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- Clone
- 162.1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD2 like receptor activating cytotoxic cells, CD319, CS1, 19A24, SLAMF7
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with CD3 FITC and CD319 (clone 162.1) APC (top) or mouse IgG2b, κ APC isotype control (bottom). -
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 331809 | 25 tests | 120€ | ||||
| 331810 | 100 tests | 261€ | ||||
CD319 is a single-pass type l transmembrane glycoprotein, expressed on NK cells, subsets of mature dendritic cells, activated B cells, and cytotoxic lymphocytes, but not in promyelocytic, B or T cell lines. Expression is highest in the spleen, lymph nodes, and peripheral blood leukocytes, and lowest in bone marrow. Additionally, it is expressed in the small intestine, stomach, appendix, lung, and trachea. CD319 is tyrosine phosphorylated in activated NK cells and is associated with 19 and 39 kD proteins. CD319 has homology with the CD2 family of receptors within the Ig superfamily. Some of the CD2 members stimulate cytotoxicity through the CD319 associated protein.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- CRACC-Human IgG1 fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Red Laser (633 nm)
- Application References
-
- Bouchon A, et al. 2001. J. Immunol. 167:551721.
- Tassi I and Colonna M. 2005. J. Immunol. 175:79968002.
- Veillette A. 2006. Immunol. Rev. 214:2234.
- Product Citations
- RRID
-
AB_2564332 (BioLegend Cat. No. 331809)
AB_2564333 (BioLegend Cat. No. 331810)
Antigen Details
- Structure
- Ig superfamily, 66 kD.
- Distribution
-
NK cells, subsets of mature dendritic cells, activated B cells, cytotoxic lymphocytes but not in promyelocytic, B or T cell lines.
- Function
- Regulates T cell and NK cell functions.
- Cell Type
- B cells, Dendritic cells, Lymphocytes, NK cells, Tregs
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Bouchon A, et al. 2001. J. Immunol. 167:551721.
2. Tassi I and Colonna M. 2005. J. Immunol. 175:79968002.
3. Veillette A. 2006. Immunol. Rev. 214:2234. - Gene ID
- 57823 View all products for this Gene ID
- UniProt
- View information about CD319 on UniProt.org
Related FAQs
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