAQs
Other Formats
View All CD154 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD154 Recombinant Antibody | QA21A07 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD154 Recombinant Antibody
Human peripheral blood mononuclear cells were treated with C...
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