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- Clone
- TUGh4 (See other available formats)
- Regulatory Status
- RUO
- Workshop
- VI C-89
- Other Names
- Common γ chain, γc, IL-2 receptor γ subunit
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes stained with TUGh4 APC
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 338607 | 25 tests | 114€ | ||||
| 338608 | 100 tests | 266€ | ||||
CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common γ chain (γc), or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Red Laser (633 nm)
- Application References
-
- Itano M, et al. 1996. J. Exp. Med. 178:389
- Kondo M, et al. 1993. Science 262:1874
- Product Citations
- RRID
-
AB_2123585 (BioLegend Cat. No. 338607)
AB_2123584 (BioLegend Cat. No. 338608)
Antigen Details
- Structure
- Type I transmembrane glycoprotein, Ig superfamily 64-70 kD
- Distribution
-
T cells, B cells, NK, monocytes, granulocytes
- Ligand/Receptor
- Component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21
- Cell Type
- B cells, Granulocytes, Monocytes, NK cells, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Nakarai T, et al. 1994. J. Exp. Med. 180:241
3. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724
4. Habib T, et al. 2002. Biochemistry. 41:8725
5. Matthews DJ, et al. 1995. Blood 85:38 - Gene ID
- 3561 View all products for this Gene ID
- UniProt
- View information about CD132 on UniProt.org
Related Pages & Pathways
Pathways
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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