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- Clone
- B6 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell receptor V δ 2, TRDV2, TCRDV102S1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with CD3 Alexa Fluor® 488 and TCR Vδ2 (clone B6) APC/Fire™ 750 (top) or mouse IgG1, κ APC/Fire™ 750 isotype control (bottom). -
| Cat # | Size | Price | Save |
|---|---|---|---|
| 331419 | 25 tests | ¥32,340 | |
| 331420 | 100 tests | ¥78,760 |
The Vδ2 TCR is a variant of the TCR δ chain expressed on a subset of γ/δ T cells. Vγ9Vδ2 T lymphocytes, a major γ/δ T cell subset in humans, recognize phosphoantigens, certain tumor cells, and cells treated with aminobisphosphonates. This cell population displays cytolytic activity against various tumor cells. The γ/δ TCR is an heterodimeric TCR complex composed of covalently bound γ and δ chains involved in antigen recognition and the non-covalently associated monomorphic proteins CD3δ, γ, ε, and ζ chains.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm. - Excitation Laser
-
Red Laser (633 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Rojas RE, et al. 2005. J. Infect. Dis. 192:1806.
- Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
- Product Citations
- RRID
-
AB_2687325 (BioLegend Cat. No. 331419)
AB_2687326 (BioLegend Cat. No. 331420)
Antigen Details
- Structure
- Ig superfamily member, TCR γ/δ with CD3 forms the CD3/TCR complex
- Distribution
-
Expressed on majority of peripheral γ/δT cells
- Function
- Antigen recognition, T cell activation
- Ligand/Receptor
- Peptide bound to MHC
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
-
1. Scotet E, et al. 2005. Immunity 22:71.
2. Rincon-Orozco B, et al. 2005. J. Immunol. 175:2144. - Gene ID
- 6964 View all products for this Gene ID
- UniProt
- View information about TCR Vdelta2 on UniProt.org
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