Purified anti-mouse/rat CD161f (NKPR1f) Antibody

Pricing & Availability
Clone
C8 (See other available formats)
Regulatory Status
RUO
Other Names
Killer cell lectin-like receptor subfamily B member 1F (Klrb1f), Nkr-p1f, Nkrp1-f, A630024B12Rik
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
C8_Purified_NKRP1F_Antibody_FC_1_091014.jpg
C57BL/6 splenocytes were stained with NK1.1 APC and purified NKRP1f (clone C8) (top) or rat IgG1, κ istoype control (bottom), followed by anti-rat IgG PE.
  • C8_Purified_NKRP1F_Antibody_FC_1_091014.jpg
    C57BL/6 splenocytes were stained with NK1.1 APC and purified NKRP1f (clone C8) (top) or rat IgG1, κ istoype control (bottom), followed by anti-rat IgG PE.
  • C8_Purified_NKRP1F_Antibody_FC_2_091014
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148902 100 µg 229 CHF
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Description

CD161, also known as NKRP1f, is mainly expressed on NK cells with little to no expression on T or B cells. NKRP1f on the surface of dendritic cells can bind to Clr-g expressed on activated T cells and result in production of IL-2 and proliferation of T cells. NKRP1f may also play a role in the formation of synapses between T cells and antigen presenting dendritic cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Rat
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
NKRP1f transfected YB2/0 rat plasmacytoma cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Mortazavi F, et al. 2019. Bio Protoc. e3321:9. PubMed
RRID
AB_2564270 (BioLegend Cat. No. 148902)

Antigen Details

Structure
CLR family, 24.7 kD, ITIM-less activation receptor
Distribution
NK cells, dendritic cells
Function
Facilitates IL-2 production and proliferation of T cells and may contribute to the formation of immunological synapses.
Ligand/Receptor
Clr-g
Cell Type
NK cells, Dendritic cells
Biology Area
Cell Biology, Immunology, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Skálová T, et al. 2012. J. Immunol. 189:4881.
2. Tian W, et al. 2005. Cell Immunol. 234:39.
3. Plougastel B, et al. 2001. Immunogenetics. 53:592.
4. Kveberg L, et al. 2011. Immunogenetics. 63:429.

Gene ID
232408 View all products for this Gene ID
UniProt
View information about CD161f on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09.15.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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