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- Clone
- 4G8C11 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACE-2, ACEH
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human ACE2 transfected SW480 cells (human colon adenocarcinoma cell line) were stained with purified anti-human ACE2 (clone S22015B) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by goat anti-mouse IgG PE.
Angiotensin-converting enzyme 2 (ACE2) is a type one transmembrane protein, which shares approximately 60% homology with ACE. The predicted human ACE2 protein sequence consists of 805 amino acids, including an N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE2 catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction. ACE2 has been shown to be a functional receptor for the spike glycoprotein of the human coronavirus, HCoV-NL63, and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2. Based on recent single-cell RNA sequencing database, high ACE2 RNA expression was identified in the lung, esophagus, kidney, intestine, bile duct, heart, testis, endothelial cells, and vascular smooth muscle cells.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
- Structure
- Type one transmemberance protein. Catalytic domain.
- Distribution
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Type II alveolar cells (AT2) of lung, esophagus upper and stratified epithelial cells, kidney proximal tubule cells, enterocytes in ileum and colon, cholangiocyte in bile duct, myocardial cells in heart, endothelium and vascular smooth muscle cells
- Function
- Catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction
- Cell Type
- Epithelial cells
- Biology Area
- Cell Adhesion, COVID-19
- Molecular Family
- Adhesion Molecules
- Antigen References
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- South AM, et al. 2020. Nat Rev Nephrol. 16:305-307.
- Hoffmann M, et al. 2020. Cell. 181:271-280.
- Sungnak W, et al. 2020. Nat Med. 26:681-687.
- Li W, et al. 2003. Nature. 426:450-4.
- Heurich A, et al. 2014. J Virol. 88:1293-307.
- Hamming I, et al. 2004. J Pathol. 203:631-7.
- Gene ID
- 59272 View all products for this Gene ID
- UniProt
- View information about ACE2 on UniProt.org
Related FAQs
Other Formats
View All ACE2 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human ACE2 | 4G8C11 | FC |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human ACE2
Human ACE2 transfected SW480 cells (human colon adenocarcino...
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