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PE/Cyanine7 anti-human CD38 Antibody

Pricing & Availability
Clone
HIT2 (See other available formats)
Regulatory Status
RUO
Workshop
III 155
Other Names
T10, ADP-ribosyl cyclase
Isotype
Mouse IgG1, κ
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Product Citations
publications
HIT2_PECy7_021009.jpg
Human peripheral blood lymphocytes stained with HIT2 PE/Cyanine7
  • HIT2_PECy7_021009.jpg
    Human peripheral blood lymphocytes stained with HIT2 PE/Cyanine7
See PE/Cyanine7 spectral data
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303515 25 tests 123€
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303516 100 tests 249€
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6 and spatial biology (IBEX)10,11.

Additional Product Notes

BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.

Application References
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373.
  3. Esser M, et al. 2001. J. Virol. 75:6173.
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044.
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107.
  6. van der Voort R, et al. 1997. J. Exp. Med. 185:2121. (IHC)
  7. Bende RJ, et al. 2003. Am. J. Pathol. 162:105.
  8. Lehner M, et al. 2008. J. Leukoc. Biol. 83:883. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Audigé A, et al. 2017. BMC Immunology. 10.1186/s12865-017-0209-9. PubMed
  2. Shoda H, et al. 2017. Arthritis Research & Therapy . 10.1186/s13075-017-1308-y. PubMed
  3. Setliff I, et al. 2018. Cell Host Microbe. 23:845. PubMed
  4. Dutta AK, et al. 2019. Leukemia. 33:457. PubMed
  5. Neu KE, et al. 2019. J Clin Invest. 129:93. PubMed
  6. Fu J et al. 2019. Cell stem cell. 24(2):227-239 . PubMed
  7. Shan L, et al. 2017. Immunity. 47:766. PubMed
  8. Salazar-Camarena DC, et al. 2020. Sci Rep. 10:6236. PubMed
  9. Singh A, et al. 2020. Cell Rep. 32:108153. PubMed
  10. Katsuyama E, et al. 2020. Cell Reports. 30(1):112-123.e4.. PubMed
  11. Chaimowitz N, et al. 2011. J Immunol. 187:5114. PubMed
  12. Hofmann M, et al. 2012. Leukemia. 26:1288. PubMed
  13. Weinberg A, et al. 2015. PLoS One. 10:122431. PubMed
  14. Boisson B, et al. 2015. J Exp Med. 212:939. PubMed
  15. Inui M, et al. 2015. Int Immunol. 27: 345 - 355. PubMed
  16. Lorkova L, et al. 2015. PLoS One. 10: 0135314. PubMed
  17. Ishizaka A, et al. 2016. J Virol. 90: 5665 - 5676. PubMed
  18. Hoffmann M, et al. 2016. PLoS Pathog. 12: 1005661. PubMed
  19. Nagafuchi Y, et al. 2016. Sci Rep. 6:29338. PubMed
  20. S Tzeng 2016. J Vis Exp. 118:e54582. PubMed
  21. Tsuchida Y, et al. 2017. PLoS One. 10.1371/journal.pone.0169646. PubMed
  22. , et al. 2020. Haematologica. 105:2795. PubMed
  23. Trivedi S, et al. 2020. Elife. 9:00. PubMed
  24. Riether C, et al. 2021. Cell Reports. 34(4):108663. PubMed
  25. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  26. Fu Y, et al. 2021. Cell Reports. 36(2):109344. PubMed
  27. Wang X, et al. 2021. Cell Discovery. 7(1):60. PubMed
  28. Tavor S, et al. 2020. Haematologica. . PubMed
  29. Lal A, et al. 2021. Nat Commun. 1507:12. PubMed
  30. Amanat F, et al. 2021. Cell. 184:3936. PubMed
  31. Okurut S, et al. 2020. Infect Immun. 88:. PubMed
  32. Turner JS, et al. 2021. Nature. 596:109. PubMed
  33. Karim F, et al. 2021. Elife. 10:. PubMed
  34. Bhuiyan TR, et al. 2022. PLoS Negl Trop Dis. 16:e0010411. PubMed
  35. Isobe T, et al. 2022. Nat Commun. 13:4501. PubMed
  36. Turner JS, et al. 2020. Nature. 586:127. PubMed
  37. Albayrak E, et al. 2021. J Cell Physiol. 236:8122. PubMed
  38. Huang M, et al. 2021. BMC Infect Dis. 21:922. PubMed
  39. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  40. Chen PM, et al. 2022. Sci Adv. 8:eabo4271. PubMed
  41. Kfoury Y, et al. 2021. Cancer Cell. 39:1464. PubMed
  42. Kuloglu ZE, et al. 2022. Allergy. 77:2459. PubMed
  43. Albayrak E, et al. 2022. J Cell Biochem. 123:2009. PubMed
  44. He T, et al. 2023. Immun Inflamm Dis. 11:e759. PubMed
  45. Chen HY, et al. 2022. Elife. 11:. PubMed
  46. Parry H, et al. 2022. Cell Rep Med. 3:100739. PubMed
  47. Crees ZD, et al. 2023. Nat Med. 29:869. PubMed
RRID
AB_1279235 (BioLegend Cat. No. 303515)
AB_2072782 (BioLegend Cat. No. 303516)

Antigen Details

Structure
ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD
Distribution

T cells, B cells, NK, myeloid, plasma, and dendritic cells

Function
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, Dendritic cells, NK cells, Plasma cells, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151.
2. Lund F, et al. 1995. Immunol. Today 16:469.

Gene ID
952 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org
Go To Top Version: 2    Revision Date: 12/17/2021

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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