Loading...

APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
123115 25 µg 40€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
123116 100 µg 115€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  2. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  3. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  4. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  5. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  6. Czimmerer Z, et al. 2022. Immunity. 55:2006. PubMed
  7. Amodio V, et al. 2023. Cancer Cell. 41:196. PubMed
  8. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  9. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  10. Liu PS, et al. 2023. Nat Immunol. 24:452. PubMed
  11. Mizutani T, et al. 2023. iScience. 26:106081. PubMed
  12. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  13. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  14. Wang Y, et al. 2023. EBioMedicine. 90:104480. PubMed
  15. Tan J, et al. 2023. Acta Pharm Sin B. 13:632. PubMed
  16. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  17. Zhu S, et al. 2023. J Nanobiotechnology. 21:81. PubMed
  18. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  19. He XY, et al. 2023. Nat Commun. 14:2253. PubMed
  20. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  21. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  22. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  23. Shen Z, et al. 2023. iScience. 26:106572. PubMed
  24. Ji Y, et al. 2023. Nat Cell Biol. 25:726. PubMed
  25. He Y, et al. 2023. Biomolecules. 13:. PubMed
  26. Wang C, et al. 2023. Int J Oral Sci. 15:19. PubMed
  27. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  28. Song S, et al. 2023. Bioact Mater. 28:358. PubMed
  29. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  30. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  31. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  32. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  33. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  34. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  35. Yang D, et al. 2022. Cell. 185:1905. PubMed
  36. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  37. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  38. Nesseler JP, et al. 2020. Cancers (Basel). 12: . PubMed
  39. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  40. Fang C, et al. 2022. J Pathol. 256:310. PubMed
  41. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  42. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  43. Yousefi M, et al. 2022. Cancer Res. 82:1589. PubMed
  44. Chen J, et al. 2022. Adv Sci (Weinh). 9:e2200668. PubMed
  45. Sipilä K, et al. 2022. Dev Cell. 57:1453. PubMed
  46. Jang HJ, et al. 2022. Cancer Res. 82:2593. PubMed
  47. Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed
  48. Xu J, et al. 2022. Invest Ophthalmol Vis Sci. 63:15. PubMed
  49. Schaue D, et al. 2022. Antioxidants (Basel). 11: . PubMed
  50. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  51. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  52. Yoo HJ, et al. 2022. Cell Rep. 41:111598. PubMed
  53. Nagre N, et al. 2022. Respir Res. 23:326. PubMed
  54. Miao Y, et al. 2022. Front Pharmacol. 13:1032741. PubMed
  55. Kuo CS, et al. 2022. Elife. 11: . PubMed
  56. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  57. Wang R, et al. 2023. Nat Biomed Eng. 7:38. PubMed
  58. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  59. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  60. Wang Y, et al. 2023. FASEB J. 37:e22776. PubMed
  61. Fontana MF, et al. 2023. Elife. 12: . PubMed
  62. Kulkarni R, et al. 2023. Life Sci Alliance. 6: . PubMed
  63. Slusarczyk P, et al. 2023. Elife. 12: . PubMed
  64. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  65. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  66. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  67. Li FJ, et al. 2022. Am J Physiol Lung Cell Mol Physiol. 322:L593. PubMed
  68. Kraynak CA, et al. 2022. Int J Pharm. 618:121634. PubMed
  69. Fernández-García V, et al. 2022. Biomed Pharmacother. 148:112769. PubMed
  70. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  71. Quattrocelli M, et al. 2022. J Exp Med. 219:. PubMed
  72. Hailemichael Y, et al. 2022. Cancer Cell. 40:509. PubMed
  73. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  74. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  75. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  76. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  77. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  78. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  79. Kim SE, et al. 2019. Nutrients. 11. PubMed
  80. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  81. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  82. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  83. He R, et al. 2021. J Immunol. 206:2353. PubMed
  84. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  85. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  86. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  87. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  88. He F, et al. 2021. J Exp Med. 218:. PubMed
  89. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  90. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  91. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  92. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  93. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  94. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  95. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  96. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  97. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  98. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  99. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  100. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  101. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  102. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  103. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  104. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  105. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  106. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  107. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  108. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  109. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  110. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  111. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  112. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  113. Dong L, et al. 2021. Cancer Cell. . PubMed
  114. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  115. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  116. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  117. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  118. Han J, et al. 2022. FEBS J. 289:417. PubMed
  119. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  120. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  121. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  122. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  123. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  124. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  125. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  126. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  127. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  128. Sun P, et al. 2015. J Hepatol. . PubMed
  129. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  130. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  131. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  132. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  133. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  134. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  135. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  136. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  137. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  138. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  139. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  140. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  141. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  142. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  143. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  144. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  145. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  146. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  147. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  148. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  149. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  150. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  151. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  152. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  153. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  154. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  155. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  156. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  157. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  158. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  159. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  160. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  161. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  162. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  163. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  164. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  165. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  166. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  167. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  168. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  169. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  170. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  171. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  172. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  173. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  174. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  175. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  176. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  177. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  178. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  179. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  180. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  181. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  182. Oatley J, et al. 2009. Development. 136:1191. PubMed
  183. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  184. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  185. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  186. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  187. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  188. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  189. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  190. Lv F, et al. 2022. iScience. 25:103639. PubMed
  191. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  192. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  193. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  194. Gao H, et al. 2021. Cells. 10:. PubMed
  195. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  196. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  197. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  198. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  199. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  200. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  201. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  202. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  203. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  204. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  205. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  206. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  207. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  208. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  209. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  210. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  211. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  212. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  213. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  214. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  215. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  216. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  217. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  218. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  219. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  220. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  221. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  222. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  223. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  224. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  225. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  226. Matundan H, et al. 2019. J Virol. 93. PubMed
  227. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  228. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  229. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  230. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  231. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  232. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  233. Yang Y, et al. 2022. Elife. 11:. PubMed
  234. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  235. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  236. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  237. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  238. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  239. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  240. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  241. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  242. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  243. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  244. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  245. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  246. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  247. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  248. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  249. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  250. Lang V, et al. 2021. Elife. 10:. PubMed
  251. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  252. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  253. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  254. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  255. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  256. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  257. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  258. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  259. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  260. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  261. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  262. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  263. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  264. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  265. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  266. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  267. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  268. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  269. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  270. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  271. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  272. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  273. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  274. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  275. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  276. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  277. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  278. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  279. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  280. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  281. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  282. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  283. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  284. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  285. Engblom C, et al. 2017. Science. 358:6367. PubMed
  286. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  287. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  288. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  289. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  290. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  291. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  292. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  293. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  294. Calle P, et al. 2021. Cells. 10:. PubMed
  295. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  296. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  297. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  298. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  299. Deng W, et al. 2015. Clin Immunol. . PubMed
  300. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  301. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  302. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  303. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  304. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  305. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  306. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  307. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  308. Horsle B 2013. Development. 140:1517. PubMed
  309. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  310. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  311. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  312. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  313. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  314. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  315. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  316. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  317. Karki R, et al. 2020. bioRxiv. . PubMed
  318. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  319. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  320. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  321. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  322. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  323. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  324. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  325. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  326. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  327. Gu H, et al. 2021. Elife. 10:. PubMed
  328. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  329. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  330. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  331. Karki R, et al. 2021. Cell. 184:149. PubMed
  332. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  333. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  334. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  335. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  336. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  337. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  338. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  339. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  340. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  341. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  342. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  343. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  344. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  345. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  346. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  347. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  348. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  349. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  350. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  351. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  352. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  353. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  354. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  355. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  356. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  357. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  358. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  359. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  360. Liu SS, et al. 2021. Immunity. :. PubMed
  361. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  362. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  363. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  364. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  365. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  366. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  367. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  368. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  369. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  370. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  371. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  372. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  373. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  374. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  375. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  376. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  377. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  378. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  379. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  380. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  381. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  382. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  383. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  384. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  385. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  386. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  387. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  388. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  389. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  390. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  391. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  392. Lalor R, et al. 2019. Nutrients. 11. PubMed
  393. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  394. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  395. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  396. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  397. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
  398. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  399. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  400. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  401. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
  402. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
RRID
AB_893493 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
F4/80
Specificity Alt (DOES NOT SHOW ON TDS):
F4/80
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about F4/80 on UniProt.org

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account