Purified anti-human CD95 (Fas) Recombinant Antibody

Pricing & Availability
Clone
QA18A50 (See other available formats)
Regulatory Status
RUO
Other Names
Fas, APO-1, TNFRSF6
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA18A50_PURE_CD95_Fas_RECOM_Antibody_111820
Human peripheral blood lymphocytes were stained with purified anti-human CD95 (Fas) recombinant (clone QA18A50) (filled histogram) or mouse IgG1, κ isotype control (open histogram) followed by anti-mouse IgG PE.
  • QA18A50_PURE_CD95_Fas_RECOM_Antibody_111820
    Human peripheral blood lymphocytes were stained with purified anti-human CD95 (Fas) recombinant (clone QA18A50) (filled histogram) or mouse IgG1, κ isotype control (open histogram) followed by anti-mouse IgG PE.
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325002 100 µg 183 CHF
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Description

CD95 is a 45 kD single chain type I glycoprotein also known as Fas, APO-1, and TNFRSF6. It is a member of the TNF receptor superfamily. CD95 is expressed on T and B lymphocytes, monocytes, neutrophils, and fibroblasts. CD95 expression is upregulated by activation. The extracellular region of CD95 binds to CD178 (Fas ligand). CD178 binding to CD95 induces apoptosis and has been shown to play a role in the maintenance of peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Immunogen
Human CD95 transfected L cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone QA18A50 antibody is able to completely block binding of clone DX2 on target cells.

This recombinant antibody clone is derived from clone DX2.

RRID
AB_2888840 (BioLegend Cat. No. 325002)

Antigen Details

Structure
TNFR superfamily, type I transmembrane protein, 45 kD
Distribution

T cells and B cells, monocytes, neutrophils, fibroblasts, expression level upregulated on activated lymphocytes

Function
Mediates apoptosis
Ligand/Receptor
Fas ligand (CD178)
Cell Type
B cells, Dendritic cells, Fibroblasts, Granulocytes, Lymphocytes, Monocytes, Neutrophils, T cells
Biology Area
Adaptive Immunity, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Death, Immunology, Neuroscience, Signal Transduction
Molecular Family
CD Molecules
Antigen References

  1. Krammer P, et al. 1994. Immunol. Rev. 142:175.
  2. Nagata S, et al. 1995. Science 267:1449.

Gene ID
355 View all products for this Gene ID
UniProt
View information about CD95 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 03.26.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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