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- Clone
- A21121I (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TRAIL-R2, KILLER, TRICK2, TNFRSF10B, Ly98, CD262
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes were stained with anti-human CD14 (clone HCD14) APC and anti-human CD262 (DR5, TRAIL-R2) (clone A21121I) PE (left) or mouse IgG2a, κ PE isotype control (right). -
Human monocytic cell line, U937, was stained with anti-human CD262 (DR5, TRAIL-R2) (clone A21121I) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 390705 | 25 tests | 104€ | ||||
| 390706 | 100 tests | 240€ | ||||
DR5, also known as TRAIL-R2, TRICK2, KILLER, and CD262, is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B). It binds the cytotoxic ligand, TRAIL, and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human TNFRSF10B
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone A21121I does not block the staining of reference clone DJR2-4 (7-8)
Recombinant protein completely blocks the staining of test clone A21121I.
Antigen Details
- Structure
- TNFR superfamily, 55 kD
- Distribution
-
Broadly expressed on normal and tumor cells
- Function
- Induces apoptosis
- Ligand/Receptor
- TRAIL
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
- MacFarlane M, et al. 1997. J Biol Chem. 272:25417-20.
- Walczak H, et al. 1997. EMBO J. 16:5386-97.
- Shigeno M, et al. 2003. Oncogene. 22:1653-62.
- LaVallee TM, et al. 2003. Cancer Res. 63:468-75.
- Nimmanapalli R, et al. 2001. Cancer Res. 61:759-63.
- Gene ID
- 8795 View all products for this Gene ID
- UniProt
- View information about CD262 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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