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Purified anti-human CD38 Antibody

Pricing & Availability
Clone
HIT2 (See other available formats)
Regulatory Status
RUO
Workshop
III 155
Other Names
T10, ADP-ribosyl cyclase
Isotype
Mouse IgG1, κ
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Product Citations
publications
HIT2_Purified_062507
Human peripheral blood lymphocytes stained with purified HIT2, followed by anti-mouse IgGs FITC
  • HIT2_Purified_062507
    Human peripheral blood lymphocytes stained with purified HIT2, followed by anti-mouse IgGs FITC
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303502 100 µg 48€
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6 and spatial biology (IBEX)10,11.

Application References
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373.
  3. Esser M, et al. 2001. J. Virol. 75:6173.
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044.
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107.
  6. van der Voort R, et al. 1997. J. Exp. Med. 185:2121. (IHC)
  7. Bende RJ, et al. 2003. Am. J. Pathol. 162:105.
  8. Lehner M, et al. 2008. J. Leukoc. Biol. 83:883. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  2. Olin A, et al. 2018. Cell. 174:1277. PubMed
  3. Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
  4. Han L, et al. 2019. Haematologica. 10.3324/haematol.2018.205534. PubMed
  5. Tornack J, et al. 2017. PLoS One. 12:e0169119. PubMed
  6. Gee MH, et al. 2018. Cell. 172:549. PubMed
  7. Meckiff BJ, et al. 2019. J Immunol. 203:1276. PubMed
  8. Eccles JD, et al. 2020. Cell Rep. 30:351. PubMed
  9. Li Z, et al. 2020. J Clin Lab Anal. 34:e23155. PubMed
  10. Zhou H, et al. 2017. Leukemia. 31:2065. PubMed
  11. Chng MHY, et al. 2020. Immunity. 51(6):1119-1135.e5.. PubMed
  12. Stras SF, et al. 2020. Developmental Cell. 51(3):357-373.e5.. PubMed
  13. Galbraith MD, et al. 2021. eLife. 10:00. PubMed
  14. Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
  15. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  16. Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed
  17. Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed
  18. Henrick BM, et al. 2021. Cell. . PubMed
  19. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  20. Sullivan KD, et al. 2021. Cell Reports. 36(7):109527. PubMed
  21. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  22. Rouers A, et al. 2021. Cell Rep Med. 2:100278. PubMed
  23. Chiou SH, et al. 2021. Immunity. 54:586. PubMed
  24. Chakhtoura M, et al. 2021. PLoS Pathog. 17:e1009732. PubMed
  25. Roukens AHE, et al. 2022. Nat Immunol. 23:23. PubMed
  26. Stensland ZC, et al. 2022. iScience. 25:103626. PubMed
  27. NULL, et al. 2022. Cell. 185:916. PubMed
  28. Newell KL, et al. 2021. PLoS One. 16:e0244855. PubMed
  29. Crawford LB, et al. 2021. J Virol. 95:. PubMed
  30. Syrimi E, et al. 2021. iScience. 24:103215. PubMed
  31. O'Boyle KC, et al. 2020. Methods Mol Biol. 2111:1. PubMed
  32. Baum N, et al. 2020. Cancers (Basel). 13:. PubMed
  33. Vivanco Gonzalez N, et al. 2022. STAR Protoc. 3:101280. PubMed
  34. Baskar R, et al. 2022. Cell Rep Methods. 2:. PubMed
  35. Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed
  36. Alpert A, et al. 2022. Cell Syst. 13:71. PubMed
  37. McCarthy EE, et al. 2022. Cell Rep. 39:110815. PubMed
  38. Feyaerts D, et al. 2022. Cell Rep Med. 3:100680. PubMed
RRID
AB_314354 (BioLegend Cat. No. 303502)

Antigen Details

Structure
ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD
Distribution

T cells, B cells, NK, myeloid, plasma, and dendritic cells

Function
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, Dendritic cells, NK cells, Plasma cells, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151.
2. Lund F, et al. 1995. Immunol. Today 16:469.

Gene ID
952 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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