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PE anti-human CD56 (NCAM) Antibody

Pricing & Availability
Clone
5.1H11 (See other available formats)
Regulatory Status
RUO
Other Names
Leu-19, NKH1, NCAM-1
Isotype
Mouse IgG1, κ
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Product Citations
publications
5.1H11_PE_CD56_Antibody_FC_062014.jpg
Human peripheral blood lymphocytes were stained with CD56 (clone 5.1H11) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • 5.1H11_PE_CD56_Antibody_FC_062014.jpg
    Human peripheral blood lymphocytes were stained with CD56 (clone 5.1H11) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
Cat # Size Price Quantity Check Availability Save
362507 25 tests 94€
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362524 100 µg 205€
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362508 100 tests 210€
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Description

CD56 is a single transmembrane glycoprotein also known as NCAM (neural cell adhesion molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK and NKT cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparan sulfate.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human myotube cells
Formulation
µg size: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
test sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
µg sizes: 0.2 mg/mL
test sizes: lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the µg size, the suggested use of this reagent is ≤0.4 µg per million cells in 100 µl volume. For flow cytometric staining using test sizes, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References
  1. Walsh FS, et al. 1981. Nature 289:60. (FC)
  2. Pavlath GK, et al. 1986. J. Cell Biol. 102:124. (FC)
  3. Pavlath GK, et al. 1989. Nature 337:570. (FC)
  4. Pulido R, et al. 1988. J. Immunol. 140:3851. (FC)
Product Citations
  1. Segal JM, et al. 2019. Nat Commun. 10:3350. PubMed
  2. Liu B, et al. 2019. Mol Med Rep. 20:2823. PubMed
  3. Brighton PJ et al. 2017. eLife. 6 pii: e31274. PubMed
  4. Lavaert M, et al. 2020. Immunity. 52(6):1088-1104. PubMed
  5. Shaffer TM, et al. 2020. J Nucl Med. 1348:61. PubMed
  6. Tomita T, et al. 2021. Nat Commun. 12:3655. PubMed
  7. Zheng G, et al. 2021. Signal Transduct Target Ther. 6:236. PubMed
  8. Chen P, et al. 2021. Front Immunol. 12:689019. PubMed
  9. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  10. Scherer SD, et al. 2021. Breast Cancer Res. 23:100. PubMed
  11. Ding L, et al. 2021. Cancers (Basel). 13:. PubMed
  12. Rodriguez A, et al. 2021. Cell Stem Cell. 28:33. PubMed
  13. Wang F, et al. 2021. Genomics Proteomics Bioinformatics. 19:208. PubMed
  14. Kim MY, et al. 2021. JCI Insight. 6:. PubMed
  15. Chakraborty S, et al. 2022. Sci Transl Med. . PubMed
  16. Vanoni G, et al. 2022. Bio Protoc. 218:. PubMed
  17. Leibel SL, et al. 2022. iScience. 25:103797. PubMed
  18. Wu X, et al. 2020. Cancers (Basel). 12:. PubMed
  19. Wu X, et al. 2021. Front Immunol. 12:731767. PubMed
  20. Janssen JJE, et al. 2022. Am J Physiol Endocrinol Metab. 322:E141. PubMed
  21. Gupta R, et al. 2022. Front Immunol. 13:886442. PubMed
  22. Bayley JP, et al. 2022. PLoS One. 17:e0274478. PubMed
  23. Liu J, et al. 2022. iScience. 25:105509. PubMed
  24. Pan R, et al. 2022. Cell. 185:1521. PubMed
  25. Wu X, et al. 2023. iScience. 26:106559. PubMed
RRID
AB_2563924 (BioLegend Cat. No. 362507)
AB_2564161 (BioLegend Cat. No. 362524)
AB_2563925 (BioLegend Cat. No. 362508)

Antigen Details

Structure
Ig superfamily, single transmembrane or GPI-anchored glycoprotein
Distribution

NK cells, T subset, neural tissue, some LGL and myeloid leukemias

Function
Adhesion
Ligand/Receptor
Heparan sulfate
Antigen References

1. Lanier L, et al. 1991. J. Immunol. 146:4421
2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71
3. Cremer H, et al. 1994. Nature 367:455.

Gene ID
4684 View all products for this Gene ID
UniProt
View information about CD56 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 07-08-2014

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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